Relationship of inhibition of prostaglandin synthesis in platelets to anti-aggregatory and anti-inflammatory activity of some benzoic acid derivatives

1981 ◽  
Vol 11 (3) ◽  
pp. 281-286 ◽  
Author(s):  
I. Cerskus ◽  
R. B. Philp
Keyword(s):  
Benzoic Acid ◽  
Prostaglandin Synthesis ◽  
Inflammatory Activity ◽  
Benzoic Acid Derivatives ◽  
Inhibition Of Prostaglandin Synthesis ◽  
Anti Inflammatory ◽  
Relationship Of

scholarly journals The Beneficial Biological Properties of Salicylic Acid

2015 ◽  
Vol 32 (4) ◽  
pp. 259-265 ◽  
Author(s):  
Pavle Randjelović ◽  
Slavimir Veljković ◽  
Nenad Stojiljković ◽  
Dušan Sokolović ◽  
Ivan Ilić ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Well Being ◽  
Biological Properties ◽  
Vital Role ◽  
Prostaglandin Synthesis ◽  
Beneficial Effects ◽  
Inhibition Of Prostaglandin Synthesis ◽  
Anti Inflammatory ◽  
Antiinflammatory Effects

Summary Salicylic acid is a phytochemical with beneficial effects on human well-being. Salicylic acid is a phenolic compound and is present in various plants where it has a vital role in protection against pathogenic agents. Natural sources include fruits, vegetables and spices. The most famous and defined effect of salicylic acid is prostaglandin synthesis inhibition. Salicylic acid has antiinflammatory effects through suppression of transcription of genes for cyclooxygenase. Most of the pharmacological properties of salicylic acid can be contributed to the inhibition of prostaglandin synthesis. Also, it was discovered that salicylic acid has other in vivo cyclooxygenase-independent pathways. Since salicylic acid does not inhibit cyclooxygenase considerably, the anti-inflammatory effect is not a consequence of direct inhibition of cyclooxygenase activity. Because of its fundamental role, it was suggested that inhibition of nuclear factor kappa B by salicylic acid is one of the key anti-inflammatory mechanisms of action for salicylates. One of the most studied properties of salicylic acid is its antioxidative activity. Salicylic acid is a confirmed inhibitor of oxidative stress. Salicylic acid is capable of binding iron. This fact is significant for antioxidative effect of salicylic acid because iron has an important function in the course of lipid peroxidation.

scholarly journals IN VITRO ANTI-INFLAMMATORY ACTIVITY OF THE COMPONENTS OF AMOMUM TSAO-KO IN MURINE MACROPHAGE RAW 264.7 CELLS

2018 ◽  
Vol 15 (2) ◽  
pp. 26
Author(s):  
Chun Whan Choi ◽  
Ju Young Shin ◽  
Changon Seo ◽  
Seong Su Hong ◽  
Eun-Kyung Ahn ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Benzoic Acid ◽  
Inflammatory Activity ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Dependent Manner ◽  
Murine Macrophage ◽  
Etoh Extract ◽  
Anti Inflammatory

Background: Plants still remain the prime source of drugs for the treatment of inflammation and can provide leads for the development of novel anti-inflammatory agents. Material and methods: An in vitro bioassay guide revealed that the 80% ethanol (EtOH) extract of the whole plant, Amomum tsao-ko (Zingiberaceae), displayed anti-inflammatory activity after assessing its effects on murine macrophage RAW 264.7 cells. Result: Phytochemical study of the 80% EtOH extract of Amomum tsao-ko led to the isolation of eight compounds: 4-hydroxy-3-methoxy-benzoic acid (1), meso-hannokinol (2), (+)-hannokinol (3), coumaric acid (4), 4-hydroxy-benzoic acid (5), (+)-epicatechin (6), (-)-catechin (7), and myrciaphenone A (8). The results indicated that two of the isolated components, (+)-epicatechin (6) and (-)-catechin (7), inhibited the production of nitric oxide (NO) significantly in lipopolysaccharide treated RAW 264.7 cells. Conclusion: LPS-induced interleukin tumor necrosis factor-alpha (TNF-), IL-1β and IL-10 production was also decreased in a dose-dependent manner. In addition, western blot analysis revealed that (+)-epicatechin (6) and (-)-catechin (7) reduced the expression of inducible nitric oxide synthase and inhibited nuclear localization of nuclear factor kappa-B (NF-κB).

Relationship of chemical structure and anti-inflammatory activity of dihydrocorynantheol and its analogues

2013 ◽  
Vol 65 (5) ◽  
pp. 1263-1271
Author(s):  
Patrícia Pozzatti ◽  
Gustavo O. dos Reis ◽  
Danielle F. Pereira ◽  
Heros Horst ◽  
Leandro Espindola ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Relationship Of
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