Preferential inhibition of phosphatidyl ethanolamine synthesis in E. coli by alcohols

1977 ◽  
Vol 23 (6) ◽  
pp. 779-789 ◽  
Author(s):  
L. O. Ingram
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Phosphatidyl Ethanolamine ◽  
Phosphatidyl Serine ◽  
Total Fatty Acid Composition ◽  
E Coli ◽  
Phospholipid Classes ◽  
Induced Changes ◽  
Chain Lengths

Growth of E. coli in the presence of alcohols of chain lengths 1 through 8 results in an increase in the relative abundance of phosphatidyl glycerol. This results primarily from the preferential inhibition of phosphatidyl ethanolamine synthesis. This inhibition appears to be unrelated to membrane fluidity or to changes in fatty acid composition caused by alcohols. Alcohol-induced changes in total fatty acid composition are reflected in all phospholipid classes. Phosphatidyl serine synthetase is proposed as the most likely site for the effects of alcohols on phospholipid synthesis.

scholarly journals Phospholipid classes and fatty acid composition of ewe’s and goat’s milk

2013 ◽  
Vol 64 (3) ◽  
pp. 304-310 ◽  
Author(s):  
P. Hueso ◽  
L. Zancada ◽  
F. Pérez-Díez ◽  
F. Sánchez-Juanes ◽  
J. M. Alonso ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Goat’S Milk ◽  
Phospholipid Classes ◽  
Goat's Milk

Ethanol-induced changes in hepatic free radical defense mechanisms and fatty-acid composition in the miniature pig

Hepatology ◽  
1991 ◽  
Vol 13 (6) ◽  
pp. 1185-1192 ◽  
Author(s):  
Sheri Zidenberg-Cherr ◽  
Katherine L. Olin ◽  
Jesus Villanueva ◽  
Anna Tang ◽  
Stephen D. Phinney ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Free Radical ◽  
Acid Composition ◽  
Defense Mechanisms ◽  
Miniature Pig ◽  
Induced Changes

scholarly journals Impact of UV-B on drought- or cadmium-induced changes in the fatty acid composition of membrane lipid fractions in wheat

2014 ◽  
Vol 108 ◽  
pp. 129-134 ◽  
Author(s):  
Orsolya Kinga Gondor ◽  
Gabriella Szalai ◽  
Viktória Kovács ◽  
Tibor Janda ◽  
Magda Pál
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Membrane Lipid ◽  
Lipid Fractions ◽  
Induced Changes

THE TRANSPORT OF PHOSPHOLIPIDS FROM THE YOLK TO THE YOLK-SAC MEMBRANE DURING THE DEVELOPMENT OF THE CHICK EMBRYO

1967 ◽  
Vol 45 (7) ◽  
pp. 1125-1133 ◽  
Author(s):  
R. C. Noble ◽  
J. H. Moore
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Chick Embryo ◽  
Stearic Acid ◽  
Acid Composition ◽  
Phosphatidyl Choline ◽  
Phosphatidyl Ethanolamine ◽  
Yolk Sac ◽  
Membrane Phospholipids ◽  
Lysophosphatidyl Choline

A study was made of the concentrations and fatty acid compositions of the various phospholipid fractions in the yolks and yolk-sac membranes at different stages in the development of the chick embryo. Phosphatidyl choline was the major component of both the yolk and membrane phospholipids. The composition of the yolk phospholipids was broadly similar to that of the membrane phospholipids. In both the yolk and membrane phospholipids, the proportions of phosphatidyl choline and phosphatidyl ethanolamine tended to decrease, whereas the proportions of phosphatidyl serine, sphingomyelin, and lysophosphatidyl choline tended to increase as incubation proceeded. The fatty acid composition of the yolk phosphatidyl choline did not change during incubation, but there was a progressive decrease in the palmitic acid: stearic acid ratio in the membrane phosphatidyl choline. The changes in the fatty acid composition of the yolk phosphatidyl ethanolamine indicated that there was a preferential absorption from the yolk of phosphatidyl ethanolamine with stearic acid in the α position and arachidonic or docosahexaenoic acids in the β position. The lysophosphatidyl choline in the yolk and membrane evidently consisted of mixtures of the 1-acyl and 2-acyl isomers. There was no evidence that extensive breakdown and resynthesis of phospholipids occurred during the transport of lipids from the yolk to the yolk-sac membrane.

EFFECT OF FORCED RESTRAINT ON HEART PHOSPHOLIPIDS

1967 ◽  
Vol 45 (3) ◽  
pp. 407-413 ◽  
Author(s):  
P. Prioreschi ◽  
E. Peterman
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Phosphatidyl Ethanolamine ◽  
Resting Period

The cardiac level of phospholipids and their fatty acid composition were measured in the rat after different periods of forced restraint and different periods of rest. After 4 minutes of forced immobilization the level of heart cardiolipin decreased by about 75%. When the animal was immobilized for 24 hours the concentration of cardiolipin in the heart returned to normal after less than 96 hours of rest. The concentration of sphingomyelin was also decreased by forced restraint whereas phosphatidyl ethanolamine decreased only in the resting period after immobilization. The significance of these findings in the pathogenesis of experimental cardiac necroses is discussed.

scholarly journals An integrative approach points to membrane composition as a key factor in E. coli persistence

2020 ◽  
Author(s):  
SJ Cañas-Duarte ◽  
MI Perez-Lopez ◽  
C Herrfurth ◽  
Lei Sun ◽  
LM Contreras ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Stress Response ◽  
Acid Composition ◽  
Integrative Approach ◽  
Composition Analysis ◽  
List Type ◽  
Membrane Composition ◽  
Bacterial Persistence ◽  
E Coli

SummaryIn spite of its medical importance, the genetic mechanisms of bacterial persistence, particularly spontaneous (type II) persistence, remain largely unknown. We use an integrative approach, combining mutant genome analysis, transcriptomics and lipid membrane composition analysis, to elucidate said mechanisms. In particular, we analyzed the genome of the high persistence mutant E. coli DS1 (hipQ), to identify candidate mutations responsible for the high persistence phenotype. Contrary to a recent study, we find no mutation in ydcI. We compared the expression of spontaneous persistent and growing cells using RNAseq, and find that the activation of stress response mechanisms is likely less important in spontaneous persistence than recent reports suggest. It also indicated that modifications in the cell membrane could play an important role. This hypothesis was then validated by the analysis of the fatty acid composition of persister cells of both types, which have markedly different saturation from growing cells and between each other. Taken together, our results indicate that changing membrane composition might be a key process in persistence.HighlightsRNAseq analysis of spontaneous persistence shows no evidence of stress responseIdentification of candidate SNPs for hipQ phenotype, excludes ydcIMembrane fatty acid composition is involved in both types of bacterial persistence

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