Influence of an arbovirus infection (Sindbis virus) on the protein and ribonucleic acid synthesis of cultivated chick embryo cells

1970 ◽  
Vol 31 (1-2) ◽  
pp. 81-92 ◽  
Author(s):  
M. Mussgay ◽  
P. -J. Enzmann ◽  
J. Horst
Keyword(s):  
Chick Embryo ◽  
Ribonucleic Acid ◽  
Sindbis Virus ◽  
Acid Synthesis ◽  
Embryo Cells ◽  
Arbovirus Infection

UV irradiation of interferon-treated chick embryo cells enhances sindbis virus growth

1976 ◽  
Vol 52 (4) ◽  
pp. 351-354
Author(s):  
Y. Umino ◽  
S. Kohno ◽  
S. Saito
Keyword(s):  
Chick Embryo ◽  
Uv Irradiation ◽  
Sindbis Virus ◽  
Virus Growth ◽  
Embryo Cells

Effect of interferon on Sindbis virus growth in chick-embryo cell cultures

1969 ◽  
Vol 15 (6) ◽  
pp. 605-610 ◽  
Author(s):  
Robert B. Stewart ◽  
Edward T. Sheaff
Keyword(s):  
Chick Embryo ◽  
Cell Cultures ◽  
Sindbis Virus ◽  
Embryo Cell ◽  
Virus Growth ◽  
Chick Embryo Cell ◽  
Embryo Cells ◽  
Number Of Cells

A study of the effect of interferon on the growth of Sindbis virus in cultures of chick-embryo cells has shown that interferon forms an association with cells (uptake) and that the action of interferon is concentration rather than amount dependent. Evidence has also been obtained that interferon acts to reduce the yield of virus from cells, but does not reduce the number of cells synthesizing virus (all or none effect).

Interaction of interferon with cells: the relationship of cell-associated interferon and antiviral activity

1970 ◽  
Vol 16 (12) ◽  
pp. 1303-1310 ◽  
Author(s):  
Edward T. Sheaff ◽  
Robert B. Stewart
Keyword(s):  
Chick Embryo ◽  
Antiviral Activity ◽  
Sindbis Virus ◽  
Quantitative Expression ◽  
Embryo Cells ◽  
Relationship Of ◽  
The Relationship

Studies of the effect of interferon on the growth of Sindbis virus in cultures of chick embryo cells have shown that interferon is taken up by cells and that such uptake must occur before antiviral activity is observed. Evidence is presented here that the quantitative expression of antiviral activity is dependent on the amount of interferon that becomes cell associated.

VARIATION IN SENSITIVITY OF AN INTERFERON ASSAY SYSTEM

1967 ◽  
Vol 13 (11) ◽  
pp. 1421-1425
Author(s):  
Robert B. Stewart ◽  
Sunidhkumar S. Gandhi
Keyword(s):  
Chick Embryo ◽  
Cell Cultures ◽  
Dose Response ◽  
Sindbis Virus ◽  
Primary Cultures ◽  
Assay System ◽  
Response Curves ◽  
Challenge Virus ◽  
Embryo Cells ◽  
Altered Sensitivity

Repeated assays of standard preparations of interferon carried out for over a year using primary cultures of chick-embryo cells and Sindbis virus in an assay system showed that cell cultures varied in their sensitivity to interferon. This altered sensitivity was not due to a change in the challenge virus nor to the time of exposure of cells to interferon. An analysis of the data showed that the slope of the dose–response curves remained constant although they could be displaced, indicating changes in sensitivity. Information was also obtained demonstrating that sensitivity of cells to interferon could vary within a single assay.

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