Training effects on peripheral muscle oxygenation and performance in children with congenital heart diseases

2012 ◽  
Vol 37 (4) ◽  
pp. 621-630 ◽  
Author(s):  
Wassim Moalla ◽  
Mohamed Elloumi ◽  
Karim Chamari ◽  
Grégory Dupont ◽  
Yves Maingourd ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Near Infrared ◽  
Heart Diseases ◽  
Vastus Lateralis ◽  
Muscle Oxygenation ◽  
Knee Extensors ◽  
Control Group ◽  
Time To Exhaustion ◽  
Congenital Heart Diseases ◽  
Peripheral Muscle

We investigated the effect of training on peripheral muscular performance and oxygenation during exercise and recovery in children with congenital heart diseases (CHD). Eighteen patients with CHD aged 12 to 15 years were randomly assigned into either an individualized 12-week aerobic cycling training group (TG) or a control group (CG). Maximal voluntary contraction (MVC) and endurance at 50% MVC (time to exhaustion, Tlim) of the knee extensors were measured before and after training. During the 50% MVC exercise and recovery, near-infrared spectroscopy (NIRS) was used to assess the fall in muscle oxygenation, i.e., deoxygenation ([Formula: see text]) of the vastus lateralis, the mean rate of decrease in muscle oxygenation, the half time of recovery (T1/2R), and the recovery speed to maximal oxygenation (RS). There was no effect of time on any parameter in the CG. After training, significant improvements were observed in TG for MVC (101.6 ± 14.0 vs. 120.2 ± 19.4 N·m, p < 0.01) and Tlim (66.2 ± 22.6 vs. 86.0 ± 23.0 s, p< 0.01). Increased oxygenation (0.20 ± 0.13 vs. 0.15 ± 0.07 a.u., p < 0.01) and faster mean rate of decrease in muscle oxygenation were also shown after training in TG (1.22 ± 0.45 vs. 1.71 ± 0.78%·s–1, p < 0.001). Moreover, a shorter recovery time was observed in TG after training for T1/2R (27.2 ± 6.1 vs. 20.8 ± 4.2 s, p < 0.01) and RS (63.1 ± 18.4 vs. 50.3 ± 11.4 s, p < 0.01). A significant relationship between the change in [Formula: see text] and both MVC (r = 0.95, p < 0.001) and Tlim (r = 0.90, p < 0.001) in TG was observed. We concluded that exercise training improves peripheral muscular function by enhancing strength and endurance performance in children with CHD. This improvement was associated with increased oxygenation of peripheral muscles and faster recovery.

Performance and Muscle Oxygenation during Isometric Exercise and Recovery in Children with Congenital Heart Diseases

2006 ◽  
Vol 27 (11) ◽  
pp. 864-869 ◽  
Author(s):  
W. Moalla ◽  
G. Dupont ◽  
F. Costes ◽  
R. Gauthier ◽  
Y. Maingourd ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Isometric Exercise ◽  
Muscle Oxygenation ◽  
Congenital Heart Diseases

P1796Adults with congenital heart disease have impaired calf muscle oxygenation compared to control subjects

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C Sandberg ◽  
A G Crenshaw ◽  
G H Elcadi ◽  
C Christersson ◽  
J Hlebowicz ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Blood Flow ◽  
Heart Disease ◽  
Exercise Capacity ◽  
Congenital Heart ◽  
Near Infrared ◽  
Venous Occlusion ◽  
Calf Muscle ◽  
Muscle Oxygenation ◽  
Peripheral Muscle

Abstract Background Peripheral muscle factors are presumed to be important contributors to the reduced exercise capacity in congenital heart disease (CHD), but the mechanisms are poorly understood. Purpose To investigate if muscle oxygenation in the calf muscle is impaired in adults with complex CHD in comparison to controls. Method Seventy-four adults with complex CHD (35.6±14.3 years, females n=22) were recruited from centers specialized in adult CHD. Seventy-four age and gender matched subjects were recruited as controls. Muscle oxygenation was successfully determined using near-infrared spectroscopy on the medial portion of m. gastrocnemiusin 63 patients and 67 controls. Measurements were made at rest, during venous occlusion to estimate blood flow (BF – indicated by the slope increase of total haemoglobin, HbT), at the start of isotonic unilateral heel-lifts to exhaustion, and immediately after exercise. Results In comparison to controls, patients had a lower muscle saturation (StO2) at rest, albeit not statistically significant, (66±17% vs. 60±19%, p=0.07), and a lower BF (0.38±0.21 vs. 0.31±0.21 HbTx3.5sec–1, p=0.07). For exercise, compared to the controls, patients had a slower desaturation rate at exercise onset (−11.7±5.8% vs. −7.7±4.3%. StO2x3.5sec–1, p<0.001), and both a slower resaturation rate (6.1±3.8% vs. 3.9±3.7% StO2x3.5sec–1, p=0.002) and a slower half recovery time (16.8±11.1 vs. 28.6±21.2 sec, p<0.001) post exercise. Conclusion The lower muscle oxygenation and blood flow at rest, and the slower oxygenation kinetics during exercise may give insight to the mechanism for the reduced exercise capacity commonly found in adults with complex CHD. This finding may also provide implications for design of rehabilitation programs for these patients.

scholarly journals Myocardial Injury in Children with Unoperated Congenital Heart Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Mohamed O. Hafez ◽  
Saed M. Morsy ◽  
Ragab A. Mahfoz ◽  
Ahmed R. Ali
Keyword(s):  
Congenital Heart ◽  
Myocardial Injury ◽  
Heart Diseases ◽  
Pressure Overload ◽  
Systemic Arterial Pressure ◽  
Control Group ◽  
Congenital Heart Diseases ◽  
Healthy Children ◽  
Early Management ◽  
And Control

Background.Children with congenital heart diseases (CHDs) may have a risk of developing myocardial injury caused by volume and pressure overload.Objective.To evaluate the incidence of myocardial injury in children with cyanotic and acyanotic CHDs using cTnI assay and to correlate it with different hemodynamic parameters.Methods.This study included 80 children with CHDs (40 acyanotic and 40 cyanotic) as well as 40 healthy children (control group). Serum cTnI levels were measured for patients and control. Pulmonary to systemic blood flow (Qp/Qs) and pulmonary to systemic arterial pressure (Pp/Ps) ratios were measured for children with CHDs during cardiac catheterization.Results.Sixty-four out of 80 patients with CHDs had myocardial injury as evidenced by increased cTnI. Serum cTnI was significantly higher in both cyanotic and acyanotic groups compared to control group (p<0.05). Serum cTnI level significantly correlated with oxygen saturation (SpO2), ejection fraction (EF), Qp/Qs, and Pp/Ps ratios.Conclusion.The incidence of myocardial injury was high in children with CHDs. The use of cTnI for follow-up of children with CHDs may help early detection of myocardial injury and help early management of these cases.

scholarly journals HOTAIR Is a Potential Novel Biomarker in Patients with Congenital Heart Diseases

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Yu Jiang ◽  
Hongdan Mo ◽  
Jing Luo ◽  
Suhong Zhao ◽  
Shuang Liang ◽  
...  
Keyword(s):  
Heart Development ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Right Atrial ◽  
Control Group ◽  
Congenital Heart Diseases ◽  
Cardiac Tissues ◽  
Polycomb Repressive Complex 2 ◽  
Valvular Heart Diseases ◽  
Right Atrial Appendage

Objective. To investigate the expression of HOX transcript antisense RNA (HOTAIR) in cardiac tissues and plasma of patients with congenital heart diseases (CHDs). Methods. qRT-PCR was used to detect the expression of HOTAIR in right atrial appendage tissues of 16 patients with CHDs and 14 patients with rheumatic valvular heart diseases (RVHDs), as well as in plasma of 36 normal people and 90 patients with CHDs including 36 cases of ASD, 23 cases of VSD, and 31 cases of PDA. Besides, the proteins interacting with HOTAIR were obtained from databases. Results. The HOTAIR expression in cardiac tissues of CHDs group was significantly higher than that of the RVHDs group (P<0.01). Compared with the control group, the expression of plasma HOTAIR in the ASD group, the VSD group, and the PDA group was all remarkably upregulated (P<0.01), whereas there was no relationship between HOTAIR and pulmonary arterial hypertension and defects size. Databases show that HOTAIR is associated with polycomb repressive complex 2 (PRC2) which contributes to heart development. Conclusion. The levels of HOTAIR were increased in cardiac tissues and plasma of patients with CHDs. HOTAIR is a potential novel diagnostic biomarker in patients with CHDs.

scholarly journals Study on Maternal SNPs of MTHFR Gene and HCY Level Related to Congenital Heart Diseases

2020 ◽  
Author(s):  
Hui Shi ◽  
Shiwei Yang ◽  
Ning Lin ◽  
Peng Huang ◽  
Rongbin Yu ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Drug Exposure ◽  
Heart Diseases ◽  
Mthfr Gene ◽  
Control Group ◽  
Homozygous Mutation ◽  
Control Analysis ◽  
Congenital Heart Diseases ◽  
History Of ◽  
The Relationship

AbstractThe aim of this study is to evaluate the relationship between maternal single nucleotide polymorphisms (SNPs) of methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine (HCY) level and offspring congenital heart diseases (CHDs). 338 mothers with offspring CHDs as case group and 306 mothers of normal children as control group were recruited. Their pregnant histories were interviewed by questionnaire and the MTHFR rsl801133 and rsl801131 were genotyped. The case–control analysis was used to find out the relationship between maternal SNPs of MTHFR gene and offspring CHDs. And the plasma HCY concentration of the mothers of CHDs children was detected. This case–case study was intended to find out the relevance between maternal HCY level and SNPs of MTHFR gene. There were significant differences in the gender of children, occupation of mothers, family history with CHDs, history of abortion, history of adverse pregnancy, early pregnancy health, fetus during pregnancy, pesticide exposure and drug exposure in CHDs group and control group (P < 0.05). MTHFR rs1801133 was significantly associated with their offspring CHDs in mothers. The polymorphism of maternal MTHFR rs1801133 increased plasma HCY level, especially the homozygous mutation. Besides the environmental factors, our results suggested that the maternal MTHFR rs1801133 polymorphism might be a risk factor of their offspring CHDs, which may be due to the hyperhomocysteinemia by abnormal metabolism of HCY.

scholarly journals Assessment of Dental Status and Oral Health Status in Children with Congenital Heart Diseases

2019 ◽  
pp. 42-58
Author(s):  
Sreenita Chowdhury ◽  
Binita Srivastava ◽  
Siddhartha Pujari ◽  
Nidhi Gupta ◽  
Rashi Singh ◽  
...  
Keyword(s):  
Rural Areas ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Dental Health ◽  
Oral Health Status ◽  
Permanent Dentition ◽  
Control Group ◽  
Congenital Heart Diseases ◽  
Healthy Children ◽  
Cardiac Group

Purpose: This study aims to identify the dental caries, decayed, missing, and filled teeth index (dmft/DMFT) scores amongst children with cyanotic, and acyanotic congenital heart diseases (CHD), compare with healthy controls and identify the risk factors for poor dental health. Methods: Between January 2016 and June 2017, 236 children aged 2 to 15 years (mean±SD=7.61±3.88 yrs, median 7 yrs) with CHD and 951 healthy children aged 2 to 15 years (mean±SD=8.83±7.34 yrs, median 9 yrs) were evaluated. Results: Children with CHD had more caries in their primary and permanent dentition (mean dmft: 2.42±3.82, cardiac group vs. 2.32±6.68, control group; p<0·05; mean DMFT: 2.15±3.38, cardiac group vs. 1.27±1.89, control group; p=0.002). The DMFT scores for children with CHD were higher in the rural areas. Children frequently consuming biscuits, confectionary and sugared milk had higher dmft±SD scores. The possibility of caries in permanent dentition was more in children with cyanotic CHD compared to acyanotic. Caries in primary dentition showed positive correlation with age. Conclusions: CHD is associated with poorer dental health in children. Close cooperation between pediatric cardiologists and pediatric dentists is warranted to raise awareness, prevent and institute early treatment for dental ailments.

Assessment of exercise capacity and respiratory muscle oxygenation in healthy children and children with congenital heart diseases

2008 ◽  
Vol 33 (3) ◽  
pp. 434-440 ◽  
Author(s):  
Wassim Moalla ◽  
Grégory Dupont ◽  
Abdou Temfemo ◽  
Yves Maingourd ◽  
Matthew Weston ◽  
...  
Keyword(s):  
Exercise Capacity ◽  
Power Output ◽  
Respiratory Muscle ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Respiratory Muscles ◽  
Muscle Oxygenation ◽  
Exercise Intolerance ◽  
Congenital Heart Diseases ◽  
Healthy Children

Muscular and cardiorespiratory dysfunction contributes to exercise intolerance. Therefore, the aim of the present study was to characterize the cardiopulmonary response andrespiratory muscle oxygenation of children with congenital heart diseases (CHD) when compared with those of healthy children. Twelve children with CHD in New York Heart Association (NYHA) class II or III, and 14 healthy children participated in the study. All subjects performed conventional spirographic measurements and a cardiopulmonary exercise test on a cycle ergometer. Oxygen uptake (VO2), carbon dioxide production (VCO2), minute ventilation (VE), heart rate (HR), and power output were measured. Oxygenation of respiratory muscles was assessed by near-infrared spectroscopy (NIRS) during exercise and recovery. Pulmonary function was normal and no significant difference was found between groups. At rest, CHD patients had cardiorespiratory variables comparable with those of the healthy group. At submaximal intensity (ventilatory threshold) and at peak exercise, power output, HR, VO2, VCO2, and VE were significantly reduced (p < 0.01) in CHD patients. Respiratory muscles deoxygenated during exercise in both groups. However, deoxygenation was more pronounced in the CHD group than in the healthy children from an intensity of 40% up to exhaustion. Likewise, children with CHD showed a slower recovery of oxygenation than healthy children (113.4 ± 17.5 vs. 74.6 ± 13.0 s; p < 0.001). Compared with healthy children, these results demonstrated that children with CHD have reduced performance and present a defected exercise capacity. Children with CHD showed a more pronounced decrease of respiratory muscle oxygenation and slower recovery of oxygen kinetics.

Spiritually Sensitive Intervention to Mitigate Depressive Symptoms Among Hospitalized Children Affected With Congenital Heart Diseases: Insights for Holistic Pediatric Nursing

2019 ◽  
Vol 38 (1) ◽  
pp. 78-88
Author(s):  
Samta P. Pandya
Keyword(s):  
Depressive Symptoms ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Control Group ◽  
Hospitalized Children ◽  
Congenital Heart Diseases ◽  
Ventricular Septal Defects ◽  
Pediatric Nursing ◽  
Septal Defects ◽  
Pediatric Hospitals

This article reports on an experiment in 28 pediatric hospitals across 14 African and Asian cities. The aim was to examine the effect of a customized spiritually sensitive intervention (SSI) on mitigating depressive symptoms among hospitalized children with congenital heart diseases (CHD). Results showed that post-SSI, 1,139 treatment group children were less depressed vis-à-vis the control group. The SSI was more effective for children from African cities, boys, middle class, Christians and Buddhists, those undergoing medical care for ventricular septal defects, children who stayed in the hospital for 2 to 3 weeks and who regularly self-practiced the lessons after hospital discharge. The SSI could be effectively used for holistic pediatric nursing and health care across contexts with CHD affected children, with some culture-specific variations for greater impact.

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