Release of noradrenaline and ATP by electrical stimulation and nicotine in guinea-pig vas deferens

1991 ◽  
Vol 344 (4) ◽  
pp. 419-429 ◽  
Author(s):  
Ivar von Kügelgen ◽  
Klaus Starke
Keyword(s):  
Electrical Stimulation ◽  
Guinea Pig ◽  
Vas Deferens ◽  
Release Of Noradrenaline

Some Pharmacological Effects of Prodolic Acid, a New Anti-inflammatory Compound, Indicative of Inhibition of Prostaglandin Synthesis

1975 ◽  
Vol 53 (1) ◽  
pp. 186-189 ◽  
Author(s):  
R. Greenberg
Keyword(s):  
Electrical Stimulation ◽  
Guinea Pig ◽  
Portal Vein ◽  
Vas Deferens ◽  
Prostaglandin Synthesis ◽  
Pharmacological Effects ◽  
Prostaglandin Biosynthesis ◽  
Inhibition Of Prostaglandin Synthesis ◽  
Anti Inflammatory ◽  
Rabbit Vas Deferens

Prodolic acid, a new non-steroidal anti-inflammatory compound, inhibited bradykinin-induced bronchoconstriction but did not affect histamine-induced bronchoconstriction in the guinea pig. Prodolic acid potentiated the responses of the isolated rabbit vas deferens and portal vein to electrical stimulation without altering the response to noradrenaline. The potentiating effects of prodolic acid on the vas deferens were reversible but the potentiating effects in the portal vein were frequency-dependent. It is concluded that these effects of prodolic acid are probably related to its ability to inhibit prostaglandin biosynthesis.

Ultrastructure, calcium accumulation, and contractile response in smooth muscle

1976 ◽  
Vol 230 (5) ◽  
pp. 1217-1224 ◽  
Author(s):  
LJ McGuffee ◽  
RM Bagby
Keyword(s):  
Smooth Muscle ◽  
Electrical Stimulation ◽  
Guinea Pig ◽  
Vas Deferens ◽  
Contractile Response ◽  
Taenia Coli ◽  
Tetraacetic Acid ◽  
Cytoplasmic Matrix ◽  
Internal Storage ◽  
Storage Structures

After removing extracellular Ca2+ with [ethylene bis(oxyethylenenitrilo)]tetraacetic acid, we found that the guinea pig vas deferens (VD) was mechanically responsive to electrical stimulation for a significantly greater length of time than was guinea pig taenia coli (TC). An obvious explanation for these findings is that the VD has more intracellular calcium available for contraction than does the TC. To determine if this explanation is plausible, the volume of internal storage structures within the two muscles was compared. It was found that the volumes of potential sequestering structures in the VD and TC are not significantly different. Next, the affinities of the storage structures for calcium were compared. The VD was found to accumulate approximately twice as much 45Ca as did the TC, as determined by 45Ca autoradiography. Calcium-45 was present to a greater extent in association with surface vesicles, sarcoplasmic reticulum (SR), and mitochondria than in the unassociated state within the cytoplasmic matrix. Based on the results of these experiments, we suggest that the VD and the TC of the guinea pig differ in the affinity of their storage sites for calcium.

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