scholarly journals HOTAIR Is a Potential Novel Biomarker in Patients with Congenital Heart Diseases

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Yu Jiang ◽  
Hongdan Mo ◽  
Jing Luo ◽  
Suhong Zhao ◽  
Shuang Liang ◽  
...  
Keyword(s):  
Heart Development ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Right Atrial ◽  
Control Group ◽  
Congenital Heart Diseases ◽  
Cardiac Tissues ◽  
Polycomb Repressive Complex 2 ◽  
Valvular Heart Diseases ◽  
Right Atrial Appendage

Objective. To investigate the expression of HOX transcript antisense RNA (HOTAIR) in cardiac tissues and plasma of patients with congenital heart diseases (CHDs). Methods. qRT-PCR was used to detect the expression of HOTAIR in right atrial appendage tissues of 16 patients with CHDs and 14 patients with rheumatic valvular heart diseases (RVHDs), as well as in plasma of 36 normal people and 90 patients with CHDs including 36 cases of ASD, 23 cases of VSD, and 31 cases of PDA. Besides, the proteins interacting with HOTAIR were obtained from databases. Results. The HOTAIR expression in cardiac tissues of CHDs group was significantly higher than that of the RVHDs group (P<0.01). Compared with the control group, the expression of plasma HOTAIR in the ASD group, the VSD group, and the PDA group was all remarkably upregulated (P<0.01), whereas there was no relationship between HOTAIR and pulmonary arterial hypertension and defects size. Databases show that HOTAIR is associated with polycomb repressive complex 2 (PRC2) which contributes to heart development. Conclusion. The levels of HOTAIR were increased in cardiac tissues and plasma of patients with CHDs. HOTAIR is a potential novel diagnostic biomarker in patients with CHDs.

Plasma Atrial Natriuretic Peptide in Patients With Congenital Heart Diseases

PEDIATRICS ◽  
1988 ◽  
Vol 82 (4) ◽  
pp. 639-643
Author(s):  
Suguru Matsuoka ◽  
Yoshihide Kurahashi ◽  
Yohko Miki ◽  
Masuhide Miyao ◽  
Yasuhiro Yamazaki ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Congenital Heart ◽  
Septal Defect ◽  
Heart Diseases ◽  
Ductus Arteriosus ◽  
Right Atrial ◽  
Congenital Heart Diseases ◽  
Septal Defects ◽  
Atrial Natriuretic

The plasma level of human α-atrial natriuretic peptide was measured in healthy children and patients, 1 month to 15 years of age, with congenital heart diseases. Significant increases were found in patients with a ventricular septal defect, tricuspid valve atresia, patent ductus arteriosus, and atrial septal defect but not in those with pulmonary valve stenosis or tetralogy of Fallot. The levels were significantly higher in children with ventricular septal defects (221 ± 123 pg/mL) or patent ductus arteriosus (124 ± 38 pg/mL) than in those with atrial septal defects (65 ± 42 pg/mL) (P &lt; .01). The increased levels appeared to be correlated with enlargement of the left atrium (r = .85, P &lt; .01) but not with the right atrial size or the mean right atrial pressure. They were higher in younger than in older healthy infants, but this age difference did not affect the results. These findings indicate that human α-atrial natriuretic peptide is released into the circulation in response to chronic atrial expansion in patients with congenital heart disease and may have an important role in volume homeostasis.

Training effects on peripheral muscle oxygenation and performance in children with congenital heart diseases

2012 ◽  
Vol 37 (4) ◽  
pp. 621-630 ◽  
Author(s):  
Wassim Moalla ◽  
Mohamed Elloumi ◽  
Karim Chamari ◽  
Grégory Dupont ◽  
Yves Maingourd ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Near Infrared ◽  
Heart Diseases ◽  
Vastus Lateralis ◽  
Muscle Oxygenation ◽  
Knee Extensors ◽  
Control Group ◽  
Time To Exhaustion ◽  
Congenital Heart Diseases ◽  
Peripheral Muscle

We investigated the effect of training on peripheral muscular performance and oxygenation during exercise and recovery in children with congenital heart diseases (CHD). Eighteen patients with CHD aged 12 to 15 years were randomly assigned into either an individualized 12-week aerobic cycling training group (TG) or a control group (CG). Maximal voluntary contraction (MVC) and endurance at 50% MVC (time to exhaustion, Tlim) of the knee extensors were measured before and after training. During the 50% MVC exercise and recovery, near-infrared spectroscopy (NIRS) was used to assess the fall in muscle oxygenation, i.e., deoxygenation ([Formula: see text]) of the vastus lateralis, the mean rate of decrease in muscle oxygenation, the half time of recovery (T1/2R), and the recovery speed to maximal oxygenation (RS). There was no effect of time on any parameter in the CG. After training, significant improvements were observed in TG for MVC (101.6 ± 14.0 vs. 120.2 ± 19.4 N·m, p < 0.01) and Tlim (66.2 ± 22.6 vs. 86.0 ± 23.0 s, p< 0.01). Increased oxygenation (0.20 ± 0.13 vs. 0.15 ± 0.07 a.u., p < 0.01) and faster mean rate of decrease in muscle oxygenation were also shown after training in TG (1.22 ± 0.45 vs. 1.71 ± 0.78%·s–1, p < 0.001). Moreover, a shorter recovery time was observed in TG after training for T1/2R (27.2 ± 6.1 vs. 20.8 ± 4.2 s, p < 0.01) and RS (63.1 ± 18.4 vs. 50.3 ± 11.4 s, p < 0.01). A significant relationship between the change in [Formula: see text] and both MVC (r = 0.95, p < 0.001) and Tlim (r = 0.90, p < 0.001) in TG was observed. We concluded that exercise training improves peripheral muscular function by enhancing strength and endurance performance in children with CHD. This improvement was associated with increased oxygenation of peripheral muscles and faster recovery.

scholarly journals Myocardial Injury in Children with Unoperated Congenital Heart Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Mohamed O. Hafez ◽  
Saed M. Morsy ◽  
Ragab A. Mahfoz ◽  
Ahmed R. Ali
Keyword(s):  
Congenital Heart ◽  
Myocardial Injury ◽  
Heart Diseases ◽  
Pressure Overload ◽  
Systemic Arterial Pressure ◽  
Control Group ◽  
Congenital Heart Diseases ◽  
Healthy Children ◽  
Early Management ◽  
And Control

Background.Children with congenital heart diseases (CHDs) may have a risk of developing myocardial injury caused by volume and pressure overload.Objective.To evaluate the incidence of myocardial injury in children with cyanotic and acyanotic CHDs using cTnI assay and to correlate it with different hemodynamic parameters.Methods.This study included 80 children with CHDs (40 acyanotic and 40 cyanotic) as well as 40 healthy children (control group). Serum cTnI levels were measured for patients and control. Pulmonary to systemic blood flow (Qp/Qs) and pulmonary to systemic arterial pressure (Pp/Ps) ratios were measured for children with CHDs during cardiac catheterization.Results.Sixty-four out of 80 patients with CHDs had myocardial injury as evidenced by increased cTnI. Serum cTnI was significantly higher in both cyanotic and acyanotic groups compared to control group (p<0.05). Serum cTnI level significantly correlated with oxygen saturation (SpO2), ejection fraction (EF), Qp/Qs, and Pp/Ps ratios.Conclusion.The incidence of myocardial injury was high in children with CHDs. The use of cTnI for follow-up of children with CHDs may help early detection of myocardial injury and help early management of these cases.

Cardiac aetiology

2018 ◽  
Author(s):  
Guillaume Turc ◽  
David Calvet ◽  
Jean-Louis Mas
Keyword(s):  
Myocardial Infarction ◽  
Young Adults ◽  
Ischaemic Stroke ◽  
Patent Foramen Ovale ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Recurrence Risk ◽  
Congenital Heart Diseases ◽  
Foramen Ovale ◽  
Valvular Heart Diseases

Cardiac aetiology accounts for approximately 20% of strokes in young adults. Although atrial fibrillation is a leading cause of stroke in the general population, it is uncommon in young adults. In such patients, more diverse causes of ischaemic stroke are observed, including valvular heart diseases, infective endocarditis, Libman–Sacks endocarditis, dilated cardiomyopathies, congenital heart diseases, myocardial infarction, and intracardiac tumours. Patent foramen ovale is commonly observed in young adults with ischaemic stroke, but this association may be incidental in a sizeable proportion of patients. Young adults who are the most likely to have a stroke-related patent foramen ovale are also those with the lowest recurrence risk.

Traffic Jam Response

2015 ◽  
Vol 77 (8) ◽  
pp. 632-636
Author(s):  
Robert M. Kao
Keyword(s):  
Heart Development ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Pulmonary Artery Stenosis ◽  
Congenital Heart Diseases ◽  
Genetic Aberrations ◽  
Traffic Jam ◽  
Morphological Complexity ◽  
Hands On ◽  
Students First

Congenital heart disease in newborns exhibits a spectrum of defects, one of which is the occlusion of the vascular conduits of the arteries. For students first learning about cardiovascular lesions, the tortuous path of blood vessels can be visually overwhelming to the untrained eye, and useful models are needed to help deconstruct the morphological complexity of heart chambers and vessel location during heart development and disease. Here, I present two hands-on activities to explore how pulmonary artery stenosis may have dire consequences, such as cardiac muscle cell hypertrophy. These activities will not only help students explore genetic aberrations associated with congenital heart diseases, but will also encourage them to think about how to develop molecular and cellular strategies that fix primary obstruction in other branched organs such as the gut, kidney, and pancreas.

scholarly journals The year 2018 in the European Heart Journal—Cardiovascular Imaging: Part II

2019 ◽  
Vol 20 (12) ◽  
pp. 1337-1344
Author(s):  
Bernard Cosyns ◽  
Kristina H Haugaa ◽  
Bernhard L Gerber ◽  
Alessia Gimelli ◽  
Erwan Donal ◽  
...  
Keyword(s):  
Heart Failure ◽  
Impact Factor ◽  
Myocardial Ischaemia ◽  
Congenital Heart ◽  
Myocardial Function ◽  
European Heart Journal ◽  
Heart Diseases ◽  
Cardiovascular Imaging ◽  
Congenital Heart Diseases ◽  
Valvular Heart Diseases

Abstract European Heart Journal - Cardiovascular Imaging was launched in 2012 as a multimodality cardiovascular imaging journal. It has gained an impressive impact factor during its first 5 years and is now established as one of the top cardiovascular journals and has become the most important cardiovascular imaging journal in Europe. The most important studies from 2018 will be highlighted in two reports. Part I of the review has focused on studies about myocardial function and risk prediction, myocardial ischaemia, and emerging techniques in cardiovascular imaging, while Part II will focus on cardiomyopathies, congenital heart diseases, valvular heart diseases, and heart failure.

scholarly journals Study on Maternal SNPs of MTHFR Gene and HCY Level Related to Congenital Heart Diseases

2020 ◽  
Author(s):  
Hui Shi ◽  
Shiwei Yang ◽  
Ning Lin ◽  
Peng Huang ◽  
Rongbin Yu ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Drug Exposure ◽  
Heart Diseases ◽  
Mthfr Gene ◽  
Control Group ◽  
Homozygous Mutation ◽  
Control Analysis ◽  
Congenital Heart Diseases ◽  
History Of ◽  
The Relationship

AbstractThe aim of this study is to evaluate the relationship between maternal single nucleotide polymorphisms (SNPs) of methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine (HCY) level and offspring congenital heart diseases (CHDs). 338 mothers with offspring CHDs as case group and 306 mothers of normal children as control group were recruited. Their pregnant histories were interviewed by questionnaire and the MTHFR rsl801133 and rsl801131 were genotyped. The case–control analysis was used to find out the relationship between maternal SNPs of MTHFR gene and offspring CHDs. And the plasma HCY concentration of the mothers of CHDs children was detected. This case–case study was intended to find out the relevance between maternal HCY level and SNPs of MTHFR gene. There were significant differences in the gender of children, occupation of mothers, family history with CHDs, history of abortion, history of adverse pregnancy, early pregnancy health, fetus during pregnancy, pesticide exposure and drug exposure in CHDs group and control group (P < 0.05). MTHFR rs1801133 was significantly associated with their offspring CHDs in mothers. The polymorphism of maternal MTHFR rs1801133 increased plasma HCY level, especially the homozygous mutation. Besides the environmental factors, our results suggested that the maternal MTHFR rs1801133 polymorphism might be a risk factor of their offspring CHDs, which may be due to the hyperhomocysteinemia by abnormal metabolism of HCY.

scholarly journals Assessment of Dental Status and Oral Health Status in Children with Congenital Heart Diseases

2019 ◽  
pp. 42-58
Author(s):  
Sreenita Chowdhury ◽  
Binita Srivastava ◽  
Siddhartha Pujari ◽  
Nidhi Gupta ◽  
Rashi Singh ◽  
...  
Keyword(s):  
Rural Areas ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Dental Health ◽  
Oral Health Status ◽  
Permanent Dentition ◽  
Control Group ◽  
Congenital Heart Diseases ◽  
Healthy Children ◽  
Cardiac Group

Purpose: This study aims to identify the dental caries, decayed, missing, and filled teeth index (dmft/DMFT) scores amongst children with cyanotic, and acyanotic congenital heart diseases (CHD), compare with healthy controls and identify the risk factors for poor dental health. Methods: Between January 2016 and June 2017, 236 children aged 2 to 15 years (mean±SD=7.61±3.88 yrs, median 7 yrs) with CHD and 951 healthy children aged 2 to 15 years (mean±SD=8.83±7.34 yrs, median 9 yrs) were evaluated. Results: Children with CHD had more caries in their primary and permanent dentition (mean dmft: 2.42±3.82, cardiac group vs. 2.32±6.68, control group; p<0·05; mean DMFT: 2.15±3.38, cardiac group vs. 1.27±1.89, control group; p=0.002). The DMFT scores for children with CHD were higher in the rural areas. Children frequently consuming biscuits, confectionary and sugared milk had higher dmft±SD scores. The possibility of caries in permanent dentition was more in children with cyanotic CHD compared to acyanotic. Caries in primary dentition showed positive correlation with age. Conclusions: CHD is associated with poorer dental health in children. Close cooperation between pediatric cardiologists and pediatric dentists is warranted to raise awareness, prevent and institute early treatment for dental ailments.

scholarly journals The Clinical and Functional Description of the Cardiovascular System in Children with Diseases of the Circulatory System

2019 ◽  
pp. 48-52
Author(s):  
N. A. Skuratova ◽  
A. V. Mikityuk ◽  
V. V. Fedorova
Keyword(s):  
Cardiovascular System ◽  
Autonomic Dysfunction ◽  
Heart Development ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Circulatory System ◽  
Holter Monitoring ◽  
Congenital Heart Diseases ◽  
Conduction Disturbances ◽  
Minor Anomalies

Objective: to give the clinical and functional characteristics of the cardiovascular system in children with diseases of the circulatory system. Material and мethods. The study involved 188 children aged 8-16 with different cardiovascular diseases (CVD) examined at the Cardiology Ward of Gomel Regional Children`s Hospital. Depending on the profile of their diseases, the children were divided into five main groups: group 1 - children with minor anomalies of heart development, group 2 - children with congenital heart diseases, group 3 - children with rhythm disorders, group 4 - children with autonomic dysfunction, group 5 - children with arterial hypertension. Along with the clinical examination the children were performed an electrocardiogram (ECG) and underwent Holter monitoring (HM). Results. The polymorphism of complaints was typical of the children of all the groups, according to the ECG data, conduction disturbances were the most common in the children of the first and second groups, and excitability disorders were typical of the children of the third group. Normal ECG was most often recorded in the children of the fourth and fifth groups. By the НM data arrhythmia (II Lown class and higher) was most frequently detected in the children of the first and third groups, arrhythmia of V class prevailed in the second group of the children. Conclusion. The cardiologic examination found that the children with CVD had various complaints and different arrhythmia classes, while the ECG of the majority of the children with autonomic dysfunction and hypertension detected mild arrhythmias, which is indicative of prognostically favorable disease outcomes. Clinically significant arrhythmias were revealed most frequently in the children with minor anomalies of heart development, cardiac rhythm disorders and congenital heart diseases.

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