Assessment of exercise capacity and respiratory muscle oxygenation in healthy children and children with congenital heart diseases

2008 ◽  
Vol 33 (3) ◽  
pp. 434-440 ◽  
Author(s):  
Wassim Moalla ◽  
Grégory Dupont ◽  
Abdou Temfemo ◽  
Yves Maingourd ◽  
Matthew Weston ◽  
...  
Keyword(s):  
Exercise Capacity ◽  
Power Output ◽  
Respiratory Muscle ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Respiratory Muscles ◽  
Muscle Oxygenation ◽  
Exercise Intolerance ◽  
Congenital Heart Diseases ◽  
Healthy Children

Muscular and cardiorespiratory dysfunction contributes to exercise intolerance. Therefore, the aim of the present study was to characterize the cardiopulmonary response andrespiratory muscle oxygenation of children with congenital heart diseases (CHD) when compared with those of healthy children. Twelve children with CHD in New York Heart Association (NYHA) class II or III, and 14 healthy children participated in the study. All subjects performed conventional spirographic measurements and a cardiopulmonary exercise test on a cycle ergometer. Oxygen uptake (VO2), carbon dioxide production (VCO2), minute ventilation (VE), heart rate (HR), and power output were measured. Oxygenation of respiratory muscles was assessed by near-infrared spectroscopy (NIRS) during exercise and recovery. Pulmonary function was normal and no significant difference was found between groups. At rest, CHD patients had cardiorespiratory variables comparable with those of the healthy group. At submaximal intensity (ventilatory threshold) and at peak exercise, power output, HR, VO2, VCO2, and VE were significantly reduced (p < 0.01) in CHD patients. Respiratory muscles deoxygenated during exercise in both groups. However, deoxygenation was more pronounced in the CHD group than in the healthy children from an intensity of 40% up to exhaustion. Likewise, children with CHD showed a slower recovery of oxygenation than healthy children (113.4 ± 17.5 vs. 74.6 ± 13.0 s; p < 0.001). Compared with healthy children, these results demonstrated that children with CHD have reduced performance and present a defected exercise capacity. Children with CHD showed a more pronounced decrease of respiratory muscle oxygenation and slower recovery of oxygen kinetics.

Performance and Muscle Oxygenation during Isometric Exercise and Recovery in Children with Congenital Heart Diseases

2006 ◽  
Vol 27 (11) ◽  
pp. 864-869 ◽  
Author(s):  
W. Moalla ◽  
G. Dupont ◽  
F. Costes ◽  
R. Gauthier ◽  
Y. Maingourd ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Isometric Exercise ◽  
Muscle Oxygenation ◽  
Congenital Heart Diseases

Training effects on peripheral muscle oxygenation and performance in children with congenital heart diseases

2012 ◽  
Vol 37 (4) ◽  
pp. 621-630 ◽  
Author(s):  
Wassim Moalla ◽  
Mohamed Elloumi ◽  
Karim Chamari ◽  
Grégory Dupont ◽  
Yves Maingourd ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Near Infrared ◽  
Heart Diseases ◽  
Vastus Lateralis ◽  
Muscle Oxygenation ◽  
Knee Extensors ◽  
Control Group ◽  
Time To Exhaustion ◽  
Congenital Heart Diseases ◽  
Peripheral Muscle

We investigated the effect of training on peripheral muscular performance and oxygenation during exercise and recovery in children with congenital heart diseases (CHD). Eighteen patients with CHD aged 12 to 15 years were randomly assigned into either an individualized 12-week aerobic cycling training group (TG) or a control group (CG). Maximal voluntary contraction (MVC) and endurance at 50% MVC (time to exhaustion, Tlim) of the knee extensors were measured before and after training. During the 50% MVC exercise and recovery, near-infrared spectroscopy (NIRS) was used to assess the fall in muscle oxygenation, i.e., deoxygenation ([Formula: see text]) of the vastus lateralis, the mean rate of decrease in muscle oxygenation, the half time of recovery (T1/2R), and the recovery speed to maximal oxygenation (RS). There was no effect of time on any parameter in the CG. After training, significant improvements were observed in TG for MVC (101.6 ± 14.0 vs. 120.2 ± 19.4 N·m, p < 0.01) and Tlim (66.2 ± 22.6 vs. 86.0 ± 23.0 s, p< 0.01). Increased oxygenation (0.20 ± 0.13 vs. 0.15 ± 0.07 a.u., p < 0.01) and faster mean rate of decrease in muscle oxygenation were also shown after training in TG (1.22 ± 0.45 vs. 1.71 ± 0.78%·s–1, p < 0.001). Moreover, a shorter recovery time was observed in TG after training for T1/2R (27.2 ± 6.1 vs. 20.8 ± 4.2 s, p < 0.01) and RS (63.1 ± 18.4 vs. 50.3 ± 11.4 s, p < 0.01). A significant relationship between the change in [Formula: see text] and both MVC (r = 0.95, p < 0.001) and Tlim (r = 0.90, p < 0.001) in TG was observed. We concluded that exercise training improves peripheral muscular function by enhancing strength and endurance performance in children with CHD. This improvement was associated with increased oxygenation of peripheral muscles and faster recovery.

scholarly journals Myocardial Injury in Children with Unoperated Congenital Heart Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Mohamed O. Hafez ◽  
Saed M. Morsy ◽  
Ragab A. Mahfoz ◽  
Ahmed R. Ali
Keyword(s):  
Congenital Heart ◽  
Myocardial Injury ◽  
Heart Diseases ◽  
Pressure Overload ◽  
Systemic Arterial Pressure ◽  
Control Group ◽  
Congenital Heart Diseases ◽  
Healthy Children ◽  
Early Management ◽  
And Control

Background.Children with congenital heart diseases (CHDs) may have a risk of developing myocardial injury caused by volume and pressure overload.Objective.To evaluate the incidence of myocardial injury in children with cyanotic and acyanotic CHDs using cTnI assay and to correlate it with different hemodynamic parameters.Methods.This study included 80 children with CHDs (40 acyanotic and 40 cyanotic) as well as 40 healthy children (control group). Serum cTnI levels were measured for patients and control. Pulmonary to systemic blood flow (Qp/Qs) and pulmonary to systemic arterial pressure (Pp/Ps) ratios were measured for children with CHDs during cardiac catheterization.Results.Sixty-four out of 80 patients with CHDs had myocardial injury as evidenced by increased cTnI. Serum cTnI was significantly higher in both cyanotic and acyanotic groups compared to control group (p<0.05). Serum cTnI level significantly correlated with oxygen saturation (SpO2), ejection fraction (EF), Qp/Qs, and Pp/Ps ratios.Conclusion.The incidence of myocardial injury was high in children with CHDs. The use of cTnI for follow-up of children with CHDs may help early detection of myocardial injury and help early management of these cases.

scholarly journals Association and interaction effect of UCP2 gene polymorphisms and dietary factors with congenital heart diseases in Chinese Han population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Senmao Zhang ◽  
Xiaoying Liu ◽  
Tingting Wang ◽  
Lizhang Chen ◽  
Tubao Yang ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Dietary Factors ◽  
Unknown Etiology ◽  
Congenital Heart Diseases ◽  
Healthy Children ◽  
Positive Interaction ◽  
Ucp2 Gene ◽  
Excessive Intake ◽  
Pickled Vegetables

AbstractCongenital heart diseases (CHDs) are the most common birth defects and the leading cause of non-infectious deaths in infants, with an unknown etiology. We aimed to assess the association of genetic variations in UCP2 gene, dietary factors, and their interactions with the risk of CHDs in offspring. The hospital-based case–control study included 464 mothers of children with CHDs and 504 mothers of healthy children. The exposures of interest were maternal dietary factors in early pregnancy and UCP2 genetic variants. Logistic regression analyses were used to assess the association and interaction of UCP2 gene and dietary factors with CHDs. Our results found that the polymorphisms of UCP2 gene at rs659366 and rs660339, together with maternal dietary factors including excessive intake of pickled vegetables and smoked foods were associated with increased risks of CHDs in offspring. Regular intake of fresh meat, fish and shrimp, and milk products were associated with lower risks of CHDs in offspring. Besides, positive interaction between the dominant model of rs659366 and excessive intake of pickled vegetables was found in the additive interaction model (RERI = 1.19, P = 0.044). These findings provide the theoretical basis for gene screening and a new clue for the prevention of CHDs in offspring.

scholarly journals Analysis of the interconnection of the GSTP1, CYP1A2, CYP1A1 genes in children with congenital heart diseases

2020 ◽  
Vol 65 (3) ◽  
pp. 39-43
Author(s):  
A. V. Tsepokina ◽  
A. V. Ponasenko ◽  
A. V. Shabaldin
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Heart Defects ◽  
Congenital Heart Diseases ◽  
Genotype Distribution ◽  
Healthy Children ◽  
Rt Pcr ◽  
Locus Model ◽  
Healthy Donors ◽  
Pcr Method

The article presents data on the study of gene interconnections between the xenobiotics detoxification genes in various phases.Materials and methods. The study involves 131 children with congenital heart diseases (CHD) and 103 conditionally healthy children. The genotyping was performed by RT-PCR method using TaqMan probes. Intergenic bonds were analyzed via MDR v.3.0.2.Results and conclusion. We discovered no statistically significant differences in the genotype distribution in children with CHD and conditionally healthy donors. The analysis of intergenic interactions helped to develop a five-locus model characterized by the highest reproducibility, sensitivity and specificity: GSTP1 rs1793068 – GSTP1 rs6591256 – GSTP1 rs1871042 – CYP1A1 rs1048943 – CYP1A2 rs762551. This model was used to determine a number of protective and risky combinations of congenital heart defects-associated genotypes in children.

scholarly journals Cardiopulmonary fitness in children with congenital heart diseases versus healthy children

Heart ◽  
2017 ◽  
Vol 104 (12) ◽  
pp. 1026-1036 ◽  
Author(s):  
Pascal Amedro ◽  
Arthur Gavotto ◽  
Sophie Guillaumont ◽  
Helena Bertet ◽  
Marie Vincenti ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Female Gender ◽  
Cardiopulmonary Exercise Test ◽  
Congenital Heart Diseases ◽  
Healthy Children ◽  
Normal Children ◽  
Cross Sectional ◽  
Cardiopulmonary Fitness

ObjectiveWe aimed to compare the cardiopulmonary fitness of children with congenital heart diseases (CHD) with that of age-adjusted and gender-adjusted controls. We also intended to identify clinical characteristics associated with maximum oxygen uptake (VO2max) in this population.Methods and resultsWe included in a cross-sectional multicentre study a total of 798 children (496 CHD and 302 controls) who underwent a complete cardiopulmonary exercise test (CPET). The association of clinical characteristics with VO2max was studied using a multivariate analysis. Mean VO2max in the CHD group and control represented 93%±20% and 107%±17% of predicted values, respectively. VO2max was significantly lower in the CHD group, overall (37.8±0.3vs 42.6±0.4 mL/kg/min, P<0.0001) and for each group (P<0.05). The mean VO2max decline per year was significantly higher in CHD than in the controls overall (−0.84±0.10 vs −0.19±0.14 mL/kg/min/year, P<0.01), for boys (−0.72±0.14vs 0.11±0.19 mL/kg/min/year, P<0.01) and for girls (−1.00±0.13 vs −0.55±0.21 mL/kg/min/year, P=0.05). VO2max was associated with body mass index, ventilatory anaerobic threshold, female gender, restrictive ventilatory disorder, right ventricle systolic hypertension, tricuspid regurgitation, the number of cardiac catheter or surgery procedures, and the presence of a genetic anomaly.ConclusionsAlthough the magnitude of the difference was not large, VO2max among children with CHD was significantly lower than in normal children. We suggest performing CPET in routine follow-up of these patients.Trial registration numberClinicalTrials.gov NCT01202916; Post-results.

scholarly journals Assessment of Dental Status and Oral Health Status in Children with Congenital Heart Diseases

2019 ◽  
pp. 42-58
Author(s):  
Sreenita Chowdhury ◽  
Binita Srivastava ◽  
Siddhartha Pujari ◽  
Nidhi Gupta ◽  
Rashi Singh ◽  
...  
Keyword(s):  
Rural Areas ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Dental Health ◽  
Oral Health Status ◽  
Permanent Dentition ◽  
Control Group ◽  
Congenital Heart Diseases ◽  
Healthy Children ◽  
Cardiac Group

Purpose: This study aims to identify the dental caries, decayed, missing, and filled teeth index (dmft/DMFT) scores amongst children with cyanotic, and acyanotic congenital heart diseases (CHD), compare with healthy controls and identify the risk factors for poor dental health. Methods: Between January 2016 and June 2017, 236 children aged 2 to 15 years (mean±SD=7.61±3.88 yrs, median 7 yrs) with CHD and 951 healthy children aged 2 to 15 years (mean±SD=8.83±7.34 yrs, median 9 yrs) were evaluated. Results: Children with CHD had more caries in their primary and permanent dentition (mean dmft: 2.42±3.82, cardiac group vs. 2.32±6.68, control group; p<0·05; mean DMFT: 2.15±3.38, cardiac group vs. 1.27±1.89, control group; p=0.002). The DMFT scores for children with CHD were higher in the rural areas. Children frequently consuming biscuits, confectionary and sugared milk had higher dmft±SD scores. The possibility of caries in permanent dentition was more in children with cyanotic CHD compared to acyanotic. Caries in primary dentition showed positive correlation with age. Conclusions: CHD is associated with poorer dental health in children. Close cooperation between pediatric cardiologists and pediatric dentists is warranted to raise awareness, prevent and institute early treatment for dental ailments.

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