Kinetics of excess (above background) copper and zinc in Hyalella azteca and their relationship to chronic toxicity

1995 ◽  
Vol 52 (4) ◽  
pp. 864-874 ◽  
Author(s):  
U. Borgmann ◽  
W. P. Norwood
Keyword(s):  
Hyalella Azteca ◽  
Dry Weight ◽  
Whole Body ◽  
Continuous Exposure ◽  
Simple Diffusion ◽  
Copper And Zinc ◽  
Zinc Concentrations ◽  
Simple Diffusion Model ◽  
Control Body ◽  
The Impact

One-week-long metal uptake experiments with Hyalella azteca are potentially a powerful tool for rapidly assessing the impact of copper or zinc in contaminated water samples. Copper and zinc concentrations in whole body Hyalella are independent of body size for both control and metal-exposed amphipods. Uptake rates are rapid for both metals, but copper concentrations in Hyalella during continuous exposure peak at about 1 week, then gradually decline back towards control levels at an apparent rate of 0.039 d−1. Hyalella can, therefore, control body copper concentrations during exposure to elevated copper, but only gradually and after long exposure periods. Depuration rates for copper and zinc (0.16 and 0.68 d−1 respectively) are approximately five times slower than the apparent depuration rates during uptake, assuming a simple diffusion model. Uptake at increasing water concentrations results in saturation for both metals with maximum accumulations of 3.6 μmol/g dry weight above background. A mathematical model including saturation kinetics satisfactorily explains the more rapid approach to equilibrium observed during uptake than during depuration. Significant chronic mortality occurred at metal exposures that resulted in predicted accumulations of 1.8 μmol Cu/g or 1.3 μmol Zn/g above background after 1 week of uptake.

EDTA toxicity and background concentrations of copper and zinc in Hyalella azteca

1995 ◽  
Vol 52 (4) ◽  
pp. 875-881 ◽  
Author(s):  
U. Borgmann ◽  
W. P. Norwood
Keyword(s):  
Culture Media ◽  
Hyalella Azteca ◽  
Dry Weight ◽  
Complexing Agent ◽  
Copper Uptake ◽  
Background Concentrations ◽  
Copper And Zinc ◽  
Metal Levels ◽  
Zinc Concentrations ◽  
Zinc Levels

The effect of the strong metal-complexing agent EDTA on survival, growth, and copper and zinc concentrations in Hyalella azteca was studied to determine if metal concentrations in control amphipods represent minimum physiological levels. Exposure to EDTA concentrations of up to 560 μM for 1 week did not reduce metal levels (mean background = 1.2 μmol Cu/g and 1.0 μmol Zn/g dry weight), indicating that background metals are firmly bound to Hyalella. Chronic (4 week) exposure to EDTA resulted in increased mortality and reduced growth rates, both of which could be partially ameliorated by adding zinc to culture media. This implies that EDTA toxicity results, in part, from zinc deficiency. In spite of this, however, zinc concentrations in Hyalella were not reduced in amphipods raised in the presence of high EDTA, implying that the observed background zinc levels represent minimum physiological levels. Copper additions to media were ineffective at reducing EDTA toxicity. Nevertheless, control concentrations are probably close to minimum physiological levels for copper as well, because high EDTA did not appreciably reduce copper in Hyalella in chronic tests, in spite of its ability to impair copper uptake from water at moderate water concentrations.

scholarly journals Canine Liver Iron, Copper, and Zinc Concentrations and Association with Histologic Lesions

2002 ◽  
Vol 14 (5) ◽  
pp. 396-402 ◽  
Author(s):  
Patricia C. Schultheiss ◽  
Cathy L. Bedwell ◽  
Dwayne W. Hamar ◽  
Martin J. Fettman
Keyword(s):  
Iron Concentration ◽  
Dry Weight ◽  
Liver Iron ◽  
Inflammatory Lesions ◽  
Liver Copper ◽  
Iron Copper ◽  
Copper And Zinc ◽  
Zinc Concentrations ◽  
High Liver ◽  
Iron Concentrations

Concentrations of iron, copper, and zinc were measured in livers of 95 dogs that were suspected of having liver disease. Iron concentrations ranged from 177 to 7,680 ppm (dry weight basis); 54 dogs had iron concentrations greater than the normal concentration of 1,200 ppm. Iron stores were present in Kupffer cells and macrophages but not hepatocytes. The dogs did not have lesions of hemochromatosis. Dogs with high liver iron tended to have high liver copper and inflammatory lesions. High liver copper concentrations usually were associated with hepatocellular necrosis and fibrosis. High liver zinc was found in only 5 animals and was accompanied by histologic inflammatory lesions in one. In humans, increased iron concentration in the liver exacerbates liver damage caused by a variety of insults, and the same may be true for dogs.

Assessing the impact of corrosion control measures on tap drinking water of the Greater Vancouver Regional District

2005 ◽  
Vol 32 (5) ◽  
pp. 948-956 ◽  
Author(s):  
Gillian Knox ◽  
Don Mavinic ◽  
Jim Atwater ◽  
Doug MacQuarrie
Keyword(s):  
Drinking Water ◽  
Cold Water ◽  
Temperature Fluctuations ◽  
Control Measures ◽  
Seasonal Temperature ◽  
Source Water ◽  
Corrosion Control ◽  
Copper And Zinc ◽  
Zinc Concentrations ◽  
The Impact

A study on the quality of water distributed within the Greater Vancouver Regional District (GVRD) was carried out to evaluate the effectiveness of previously implemented corrosion controls. In addition, the effect of temperature fluctuations was investigated to determine if it influenced the efficacy of the control measures. The GVRD was divided into four distribution areas. The Capilano water had no corrosion control treatment. Seymour, Coquitlam, and Newton waters were treated with soda ash, resulting in a pH of 6.8, 6.9, and 8.1, respectively. Standing cold water and running hot and cold water samples were collected from the four zones and analyzed for lead, copper, and zinc concentrations. The source water did not influence the amount of lead at the tap. The source water did influence the amount of copper and zinc at the tap. The highest copper and zinc concentrations were found in the water with the lowest pH (Capilano) and the lowest concentrations in the water with the highest pH (Newton). Seasonal temperature fluctuations of distributed GVRD water did not affect the metal concentrations in the water.Key words: corrosion control, GVRD drinking water, copper, lead, zinc, pH adjustment.

scholarly journals Impact of Green Stormwater Infrastructure Age and Type on Water Quality

2021 ◽  
Vol 13 (18) ◽  
pp. 10484
Author(s):  
Cara Poor ◽  
Troy Membrere ◽  
Jared Miyasato
Keyword(s):  
Soil Water ◽  
Copper And Zinc ◽  
Zinc Concentrations ◽  
Green Stormwater Infrastructure ◽  
Urban Stormwater Runoff ◽  
Rain Events ◽  
Almost All ◽  
The University ◽  
Soil Mix ◽  
The Impact

Green stormwater infrastructure (GSI) has become increasingly common to mitigate urban stormwater runoff. However, there is limited research on the impact of age and type of GSI. This study evaluated nutrient and metals concentrations in the soil water of five different GSI systems located at the University of Portland in Portland, Oregon. The GSI systems included a bioretention curb extension (part of Portland’s Green Street project), a bioretention basin, a bioretention planter, an infiltration basin, and a bioswale ranging in age from 2 to 11 years. Samples were taken from each system during rain events over a 10-month period and analyzed for copper (Cu), zinc (Zn), phosphate (PO43−), and total phosphorus (TP). Copper and zinc concentrations were found to be impacted by GSI age, with lower concentrations in older systems. The same trend was not found with PO43− and TP, where almost all GSI systems had soil water concentrations much higher than average stormwater concentrations. Age likely played a role in phosphorus soil water concentrations, but other factors such as sources had a stronger influence. Phosphorus is likely coming from the compost in the soil mix in addition to other sources in runoff. This study shows that GSI systems can be effective for copper and zinc, but changes to the soil mix design are needed to reduce high levels of PO43− and TP in soil water.

COPPER AND ZINC INDUCED CHANGES IN SOYBEAN (Glycine max (L.) Merr.)

1970 ◽  
pp. 09
Author(s):  
K. SANKAR GANESH ◽  
P. SUNDARAMOORTHY
Keyword(s):  
Heavy Metals ◽  
Glycine Max ◽  
Aquatic Environment ◽  
Morphological Traits ◽  
Industrial Activities ◽  
Copper And Zinc ◽  
Glycine Max L ◽  
Zinc Concentrations ◽  
Induced Changes

Heavy metals are one of the most important pollutants released to the aquatic environment by the various industrial activities. The use of these wastewater for irrigation results accumulation of heavy metals in soil and plants. So, the present investigation deals with the various concentrations (0, 5, 10, 25, 50, 100, 200 and 300 mg/l) of copper and zinc on germination studies of soybean. The different concentrations of copper and zinc were used for germination studies. The seedlings were allowed to grow upto seven days. The studied morphological traits increased at 5 mg/l concentration and these parameters are gradually decreased with the increase of copper and zinc concentrations.

The yield of perennial grass stands on drained organic soils of Steppe

2016 ◽  
Vol 1 (90) ◽  
pp. 92-97
Author(s):  
I.T. Slusar ◽  
V.A. Serbenyuk ◽  
A.N. Gera ◽  
A.P. Solyanik ◽  
A.A. Tarasenko
Keyword(s):  
Zinc Sulphate ◽  
Foliar Application ◽  
Perennial Grass ◽  
Mineral Fertilizer ◽  
Dry Weight ◽  
Research Area ◽  
Organic Soils ◽  
Growth Promoters ◽  
Cobalt Sulfate ◽  
The Impact

Research on the impact of the introduction of micro fertilizers and growth promoters on a background of mineral fertilizer and without N90R45К120 spent on old peat in shallow carbonate floodplain r.Supiy, Yahotyn Kyiv region. Power peat horizon about 60-70 cm, 7,4-7,6 pH of the aqueous extract, stupas schedule 56-60%, density 0,49-0,52 assembly soil, total nitrogen content (%) - 1.9; gross forms of phosphorus - 0,4, potassium 0.2, 20% lime. In experiments studying biological rehoplant, radustym, Biolan, emistim, Jets, humisol, plantafol, radyfarm and micronutrients: copper, boric acid, manganese sulphate, zinc sulphate, potassium humates. Treatment drugs conducted in the spring by spraying mixtures. Space research area of 60 m2, three-time repetition. It is established that the use of growth stimulants and micronutrients in the background N90R45К120 provided the highest yield mixtures of years, against making BIOLan - 9.9 t / ha Radyfarmu - 9.6 t / ha Radostymu 9.3 t / ha dry weight. In areas for making other preparations were intermediate yield growth rates - 0.5 - 2.0 t / ha dry weight. Also good gains herbage yields obtained by making all kinds of micronutrients and growth stimulants in the background without making makrodobryv which was within 5.3 - 6.9 t / ha to control without fertilization - 4.5 t / ha dry weight. In deep peat copper fertilizer (25 kg / ha of copper sulphate or 5 kg / ha pirytnoho cinders) in all zones should be making every 3-4 years, and zinc, cobalt and molybdenum advisable to make time for the growing season, spring, by foliar application in such numbers: ammonium molibdenovokyslyy - 0.3 kg / ha; cobalt sulfate - 3 kg / ha zinc sulphate 0.5 kg / ha or placers these salts should be mixed with major fertilizer.

A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway

2021 ◽  
pp. 1-10
Author(s):  
Varvara Kanti ◽  
Lia Puder ◽  
Irina Jahnke ◽  
Philipp Maximilian Krabusch ◽  
Jan Kottner ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Skin Pigmentation ◽  
Gene Mutations ◽  
Continuous Treatment ◽  
Whole Body ◽  
Hair Color ◽  
Phase 2 ◽  
Loss Of Function ◽  
The Impact ◽  
Over Time

<b><i>Background and Objectives:</i></b> Gene mutations within the leptin-melanocortin signaling pathway lead to severe early-onset obesity. Recently, a phase 2 trial evaluated new pharmacological treatment options with the MC4R agonist <i>setmelanotide</i> in patients with mutations in the genes encoding proopiomelanocortin (POMC) and leptin receptor (LEPR). During treatment with <i>setmelanotide,</i> changes in skin pigmentation were observed, probably due to off-target effects on the closely related melanocortin 1 receptor (MC1R). Here, we describe in detail the findings of dermatological examinations and measurements of skin pigmentation during this treatment over time and discuss the impact of these changes on patient safety. <b><i>Methods:</i></b> In an investigator-initiated, phase 2, open-label pilot study, 2 patients with loss-of-function POMC gene mutations and 3 patients with loss-of-function variants in LEPR were treated with the MC4R agonist <i>setmelanotide</i>. Dermatological examination, dermoscopy, whole body photographic documentation, and spectrophotometric measurements were performed at screening visit and approximately every 3 months during the course of the study. <b><i>Results:</i></b> We report the results of a maximum treatment duration of 46 months. Skin pigmentation increased in all treated patients, as confirmed by spectrophotometry. During continuous treatment, the current results indicate that elevated tanning intensity levels may stabilize over time. Lips and nevi also darkened. In red-haired study participants, hair color changed to brown after initiation of <i>setmelanotide</i> treatment. <b><i>Discussion:</i></b> <i>Setmelanotide</i> treatment leads to skin tanning and occasionally hair color darkening in both POMC- and LEPR-deficient patients. No malignant skin changes were observed in the patients of this study. However, the results highlight the importance of regular skin examinations before and during MC4R agonist treatment.

scholarly journals The Impact of Nordic Walking on Bone Properties in Postmenopausal Women with Pre-Diabetes and Non-Alcohol Fatty Liver Disease

2021 ◽  
Vol 18 (14) ◽  
pp. 7570
Author(s):  
Xiaming Du ◽  
Chao Zhang ◽  
Xiangqi Zhang ◽  
Zhen Qi ◽  
Sulin Cheng ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Postmenopausal Women ◽  
Fatty Liver Disease ◽  
Whole Body ◽  
Nordic Walking ◽  
Significant Group ◽  
Time Interaction ◽  
Bone Properties ◽  
The Impact

This study investigated the impact of Nordic walking on bone properties in postmenopausal women with pre-diabetes and non-alcohol fatty liver disease (NAFLD). A total of 63 eligible women randomly participated in the Nordic walking training (AEx, n = 33), or maintained their daily lifestyle (Con, n = 30) during intervention. Bone mineral content (BMC) and density (BMD) of whole body (WB), total femur (TF), femoral neck (FN), and lumbar spine (L2-4) were assessed by dual-energy X-ray absorptiometry. Serum osteocalcin, pentosidine, receptor activator of nuclear factor kappa-B ligand (RANKL) levels were analyzed by ELISA assay. After an 8.6-month intervention, the AEx group maintained their BMCTF, BMDTF, BMCL2−4, and BMDL2−4, and increased their BMCFN (p = 0.016), while the Con group decreased their BMCTF (p = 0.008), BMDTF (p = 0.001), and BMDL2−4 (p = 0.002). However, no significant group × time interaction was observed, except for BMDL2−4 (p = 0.013). Decreased pentosidine was correlated with increased BMCWB(r = −0.352, p = 0.019). The intervention has no significant effect on osteocalcin and RANKL. Changing of bone mass was associated with changing of pentosidine, but not with osteocalcin and RANKL. Our results suggest that Nordic walking is effective in preventing bone loss among postmenopausal women with pre-diabetes and NAFLD.

scholarly journals The Effect of Repeated Whole-Body Cryotherapy on Sirt1 and Sirt3 Concentrations and Oxidative Status in Older and Young Men Performing Different Levels of Physical Activity

Antioxidants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 37
Author(s):  
Gabriela Wojciak ◽  
Jadwiga Szymura ◽  
Zbigniew Szygula ◽  
Joanna Gradek ◽  
Magdalena Wiecek
Keyword(s):  
Physical Activity ◽  
Young Men ◽  
Oxidative Status ◽  
Whole Body ◽  
Stress Index ◽  
Blood Levels ◽  
Long Distance ◽  
Antioxidant Defence ◽  
Whole Body Cryotherapy ◽  
The Impact

Background: The activity of antioxidant enzymes and sirtuins (Sirt) decreases along with age, which is counteracted by aerobic training. Sirtuins increase antioxidant defence. Whole-body cryotherapy (WBC) increases total antioxidant capacity (TAC) in young men. The aim of our study was to assess the impact of 24 WBC treatments on the blood concentration of selected sirtuins and the level of antioxidant defence as well as oxidative stress index of training and non-training men depending on age. Methods: The study involved 40 males. In each group, there were 10 non-training older and young men (60 NTR and 20 NTR), and 10 older and young long-distance runners (60 TR, 20 TR). During an 8-week period, participants underwent 24 WBC treatments (3 min −130 °C), which were performed three times a week (Monday, Wednesday, Friday). The concentrations of Sirt1, Sirt3, TAC, total oxidative status and the activity of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in the blood were determined before 1 WBC and after 1 WBC, 12 WBC and 24 WBC. Results: After 1 WBC, the activity of GPx and the concentration of Sirt1 and TAC in 60 TR and TAC in 60 NTR increased. After 12 WBC, the level of Sirt1 in 20 NTR and SOD in 20 TR increased. After 24 WBC, the level of Sirt1 increased in 60 TR and in 20 NTR, Sirt3 in 60 TR and SOD in 20 TR. Conclusions: Cryogenic temperatures increase blood levels of Sirt1 and Sirt3 and systemic antioxidant defence in men, but the effect is dependent on age, level of performed physical activity and the number of applied treatments.

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