Efficient addition of cerium(III) enolate of ethyl acetate to ketones: application to the synthesis of β-ethoxycarbonylmethyl α, β-unsaturated ketones

1991 ◽  
Vol 69 (12) ◽  
pp. 2008-2013 ◽  
Author(s):  
Hsing-Jang Liu ◽  
Bing-Yan Zhu
Keyword(s):  
Ethyl Acetate ◽  
Key Words ◽  
Unsaturated Ketones ◽  
Efficient Route ◽  
Ester Enolate

The cerium(III) enolate derived from ethyl acetate was shown to undergo facile addition with ketones. With conjugated enones, 1,2-addition products were formed exclusively. Oxidative 1,3-oxygen transportation of these products provides an efficient route to synthetically useful β-ethoxycarbonylmethyl α,β-unsaturated ketones. Key words: cerium(III) ester enolate, addition, ketones.

scholarly journals Toxicity of Thevetia peruviana (Pers) Schum. Extract to Adults of Callosobruchus maculatus F. (Coleoptera: Bruchidae)

1970 ◽  
pp. 105-109 ◽  
Author(s):  
JU Mollah ◽  
W Islam
Keyword(s):  
Ethyl Acetate ◽  
Key Words ◽  
Organic Solvents ◽  
Callosobruchus Maculatus ◽  
Root Extract ◽  
Thevetia Peruviana

Leaf, stem and roots of Thevetia peruviana (Pers) Schum. were extracted in four organic solvents; petroleum spirit, ethyl acetate, acetone and methanol and tested against the adults of Callosobruchus maculatus F. All the tested extracts effectively produced mortality of C. maculatus and their toxicity was in order of solvents: petroleum spirit>ethyl acetate>acetone>methanol. Root extract was the most toxic to C. maculatus. Females were more tolerant than males. Key words: Extract, mortality, solvent, Thevetia peruviana, Callosobruchus maculatus. DOI = 10.3329/jard.v5i1.1466 J Agric Rural Dev 5(1&2), 105-109, June 2007

scholarly journals Triterpenoids from the Stem Bark of Crataeva nurvala

1970 ◽  
Vol 7 (1) ◽  
pp. 71-74 ◽  
Author(s):  
Md Enamul Haque ◽  
Md Nahidul Islam ◽  
Dipankar Das Gupta ◽  
Mahbub Hossain ◽  
Hossain Uddin Shekhar ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Key Words ◽  
Silica Gel ◽  
1H Nmr ◽  
13C Nmr ◽  
Ethyl Acetate Extract ◽  
Stem Bark ◽  
First Report ◽  
Spectroscopic Analyses ◽  
Phytochemical Investigation

Two triterpenoids, phragmalin triacetate (1) and lupeol (2) were isolated from an ethyl acetate extract of the stem bark of Crataeva nurvala (Capparidaceae) by repeated chromatography over silica gel. The structures of these compounds were determined by spectroscopic analyses (UV, IR, 1H NMR, 13C NMR and EIMS). This is the first report of the systematic phytochemical investigation and the presence of these compounds 1 and 2 from this plant. Key words: Crataeva, Capparidaceae, Phragmalin triacetate and Lupeol.  DOI = 10.3329/dujps.v7i1.1221 Dhaka Univ. J. Pharm. Sci. 7(1): 71-74, 2008 (June)

New antifungal metabolites from the coprophilous fungus Cercophorasordarioides

1997 ◽  
Vol 75 (6) ◽  
pp. 768-772 ◽  
Author(s):  
Authrine C. Whyte ◽  
Katherine B. Gloer ◽  
James B. Gloer ◽  
Brenda Koster ◽  
David Malloch
Keyword(s):  
Ethyl Acetate ◽  
Key Words ◽  
Natural Product ◽  
Fungal Metabolite ◽  
Liquid Cultures ◽  
Antifungal Metabolites ◽  
Coprophilous Fungus ◽  
Bioassay Guided Fractionation ◽  
Related Compounds ◽  
Ethyl Acetate Extracts

A chemical investigation of the coprophilous fungus Cercophorasordarioides has led to the isolation of arthrinone (1), a known fungal metabolite, and three new related compounds: 1-dehydroxyarthrinone (2), 3a,9a-deoxy-3a-hydroxy-1-dehydroxyarthrinone (3), and cerdarin (4). These metabolites were obtained from antifungal ethyl acetate extracts of liquid cultures of C. sordarioides through bioassay-guided fractionation, and their structures were assigned on the basis of 1D-NMR, HMQC, and HMBC results. Compounds 2 and 4 exhibited anti-Candida activity. Key words: antifungal, fungal metabolite, natural product, Cercophorasordarioides.

Steriod and Triterpenoid from Anogeissus latifolia

1970 ◽  
Vol 6 (1) ◽  
pp. 47-50 ◽  
Author(s):  
Mohammad S Rahman ◽  
Mohammad Z Rahman ◽  
ABM Ahad Uddin ◽  
Mohammad A Rashid
Keyword(s):  
Ethyl Acetate ◽  
Key Words ◽  
Inhibitory Activity ◽  
Full Text ◽  
Brine Shrimp ◽  
Microbial Growth ◽  
Ethyl Acetate Extract ◽  
Stem Bark ◽  
Disc Diffusion ◽  
Antimicrobial Screening

3-?-hydroxy-28-acetyltaraxaren (1) and ?-sitosterol (2) were isolated from an ethyl acetate extract of the stem bark of Anogeissus latifolia. The ethyl acetate and methanol extracts when subjected to antimicrobial screening showed significant inhibitory activity to microbial growth, while the ethyl acetate showed demonstrated significant cytotoxicity to brine shrimp with LC50 of 0.50 ?g/ml. Key words: Anogeissus latifolia, Combretaceae, 3-?-hydroxy-28-acetyltaraxaren, ?-sitosterol, antimicrobial, cytotoxiciy, disc diffusion Dhaka Univ. J. Pharm. Sci. 6(1): 47-50, 2007 (June) The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Aktivitas Koagulan Ekstrak dan Fraksi Daun Sembung Rambat (Mikania micrantha Kunth.)

2019 ◽  
Vol 4 (1) ◽  
pp. 30-37
Author(s):  
Santi Perawati ◽  
Lili Andriani ◽  
Septa Pratama ◽  
Humayroh Humayroh
Keyword(s):  
Phenolic Compounds ◽  
Ethyl Acetate ◽  
Key Words ◽  
Ethanol Extract ◽  
Ethyl Acetate Fraction ◽  
Mikania Micrantha ◽  
Climbing Plant ◽  
Liquid Extract ◽  
Stop Time ◽  
Coagulant Activity

ABSTRAK Sembung Rambat (Mikania micrantha Kunth) merupakan tumbuhan yang tumbuh merambat mengandung zat aktif dalam bentuk metabolit sekunder seperti alkaloid, saponin, flavonoid, steroid, tanin, terpenoid dan kaya akan senyawa fenolik. Penelitian ini dilakukan untuk mengetahui kemampuan ekstrak dan fraksi dari daun sembung rambat sebagai koagulan. Ekstraksi daun segar sembung rambat menggunakan metode maserasi dengan pelarut etanol 96% , ekstrak etanol difraksinasi menggunakan metode ekstrak cair-cair dengan pelarut n-heksan, etil asetat dan n-butanol. Aktivitas koagulan diukur dengan cara melihat waktu terbentuk benang fibrin dan waktu henti darah pada hewan uji Mencit Putih Galur (Deutschland, Denkenand and Yoken). Ekstrak dengan dosis 60mg/20g BB mencit menunjukkan hasil aktivitas koagulan yang terbaik dibandingkan dengan variasi dosis lain dengan waktu terbentuk benang fibrin (77 detik) dan waktu henti darah (86 detik). Pada fraksi etil asetat memiliki aktivitas koagulan terbaik dibandingkan dengan ekstrak dan fraksi lain dengan waktu terbentuk benang fibrin (64 detik) dan waktu henti darah (86 detik). Ekstrak dan fraksi daun sembung rambat pada dosis 60mg/20g BB mencit memiliki aktivitas koagulan yang baik. Kata kunci: Koagulan, Sembung Rambat (Mikania micrantha Kunth.)     ABSTRACT Sembung Rambat (Mikania micrantha Kunth.) Is a climbing plant containing alkaloids, saponins, flavonoids, steroids, tannins, terpenoids and rich in phenolic compounds. This aim was to determine the ability of extracts and fractions of sembung rambat leaves as coagulant. Extraction of fresh leaves of used maceration method with ethanol 96% as a solvent, ethanol extract fractionated used liquid-liquid extract method with n-hexane, ethyl acetate and n-butanol. Coagulant activity was measured by looking at the time of formation of fibrin yarn and the time of blood stops in theanimals test of White Mice (Deutschland, Denkenand and Yoken). Extracts with a dose of 60 mg / 20 g BB mice showed the best results of coagulant activity compared to other dose variations with the time of formation of fibrin yarn 77 seconds and blood stop time 86 seconds. The ethyl acetate fraction has the best coagulant activity compared to extracts and other fractions with fibrin yarn formed time 64 seconds and blood stop time 86 seconds. In conclusion, the extracts and fractions of sembung rambat have coagulant activity.  Key words: Coagulant, Mikania micrantha Kunth

scholarly journals Screening of Phytochemical and Biological Potential of Clerodendron viscosum Leaves Extracts

1970 ◽  
Vol 45 (4) ◽  
pp. 381-386
Author(s):  
M Zahurul ◽  
MA Rouf ◽  
MA Jalil ◽  
M Badrul Islam ◽  
M Ruhul Islam
Keyword(s):  
Secondary Metabolites ◽  
Ethyl Acetate ◽  
Petroleum Ether ◽  
Key Words ◽  
Petroleum Ether Extract ◽  
Ether Extract ◽  
Stored Grain ◽  
Rhizopertha Dominica ◽  
Residual Film ◽  
Biological Potential

Attempts were made to investigate different phytochemicals (secondary metabolites) of Clerodendron viscosum leaves extracts with different solvents e.g. petroleum ether (40-60° C), ethyl acetate and chloroform. The extracts were found to contain alkaloids, carbohydrates, flavonoids, glycosides, tannins and steroids. The extracts were then subjected to bioactivity against some stored grain insect such as Tribolium castaneus, Sitophiulus oryzae, Rhizopertha dominica using the method of residual film technique. Among the extracts, the petroleum ether extract showed higher toxicity against Sitophiulus oryzae and Rhizopertha dominica but moderate toxicity against Tribolium castaneus. The ethyl acetate and chloroform extracts showed moderate toxicity against Sitophiulus oryzae. The effectiveness of the order of toxicity of the extracts was found to vary with different intervals of treatments (24, 48 and 72 hours). Key words: Clerodendron viscosum; Phyto-chemical; Bioactivity; Stored grain insect; Probit mortality DOI: 10.3329/bjsir.v45i4.7385 Bangladesh J. Sci. Ind. Res. 45(4), 381-386, 2010

3-Acetoxy-6-benzoyloxyapangamide from Achyranthes aspera

1970 ◽  
Vol 4 (2) ◽  
Author(s):  
Md. Abdul Aziz ◽  
Md. Mizanur Rahman ◽  
Anjon Kumar Mondal ◽  
Tanvir Muslim ◽  
Azizur Rahman ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ethyl Acetate ◽  
Bacillus Cereus ◽  
Key Words ◽  
Full Text ◽  
Ethyl Acetate Extract ◽  
Spectroscopic Techniques ◽  
Achyranthes Aspera ◽  
Isolated Compound

3-Acetoxy-6-benzoyloxyapangamide (1) has been isolated from an ethyl acetate extract of the stem of Achyranthes aspera. The structure of the isolated compound was established by modern spectroscopic techniques. The extract was found to show mild antibacterial activity against Bacillus cereus. Key words: Achyranthes aspera, 3-acetoxy-6-benzoyloxyapangamide, Antibacterial activity. Dhaka Univ. J. Pharm. Sci. Vol.4(2) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Antimicrobial activity of n-hexane and Ethyl acetate extracts of Erythrina stricta Roxb

1970 ◽  
Vol 27 (2) ◽  
pp. 65-66
Author(s):  
Mohammad Musarraf Hussain ◽  
M Mizanur Rahman Mughal ◽  
Md Masud Alam ◽  
Mohammad Golam Dastagir ◽  
AHM Masum Billah ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Ethyl Acetate ◽  
Key Words ◽  
Microbial Growth ◽  
Ethyl Acetate Extract ◽  
Stem Bark ◽  
Antimicrobial Activities ◽  
Zone Of Inhibition ◽  
Microbiological Investigation ◽  
Ethyl Acetate Extracts

The crude n-hexane and ethyl acetate extract of the stem bark of E. stricta were subjected to microbiological investigation and were found to be significantly inhibitory to microbial growth, with the average zone of inhibition 12–17 and 10–16 mm, respectively. In the cytotoxic observation, the n-hexane and ethyl acetate extracts were found to show LC50 of 2.1 and 0.316 mg/ml respectively. Key words: Erythrina stricta; Fabaceae; Antimicrobial activities; Cytotoxicity observation. DOI: http://dx.doi.org/10.3329/bjm.v27i2.9176 BJM 2010; 27(2): 65-66

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