The responses of rat and guinea pig vas deferens to cocaine

1969 ◽  
Vol 47 (5) ◽  
pp. 469-476 ◽  
Author(s):  
M. M. Vohra
Keyword(s):  
Guinea Pig ◽  
Adrenergic Receptors ◽  
Vas Deferens ◽  
Rat Vas Deferens ◽  
Motor Responses ◽  
Transmural Stimulation ◽  
Alpha Adrenergic Receptors ◽  
Sympathomimetic Amine ◽  
Repeated Doses ◽  
Stimulation Of

Cocaine caused contractions and potentiation of motor responses to transmural stimulation of vas deferens of the rat but not of the guinea pig. Tachyphylaxis was not observed after repeated doses of cocaine to vasa deferentia from both normal and reserpine-treated rats. Pretreatment with reserpine reduced significantly (p < 0.05) the responses to cocaine but abolished completely the responses to tyramine. No catecholamines could be detected spectrophotofluorometrically in reserpine-treated preparations. Contractions following the application of cocaine to vasa deferentia from both normal and reserpine-treated rats were completely abolished by phenoxybenzamine, phentolamine, and tolazoline. Cocaine failed to protect alpha-adrenergic receptors against phenoxybenzamine blockade in reserpine-treated preparations; however, cocaine could still evoke contractions of reserpine-treated preparations protected with noradrenaline against phenoxybenzamine blockade. The evidence presented indicates that cocaine acts as a mixed sympathomimetic on the rat vas deferens preparation. The possibility that cocaine is an indirect-acting sympathomimetic amine could not be ruled out in the present study.

scholarly journals Role of .ALPHA.-adrenergic receptors in denervation supersensitivity of rat vas deferens.

1981 ◽  
Vol 31 (3) ◽  
pp. 383-390 ◽  
Author(s):  
Fumiaki HATA ◽  
Kunio TAKEYASU ◽  
Yoshio MORIKAWA ◽  
Ron-Tsan LAI ◽  
Hajime ISHIDA ◽  
...  
Keyword(s):  
Adrenergic Receptors ◽  
Vas Deferens ◽  
Rat Vas Deferens ◽  
Alpha Adrenergic Receptors ◽  
Denervation Supersensitivity

Reorganization of the innervation of the vas deferens after sympathetic decentralization

1996 ◽  
Vol 271 (6) ◽  
pp. R1481-R1488
Author(s):  
K. Kihara ◽  
H. Kakizaki ◽  
W. C. de Groat
Keyword(s):  
Electrical Stimulation ◽  
Vas Deferens ◽  
Ganglion Cells ◽  
Rat Vas Deferens ◽  
Pelvic Nerve ◽  
Hypogastric Nerve ◽  
Normal Side ◽  
Efferent Pathways ◽  
Stimulation Of

Reorganization of autonomic efferent pathways to the rat vas deferens was noted after chronic (30 days) sympathetic decentralization produced by hypogastric nerve (HGN) transection. In normal rats, electrical stimulation of the HGN elicited an increase in vasal pressure (VP) bilaterally, whereas pelvic nerve (PN) stimulation did not alter VP. However, after unilateral HGN transection, stimulation of the PN on the transected side but not on the normal side increased VP. The decentralized vas exhibited larger VP responses to stimulation of the contralateral HGN in comparison with the normal vas. After bilateral HGN transection, PN-induced VP responses were elicited at lower stimulus intensities than in rats with unilateral transections. PN-induced VP responses were blocked by hexamethonium and prazosin but were not altered by atropine. Distension of the vas lumen occurred after decentralization. PN-induced VP responses were not detectable in extremely distended vas. These data indicate that, after degeneration of sympathetic preganglionic axons, decentralized adrenergic ganglion cells are reinnervated by parasympathetic or sympathetic preganglionic pathways and that the reinnervation influences vasal function.

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