scholarly journals Role of .ALPHA.-adrenergic receptors in denervation supersensitivity of rat vas deferens.

1981 ◽  
Vol 31 (3) ◽  
pp. 383-390 ◽  
Author(s):  
Fumiaki HATA ◽  
Kunio TAKEYASU ◽  
Yoshio MORIKAWA ◽  
Ron-Tsan LAI ◽  
Hajime ISHIDA ◽  
...  
1981 ◽  
Vol 31 (3) ◽  
pp. 383-390
Author(s):  
Fumiaki HATA ◽  
Kunio TAKEYASU ◽  
Yoshio MORIKAWA ◽  
Ron-Tsan LAI ◽  
Hajime ISHIDA ◽  
...  

1980 ◽  
Vol 30 ◽  
pp. 125
Author(s):  
Fumiaki Hata ◽  
Kunio Takeyasu ◽  
Ron-Tsan Lai ◽  
Hajime Ishida ◽  
Hiroshi Yoshida

1969 ◽  
Vol 47 (5) ◽  
pp. 469-476 ◽  
Author(s):  
M. M. Vohra

Cocaine caused contractions and potentiation of motor responses to transmural stimulation of vas deferens of the rat but not of the guinea pig. Tachyphylaxis was not observed after repeated doses of cocaine to vasa deferentia from both normal and reserpine-treated rats. Pretreatment with reserpine reduced significantly (p < 0.05) the responses to cocaine but abolished completely the responses to tyramine. No catecholamines could be detected spectrophotofluorometrically in reserpine-treated preparations. Contractions following the application of cocaine to vasa deferentia from both normal and reserpine-treated rats were completely abolished by phenoxybenzamine, phentolamine, and tolazoline. Cocaine failed to protect alpha-adrenergic receptors against phenoxybenzamine blockade in reserpine-treated preparations; however, cocaine could still evoke contractions of reserpine-treated preparations protected with noradrenaline against phenoxybenzamine blockade. The evidence presented indicates that cocaine acts as a mixed sympathomimetic on the rat vas deferens preparation. The possibility that cocaine is an indirect-acting sympathomimetic amine could not be ruled out in the present study.


1980 ◽  
Vol 48 (2) ◽  
pp. 329-336 ◽  
Author(s):  
W. H. Beinfield ◽  
J. Seifter

Contraction, relaxation, and longitudinal tension were recorded by isometric strain gauge arches attached to cervical tracheal muscle (CTM) in 60 spontaneously breathing dogs anesthetized with pentobarbital. Intravenous norepinephrine (NE) (3 X 10(-9), 6 X 10(-9), 1.2 X 10(-8), and 2.4 x 10(-8) mol/kg) increased spontaneous mechanical activities (SMA) and caused dose related contraction of CTM in all dogs even though there was no pretreatment with beta-blockers. These activities were first potentiated by propranolol and then prevented by phentolamine. NE briefly decreased SMA and induced CTM relaxation prior to the onset of contraction in one-third of dogs. Propranolol prevented this initial relaxation. CTM responses induced by NE were 1) not significantly altered by atropine, tripelennamine, bilateral vagotomy, curarization, and complete tracheal transection below transducer sites; 2) unrelated to passive constriction of cervical trachea associated with airway elongation; and 3) independent of reflexes initiated by elevations of systemic arterial pressure. The moles per kilogram doses of acetylcholine were found to exceed those of NE when their intravenous administration caused equal CTM contractions in the same dog. These findings are consistent with the existence of alpha-adrenergic receptors in CTM.


2000 ◽  
Vol 12 (S1) ◽  
pp. S48-S63 ◽  
Author(s):  
A Traish ◽  
NN Kim ◽  
RB Moreland ◽  
I Goldstein

2008 ◽  
Vol 586 (20) ◽  
pp. 4843-4857 ◽  
Author(s):  
Ye Chun Ruan ◽  
Zhe Wang ◽  
Jian Yang Du ◽  
Wu Lin Zuo ◽  
Jing Hui Guo ◽  
...  

1994 ◽  
Vol 350 (5) ◽  
pp. 491-498 ◽  
Author(s):  
Anna Kordelia Kurz ◽  
Ralph Bültmann ◽  
Bernd Driessen ◽  
Ivar von Kügelgen ◽  
Klaus Starke

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