Interaction of interferon with cells: the relationship of cell-associated interferon and antiviral activity

1970 ◽  
Vol 16 (12) ◽  
pp. 1303-1310 ◽  
Author(s):  
Edward T. Sheaff ◽  
Robert B. Stewart
Keyword(s):  
Chick Embryo ◽  
Antiviral Activity ◽  
Sindbis Virus ◽  
Quantitative Expression ◽  
Embryo Cells ◽  
Relationship Of ◽  
The Relationship

Studies of the effect of interferon on the growth of Sindbis virus in cultures of chick embryo cells have shown that interferon is taken up by cells and that such uptake must occur before antiviral activity is observed. Evidence is presented here that the quantitative expression of antiviral activity is dependent on the amount of interferon that becomes cell associated.

UV irradiation of interferon-treated chick embryo cells enhances sindbis virus growth

1976 ◽  
Vol 52 (4) ◽  
pp. 351-354
Author(s):  
Y. Umino ◽  
S. Kohno ◽  
S. Saito
Keyword(s):  
Chick Embryo ◽  
Uv Irradiation ◽  
Sindbis Virus ◽  
Virus Growth ◽  
Embryo Cells

Effect of interferon on Sindbis virus growth in chick-embryo cell cultures

1969 ◽  
Vol 15 (6) ◽  
pp. 605-610 ◽  
Author(s):  
Robert B. Stewart ◽  
Edward T. Sheaff
Keyword(s):  
Chick Embryo ◽  
Cell Cultures ◽  
Sindbis Virus ◽  
Embryo Cell ◽  
Virus Growth ◽  
Chick Embryo Cell ◽  
Embryo Cells ◽  
Number Of Cells

A study of the effect of interferon on the growth of Sindbis virus in cultures of chick-embryo cells has shown that interferon forms an association with cells (uptake) and that the action of interferon is concentration rather than amount dependent. Evidence has also been obtained that interferon acts to reduce the yield of virus from cells, but does not reduce the number of cells synthesizing virus (all or none effect).

scholarly journals The Relationship of Hyperthermia to Liver Growth and Liver Glycogen in the Chick Embryo

1967 ◽  
Vol 46 (6) ◽  
pp. 1454-1459 ◽  
Author(s):  
John M. Delphia ◽  
Shamer Singh ◽  
Harold Baskin
Keyword(s):  
Chick Embryo ◽  
Liver Glycogen ◽  
Liver Growth ◽  
Relationship Of ◽  
The Relationship

VARIATION IN SENSITIVITY OF AN INTERFERON ASSAY SYSTEM

1967 ◽  
Vol 13 (11) ◽  
pp. 1421-1425
Author(s):  
Robert B. Stewart ◽  
Sunidhkumar S. Gandhi
Keyword(s):  
Chick Embryo ◽  
Cell Cultures ◽  
Dose Response ◽  
Sindbis Virus ◽  
Primary Cultures ◽  
Assay System ◽  
Response Curves ◽  
Challenge Virus ◽  
Embryo Cells ◽  
Altered Sensitivity

Repeated assays of standard preparations of interferon carried out for over a year using primary cultures of chick-embryo cells and Sindbis virus in an assay system showed that cell cultures varied in their sensitivity to interferon. This altered sensitivity was not due to a change in the challenge virus nor to the time of exposure of cells to interferon. An analysis of the data showed that the slope of the dose–response curves remained constant although they could be displaced, indicating changes in sensitivity. Information was also obtained demonstrating that sensitivity of cells to interferon could vary within a single assay.

Lessons Learned and Recent Advances in Dengue Research

2020 ◽  
Author(s):  
Juan Samuel Sulca Herencia
Keyword(s):  
Climate Change ◽  
Viral Load ◽  
Antiviral Activity ◽  
Prevention And Control ◽  
Lessons Learned ◽  
New Drugs ◽  
Diagnostic Assays ◽  
And Control ◽  
Relationship Of ◽  
The Relationship

Dengue is the most important arbovirus, many research have contributed to the diagnosis, management, prevention and control of this disease, which will be described in this chapter, for example: the importance of serotypes and genotypes for the development of the disease, the relationship of the viral load between symptomatic and asymptomatic people, the influence of antibodies on the development of the disease, co-infections with microorganisms and chronic diseases, possible reservoirs, the diagnostic assays, cross-reactions in the diagnosis, the influence of climate change on the disease and the vector, mechanisms of transmission of the disease, new drugs and plant extracts with antiviral activity, the dengue vaccine, the results of immunizations, etc. This information gives a concrete idea of the advances and challenges against this disease.

The relationship of the scleractinian corals to the rugose corals

Paleobiology ◽  
1980 ◽  
Vol 6 (02) ◽  
pp. 146-160 ◽  
Author(s):  
William A. Oliver
Keyword(s):  
Critical Points ◽  
Scleractinian Corals ◽  
Convincing Evidence ◽  
Early Triassic ◽  
Rugose Corals ◽  
History Of ◽  
The Subject ◽  
Relationship Of ◽  
The Relationship ◽  
Biologic Factors

The Mesozoic-Cenozoic coral Order Scleractinia has been suggested to have originated or evolved (1) by direct descent from the Paleozoic Order Rugosa or (2) by the development of a skeleton in members of one of the anemone groups that probably have existed throughout Phanerozoic time. In spite of much work on the subject, advocates of the direct descent hypothesis have failed to find convincing evidence of this relationship. Critical points are:(1) Rugosan septal insertion is serial; Scleractinian insertion is cyclic; no intermediate stages have been demonstrated. Apparent intermediates are Scleractinia having bilateral cyclic insertion or teratological Rugosa.(2) There is convincing evidence that the skeletons of many Rugosa were calcitic and none are known to be or to have been aragonitic. In contrast, the skeletons of all living Scleractinia are aragonitic and there is evidence that fossil Scleractinia were aragonitic also. The mineralogic difference is almost certainly due to intrinsic biologic factors.(3) No early Triassic corals of either group are known. This fact is not compelling (by itself) but is important in connection with points 1 and 2, because, given direct descent, both changes took place during this only stage in the history of the two groups in which there are no known corals.

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