THE EFFECT OF COLD EXPOSURE ON PLASMA AND LIVER CHOLESTEROL LEVELS IN RATS FED VARIOUS DIETS

1964 ◽  
Vol 42 (6) ◽  
pp. 779-785
Author(s):  
J. D. Wood
Keyword(s):  
Cold Exposure ◽  
Small Difference ◽  
Cholesterol Concentration ◽  
Liver Cholesterol ◽  
Deficient Diet ◽  
Cholesterol Levels ◽  
Male Wistar Rats ◽  
Fatty Livers ◽  
Tissue Cholesterol ◽  
Environmental Temperatures

Plasma and liver cholesterol levels were compared in male Wistar rats kept at environmental temperatures of 2 °C and 23 °C on various dietary regimens. Cold exposure had little or no effect on the tissue cholesterol levels provided the diet contained appreciable amounts of choline and inositol, the only statistically significant change observed being a small difference in the liver cholesterol concentration in rats maintained on a cholesterol-free diet. A choline- and inositol-deficient diet produced a hypocholesterolemic effect in rats at 23 °C but this effect was counteracted by exposing the rats to a cold environment. The possible significance of this observation with regard to the biochemical defect in "choline deficient" fatty livers is discussed.

PYRIDOXINE DEFICIENCY AND CHOLESTEROGENESIS IN THE CHICK

1964 ◽  
Vol 42 (8) ◽  
pp. 1161-1168 ◽  
Author(s):  
P. J. Lupien ◽  
B. B. Migicovsky
Keyword(s):  
Serum Cholesterol ◽  
Elevated Serum ◽  
Normal Serum ◽  
Liver Cholesterol ◽  
Acetate Incorporation ◽  
Deficient Diet ◽  
Pyridoxine Deficiency ◽  
Cholesterol Levels ◽  
Normal States ◽  
Elevated Serum Cholesterol

Physiological disturbances common to B6 avitaminosis were clearly manifested when 3-day-old chicks were fed a pyridoxine-deficient diet for 8 days. Body and liver weights were depressed but were restored to quasi-normal states after 4 days of pyridoxine supplementation (3 mg/lb diet). The elevated serum cholesterol levels observed were the result of a failure of this parameter to fall at the rate characteristic of a well-fed bird and not to a specific elevation of the serum cholesterol above the starting conditions. Liver cholesterol levels were unaffected by the hypovitaminosis. Pyridoxine supplementation rapidly re-established normal serum cholesterol levels.The significant depression of C14-acetate incorporation into liver and serum cholesterol of 7-day-old pyridoxine-deficient chicks was maintained for the next 8 days. Mevalonate-2-C14 incorporation into liver cholesterol was not significantly depressed by the hypovitaminosis at any time during the study. Unlike the controls, mevalonate-2-C14 incorporation into serum cholesterol was significantly lowered in the 11-day-old pyridoxine-deficient chicks, but not at any other time during the study.The significance of these findings and the possible relationship between these factors are discussed.

THE LIPOTROPIC ACTION OF COLD: 2. THE INFLUENCE OF COLD AND CHOLINE DEFICIENCY ON SERUM LIPIDS OF RATS AT DIFFERENT INTAKES OF DIETARY METHIONINE

1965 ◽  
Vol 43 (3) ◽  
pp. 451-456 ◽  
Author(s):  
M. W. Radomski ◽  
J. D. Wood
Keyword(s):  
Cold Exposure ◽  
Serum Lipids ◽  
Marked Decrease ◽  
Total Serum ◽  
Dietary Intakes ◽  
Total Lipids ◽  
Choline Deficiency ◽  
Lipid Levels ◽  
Cholesterol Levels ◽  
Fatty Livers

The effect of exposure of rats to cold for a 10-day period on the concentration of serum lipids in control and choline-deficient animals was studied at four dietary intakes of methionine. Changes in total lipids, total and free cholesterol, phospholipid, and triglyceride levels were measured.In control (choline-fed) animals, phospholipid, cholesterol, and the ratio of free:ester cholesterol levels were not altered by cold exposure, but a marked decrease (25–30%, P < 0.01) in the levels of total serum lipids occurred. This was a result of a 45–70% decrease in triglyceride levels. The concentration of the triglyceride-rich low-density lipoproteins (Sf 10–400) in the serum fell in the cold-exposed animals as indicated by lowered triglyceride:cholesterol ratios.Although cold exposure prevented fatty livers in choline-deficient rats at high methionine intakes, it did not prevent the characteristic decrease in serum lipids found in choline deficiency at any of the methionine intakes studied. Decreases in total lipids (20–40%), triglyceride (10–50%), cholesterol (15–40%), and phospholipids (15–40%) were found. It was concluded that the ability of cold exposure to overcome choline deficiency is limited, apparently, to the fatty liver syndrome and has no effect on the decreased serum lipid levels.

scholarly journals Alteration of regression of cholesterol accumulation in rats by dietary pectin

1984 ◽  
Vol 51 (3) ◽  
pp. 339-345 ◽  
Author(s):  
James N. Thomas ◽  
Michael J. Kelley ◽  
Jon A. Story
Keyword(s):  
Bile Acid ◽  
Chenodeoxycholic Acid ◽  
Basal Diet ◽  
Liver Cholesterol ◽  
Acid Excretion ◽  
Bile Acid Excretion ◽  
Cholesterol Levels ◽  
Lower Serum Cholesterol ◽  
Male Wistar Rats ◽  
Steroid Excretion

1. Male, Wistar rats (50–74 g) were given a semi-purified diet containing cholesterol (10 g/kg diet) for 4 weeks, groups of control and experimental animals killed, and the remainder of the cholesterol-fed animals given either a semi-purified cholesterol-free diet without a fibre source or a similar diet with pectin (50 g/kg diet) for 8 weeks. Animals were killed at 2-week intervals and serum and liver cholesterol and triglycerides, faecal neutral steroids and acidic steroids measured.2. Animals given pectin had significantly lower serum cholesterol levels than animals given the basal diet after 4 and 6 weeks.3. Both experimental groups efficiently decreased their liver cholesterol levels during regression.4. Bile acid excretion was elevated in both groups, especially in rats receiving pectin, but neutral steroid excretion was unchanged.5. The increase in bile acid excretion was primarily in the form of chenodeoxycholic acid and its metabolites.6. This increased bile acid excretion is postulated to result from stimulation of the normal mechanism for increased steroid excretion in the rat, i.e. a change in the value of cholic: chenodeoxycholic acid or from a mechanism not yet elucidated.

Dietary Calcium Supplementation Suppresses Bone Formation in Magnesium-Deficient Rats

2006 ◽  
Vol 76 (3) ◽  
pp. 111-116 ◽  
Author(s):  
Hiroshi Matsuzaki ◽  
Misao Miwa
Keyword(s):  
Bone Formation ◽  
Calcium Supplementation ◽  
Control Diet ◽  
Formation Rate ◽  
Dietary Calcium ◽  
Mineral Apposition Rate ◽  
Control Group ◽  
Deficient Diet ◽  
Bone Formation Rate ◽  
Male Wistar Rats

The purpose of this study was to clarify the effects of dietary calcium (Ca) supplementation on bone metabolism of magnesium (Mg)-deficient rats. Male Wistar rats were randomized by weight into three groups, and fed a control diet (control group), a Mg-deficient diet (Mg- group) or a Mg-deficient diet having twice the control Ca concentrations (Mg-2Ca group) for 14 days. Trabecular bone volume was significantly lower in the Mg - and Mg-2Ca groups than in the control group. Trabecular number was also significantly lower in the Mg - and Mg-2Ca groups than in the control group. Mineralizing bone surface, mineral apposition rate (MAR), and surface referent bone formation rate (BFR/BS) were significantly lower in the Mg - and Mg-2Ca groups than in the control group. Furthermore, MAR and BFR/BS were significantly lower in the Mg-2Ca group than in the Mg - group. These results suggest that dietary Ca supplementation suppresses bone formation in Mg-deficient rats.

Dietary carbohydrate and tissue cholesterol concentration in young rats

1970 ◽  
Vol 26 (1) ◽  
pp. 57-58 ◽  
Author(s):  
R. A. Ahrens ◽  
T. V. Besser ◽  
E. M. Blyler ◽  
J. M. Daniel ◽  
J. W. Smith
Keyword(s):  
Cholesterol Concentration ◽  
Dietary Carbohydrate ◽  
Young Rats ◽  
Tissue Cholesterol

Effect of Feeding Probioticated Functional Food Mixture on Serum Cholesterol Levels in Albino Rats

2016 ◽  
Vol 53 (3) ◽  
pp. 321
Author(s):  
Shilpa Huchchannanavar ◽  
D. Vijayalakshmi ◽  
Y. B. Rajeshwari ◽  
Suvarna Chavannavar ◽  
Usha Ravindra
Keyword(s):  
Serum Cholesterol ◽  
Normal Growth ◽  
Good Health ◽  
Good Effect ◽  
Albino Rats ◽  
Cholesterol Levels ◽  
Therapeutic Value ◽  
Male Wistar Rats ◽  
Effect Of Feeding ◽  
Food Mixture

Probiotics are dietary supplements containing potentially beneficial bacteria or yeasts. These probiotics promote good health and have therapeutic value. In this regard a study has been conducted to find the effect of probioticated millet mix on cholesterol levels in albino rats. Forty eight male Wistar rats were divided into six groups, all groups showed normal growth. Normal levels of serum hematological and serum values were observed where as Composite Mix Single Probiotic (CMSP) diet showed better results. Reduction in serum cholesterol, triglycerides, VLDL, LDL and improvement in the HDL levels were observed over a period of 45 days in experimental animals. CMSP was found to have good effect when compared to Composite Mix with Mixed Probiotic (CMMP). Hypocholesterolemic effect was observed in rats fed with CMSP diet.

THE RELATION OF DIETARY PROTEIN LEVEL TO LIVER ENZYME ACTIVITIES IN COLD-EXPOSED RATS

1963 ◽  
Vol 41 (1) ◽  
pp. 1871-1877
Author(s):  
John R. Beaton
Keyword(s):  
Cold Exposure ◽  
Dietary Protein ◽  
Protein Level ◽  
Liver Enzymes ◽  
Albino Rats ◽  
Protein Levels ◽  
Dietary Protein Level ◽  
Phosphate Activated Glutaminase ◽  
Relationship Of ◽  
Environmental Temperatures

Male, albino rats were fed diets containing 5%, 20%, and 40% casein by weight for 7 days at environmental temperatures of 22 °C and 2–3 °C. In one experiment, food was provided ad libitum; in a second experiment, all groups were provided with equal amounts of food. At 22 °C, the activities in liver of alanine-glutamic transaminase, phosphate-activated glutaminase, and arginase increased with increasing dietary protein level. At 2–3 °C, activities of the last two enzymes increased with increasing dietary protein level from 5% to 20% but not from 20% to 40% whereas transaminase activities increased throughout the dietary protein range 5% to 40%. No relationship of glucose-6-phosphatase activity to dietary protein level was evident at either environmental temperature. Cold exposure per se increased the activities of alanine-glutamic transaminase and glucose-6-phosphatase in all dietary protein groups but increased the activities of arginase and phosphate-activated glutaminase only in rats fed the 5% and 20% protein diets. It is postulated that increased activities of these liver enzymes during cold exposure result from augmented catabolism of substrates to meet increased energy requirements. As previously observed with respect to other metabolic alterations, it is apparent that cold exposure modifies the response of liver enzymes to changing dietary protein levels.

Sign in / Sign up

Export Citation Format

Share Document