Nature of the N6 region of the adenosine receptor in guinea-pig ileum and rat vas deferens

1986 ◽  
Vol 333 (3) ◽  
pp. 313-322 ◽  
Author(s):  
David M. Paton ◽  
R. A. Olsson ◽  
Robert T. Thompson
Keyword(s):  
Guinea Pig ◽  
Adenosine Receptor ◽  
Vas Deferens ◽  
Rat Vas Deferens ◽  
Guinea Pig Ileum

Opiatelike actions of eseroline, an eserine derivative

1981 ◽  
Vol 59 (3) ◽  
pp. 307-310 ◽  
Author(s):  
K. Jhamandas ◽  
J. Elliott ◽  
M. Sutak
Keyword(s):  
Guinea Pig ◽  
Myenteric Plexus ◽  
Vas Deferens ◽  
Longitudinal Muscle ◽  
Rat Vas Deferens ◽  
Anticholinesterase Activity ◽  
Muscle Preparation ◽  
Guinea Pig Ileum ◽  
Anesthetized Rats ◽  
Release Of Acetylcholine

Eseroline, an eserine derivative without anticholinesterase activity, was tested in several systems for opiatelike activity. Eseroline depressed the twitch of the field-stimulated guinea pig ileum myenteric plexus longitudinal muscle preparation but failed to depress the twitch of the rat vas deferens. Intraperitoneal injections of eseroline in rats induced naloxone-antagonizable analgesia and catalepsy. Eseroline failed to influence the release of acetylcholine from the cortex of anesthetized rats. These observations have implications for studies in which eserine is used as a pharmacological tool.

scholarly journals A pharmacological study with substance K and substance P in the guinea-pig ileum and in the rat vas deferens

1986 ◽  
Vol 40 ◽  
pp. 246
Author(s):  
Hiro-o Kamiya ◽  
Yukio Takano ◽  
Yasuyuki Hatae ◽  
Akira Nagashima ◽  
Yasuyuki Shimohigashi ◽  
...  
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Vas Deferens ◽  
Pharmacological Study ◽  
Rat Vas Deferens ◽  
Guinea Pig Ileum ◽  
Substance K
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