scholarly journals The Effect of Repeated Whole-Body Cryotherapy on Sirt1 and Sirt3 Concentrations and Oxidative Status in Older and Young Men Performing Different Levels of Physical Activity

Antioxidants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 37
Author(s):  
Gabriela Wojciak ◽  
Jadwiga Szymura ◽  
Zbigniew Szygula ◽  
Joanna Gradek ◽  
Magdalena Wiecek
Keyword(s):  
Physical Activity ◽  
Young Men ◽  
Oxidative Status ◽  
Whole Body ◽  
Stress Index ◽  
Blood Levels ◽  
Long Distance ◽  
Antioxidant Defence ◽  
Whole Body Cryotherapy ◽  
The Impact

Background: The activity of antioxidant enzymes and sirtuins (Sirt) decreases along with age, which is counteracted by aerobic training. Sirtuins increase antioxidant defence. Whole-body cryotherapy (WBC) increases total antioxidant capacity (TAC) in young men. The aim of our study was to assess the impact of 24 WBC treatments on the blood concentration of selected sirtuins and the level of antioxidant defence as well as oxidative stress index of training and non-training men depending on age. Methods: The study involved 40 males. In each group, there were 10 non-training older and young men (60 NTR and 20 NTR), and 10 older and young long-distance runners (60 TR, 20 TR). During an 8-week period, participants underwent 24 WBC treatments (3 min −130 °C), which were performed three times a week (Monday, Wednesday, Friday). The concentrations of Sirt1, Sirt3, TAC, total oxidative status and the activity of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in the blood were determined before 1 WBC and after 1 WBC, 12 WBC and 24 WBC. Results: After 1 WBC, the activity of GPx and the concentration of Sirt1 and TAC in 60 TR and TAC in 60 NTR increased. After 12 WBC, the level of Sirt1 in 20 NTR and SOD in 20 TR increased. After 24 WBC, the level of Sirt1 increased in 60 TR and in 20 NTR, Sirt3 in 60 TR and SOD in 20 TR. Conclusions: Cryogenic temperatures increase blood levels of Sirt1 and Sirt3 and systemic antioxidant defence in men, but the effect is dependent on age, level of performed physical activity and the number of applied treatments.

scholarly journals Decreased Lipid Profile and Oxidative Stress in Healthy Subjects Who Underwent Whole-Body Cryotherapy in Closed Cryochamber with Subsequent Kinesiotherapy

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Agata Stanek ◽  
Ewa Romuk ◽  
Tomasz Wielkoszyński ◽  
Stanisław Bartuś ◽  
Grzegorz Cieślar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Healthy Subjects ◽  
Whole Body ◽  
Stress Index ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Whole Body Cryotherapy ◽  
The Impact ◽  
And Oxidative Stress

Objective. The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) and subsequent kinesiotherapy on oxidative stress and lipid profile when performed in a closed cryochamber on healthy subjects. Material and Methods. The effect of ten WBC procedures lasting 3 minutes a day followed by a 60-minute session kinesiotherapy on oxidative stress and lipid profile in healthy subjects (WBC group, n=16) was investigated. The WBC group was compared to the kinesiotherapy only (KT; n=16) group. The routine parameters of oxidative stress (antioxidant enzymatic and nonenzymatic antioxidant status, lipid peroxidation products, total oxidative status (TOS), and oxidative stress index (OSI)) and lipid profile were estimated one day before the beginning and one day after the completion of the research program. Results. After treatment, in the WBC group, a significant decrease of oxidative stress markers (TOS and OSI) and a significant increase of total antioxidant capacity were observed. The activity of plasma SOD-Mn and erythrocyte total SOD increased significantly in the WBC group. In the KT group, the erythrocyte activity of total SOD, CAT, and GR decreased significantly after the treatment. The levels of T-Chol and LDL-Chol decreased significantly after treatment in both groups, but the observed decrease of these lipid parameters in the WBC group was higher in comparison to the KT group. The level of TG decreased significantly after treatment in the WBC group only. Conclusion. WBC performed in a closed cryochamber followed by kinesiotherapy improves lipid profile and decreases oxidative stress in healthy subjects.

scholarly journals Effect of Whole-Body Cryotherapy on Morphological, Rheological and Biochemical Indices of Blood in People with Multiple Sclerosis

2021 ◽  
Vol 10 (13) ◽  
pp. 2833
Author(s):  
Bartłomiej Ptaszek ◽  
Aneta Teległów ◽  
Justyna Adamiak ◽  
Jacek Głodzik ◽  
Szymon Podsiadło ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neurological Diseases ◽  
Venous Blood ◽  
Whole Body ◽  
Controlled Study ◽  
Control Group ◽  
Blood Indices ◽  
Rheological Indices ◽  
Whole Body Cryotherapy ◽  
The Impact

The aim of this study was to examine and assess the impact of a series of 20 whole-body cryotherapy (WBC) treatments on the biochemical and rheological indices of blood in people with multiple sclerosis. In this prospective controlled study, the experimental group consisted of 15 women aged 34–55 (mean age, 41.53 ± 6.98 years) with diagnosed multiple sclerosis who underwent a series of whole-body cryotherapy treatments. The first control group consisted of 20 women with diagnosed multiple sclerosis. This group had no intervention in the form of whole-body cryotherapy. The second control group consisted of 15 women aged 30–49 years (mean age, 38.47 ± 6.0 years) without neurological diseases and other chronic diseases who also underwent the whole-body cryotherapy treatment. For the analysis of the blood indices, venous blood was taken twice (first, on the day of initiation of whole-body cryotherapy treatments and, second, after a series of 20 cryotherapy treatments). The blood counts were determined using an ABX MICROS 60 hematological analyzer (USA). The LORCA analyzer (Laser–Optical Rotational Cell Analyzer, RR Mechatronics, the Netherlands) was used to study the aggregation and deformability of erythrocytes. The total protein serum measurement was performed using a Cobas 6000 analyzer, Roche and a Proteinogram-Minicap Sebia analyzer. Fibrinogen determinations were made using a Bio-Ksel, Chrom-7 camera. Statistically significant differences and changes after WBC in the levels of red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), elongation index, total extend of aggregation (AMP), and proteins (including fibrinogen) were observed. However, there was no significant effect of a series of 20 WBC treatments on changes in blood counts, rheology, and biochemistry in women with multiple sclerosis. Our results show that the use of WBC has a positive effect on the rheological properties of the blood of healthy women.

scholarly journals Decreased Oxidative Stress in Male Patients with Active Phase Ankylosing Spondylitis Who Underwent Whole-Body Cryotherapy in Closed Cryochamber

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Agata Stanek ◽  
Armand Cholewka ◽  
Tomasz Wielkoszyński ◽  
Ewa Romuk ◽  
Aleksander Sieroń
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Ankylosing Spondylitis ◽  
Antioxidant Status ◽  
Active Phase ◽  
Post Treatment ◽  
Whole Body ◽  
Male Patients ◽  
Whole Body Cryotherapy ◽  
The Impact

Objective. The aim of the study was to estimate the impact of whole body cryotherapy (WBC) on oxidative stress when performed in a closed cryochamber on patients with ankylosing spondylitis (AS). Material and methods. The effect of ten WBC procedures lasting 3 minutes a day with a subsequent 60-minute session kinesiotherapy on oxidative stress in male AS patients (WBC group n=16) was investigated. To assess the disease activity, the Bath Ankylosing Spondylitis Diseases Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) were calculated. The WBC group was compared to the kinesiotherapy only (KT; n=16) group. The routine parameters of oxidative stress (antioxidant enzymatic and nonenzymatic antioxidant status, lipid peroxidation products, total oxidative status (TOS), and oxidative stress index (OSI)) were estimated one day before the beginning and one day after the completion of the research program. Results. After the completion of the treatment in the WBC group, a significant decrease of oxidative stress markers (TOS and OSI) and a significant increase of total antioxidant status were observed. The erythrocyte activity of glutathione peroxidase, glutathione reductase decreased significantly in both groups, but the differences of activity of that enzymes prior to post treatment values (Δ) in the KT group were significantly higher as compared to the WBC group. The activity of erythrocyte catalase and plasma ZnCu isoenzyme of superoxide dismutase showed a decreased tendency; erythrocyte total superoxide dismutase activity showed an increased tendency in the WBC group after the completion of the treatment. The BASDAI and BASFI decreased significantly in both groups, but the differences of value indexes prior to post treatment (Δ) were significantly higher in the WBC than KT group. Conclusion. WBC performed in a closed cryochamber decreases oxidative stress and improves BASDAI and BASFI indexes in male patients during the active phase of ankylosing spondylitis.

scholarly journals Event-related potentials following exercise bouts of different intensity

2007 ◽  
Vol 60 (11-12) ◽  
pp. 531-535 ◽  
Author(s):  
Otto Barak ◽  
Vesna Ivetic ◽  
Danka Filipovic ◽  
Nada Naumovic ◽  
Damir Lukac ◽  
...  
Keyword(s):  
Physical Activity ◽  
Positive Impact ◽  
Event Related Potentials ◽  
Bicycle Ergometer ◽  
Whole Body ◽  
Functional Diagnostics ◽  
Ergometer Exercise ◽  
Related Potentials ◽  
The Impact ◽  
Bicycle Ergometer Exercise

Introduction. A number of articles on physical activity analyze the effects of acute bouts of physical exercise on the whole body. These experiments mainly include questionnaires and measurements of reaction time. The use of event-related potentials in laboratories for functional diagnostics is only of recent date. The aim of this experiment was to give insights into the impact of physical activity of different intensity on the amplitude and latency of P300 cognitive potentials. Material and methods. After recording cognitive event-related potentials in 17 young (21.6?1.07 yrs) healthy adults (at Fz and Cz), the participants underwent a controlled bicycle ergometer exercise. Each exercise lasted 10 minutes, with successive increase in the intensity to 60%, 75% and 90% of the maximum pulse rate and maintaining this level of intensity for six minutes. Immediately after each bout of exercise, event-related potentials were recorded. Results. The amplitude of the P300 wave, following exercise intensity at 75% of the maximum pulse (Pmax) (Fz 15.00?4.57; Cz 18.63?8.83 mV) was statistically higher (p<0.05) than the amplitude of the P300 at rest (Fz 11.21?4.15 mV; Cz 13.40?8.04 mV), at 60% (Fz 11.86?5.11 mV; Cz 14.54?8.06 mV) and at 90% of maximum pulse (Fz 13.26?4.73 mV; Cz 14.91?8.91 mV). There were no statistically significant differences (p>0.05) between amplitudes at 60% of Pmax and values obtained at rest and at 90% of Pmax. Also, no statistically significant differences were recorded (p>0.05) among the latencies of P300 recorded at rest (Fz 323.57?13.24 ms; Cz 323.57?13.24 ms) and at 60% of Pmax (Fz 321.14?22.38 ms; Cz 321.86?22.88 ms), at 75% of Pmax (Fz 321.50?16.67 ms; Cz 322.50?14.60 ms) and at 90% of Pmax (Fz 326.29?7.85 ms; Cz 325.43?7.63 ms). Discusssion and Conclusion. Physical activity has a positive impact on cognitive functions. At intermediate intensities, the amplitude of P300 increases, but at submaximal intensities it decreases to values obtained at rest. However, the latency of P300 did not show a statistically significant change after different intensities of exercise.

Evaluation of the Impact of the Whole-body Cryotherapy Treatment on the Functional Condition of the Knee Joints in Patients with Rheumatoid Arthritis

2021 ◽  
Vol 63 (2) ◽  
pp. 93-98
Author(s):  
Agnieszka Przedborska ◽  
Mateusz Szymczak ◽  
Małgorzata Kilon ◽  
Łukasz Kikowski ◽  
Jan Raczkowski
Keyword(s):  
Rheumatoid Arthritis ◽  
Muscle Strength ◽  
Range Of Motion ◽  
Functional State ◽  
Functional Condition ◽  
Knee Joints ◽  
Whole Body ◽  
Gait Function ◽  
Whole Body Cryotherapy ◽  
The Impact

Introduction: Rheumatoid arthritis (RA) is a chronic disease that leads to disability of patients. The use of the whole-body cryotherapy treatment for RA patients provides analgesic and anti-inflammatory effects and improves their efficiency. Aim: Assessment of the effect of the whole-body cryotherapy treatment on the functional state of knee joints for patients with RA. Material and Method: The study was conducted on a group of 30 RA patients, who underwent a series of 10 whole-body cryotherapy treatment. The effectiveness and efficiency of the applied therapy was assessed on the basis of: the VAS scale, the Laitinen scale, the assessment of the range of motion, muscle strength with the MicroFet dynamometer and the Up and Go test. Results: As a result of the applied whole-body cryotherapy treatment, a reduction in the intensity of pain, measured with the VAS scale and the Laitinen scale, and a reduction in the duration of morning stiffness by about 55% were found. There was an increase in the range of motion and muscle strength. The time needed to perform the Up and Go test was reduced by 17%. Conclusions: The whole-body cryotherapy treatment is an effective analgesic method of physiotherapy for patients with RA. It provides an improvement in the functional state, increases the range of motion, muscle strength and improves the gait function.

scholarly journals Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Agata Stanek ◽  
Armand Cholewka ◽  
Tomasz Wielkoszyński ◽  
Ewa Romuk ◽  
Aleksander Sieroń
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Cardiovascular Risk Factors ◽  
Whole Body ◽  
Markers Of Inflammation ◽  
Whole Body Cryotherapy ◽  
The Impact

Objective. The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) on cardiovascular risk factors in patients with ankylosing spondylitis (AS). Material and Methods. We investigated the effect of WBC with subsequent kinesiotherapy on markers of inflammation, oxidative stress, lipid profile, and atherosclerosis plaque in male AS patients (WBC group). To assess the disease activity, the BASDAI and BASFI were also calculated. The results from the WBC group were compared with results from the kinesiotherapy (KT) group. Results. The results showed that in the WBC group, the plasma hsCRP level decreased without change to the IL-6 level. The ICAM-1 level showed a decreasing tendency. The CER concentration, as well as the BASDAI and BASFI, decreased in both groups, but the index changes of disease activity were higher in the WBC than KT patients. Additionally, in the WBC group, we observed a decrease in oxidative stress markers, changes in the activity of some antioxidant enzymes and nonenzymatic antioxidant parameters. In both groups, the total cholesterol and LDL cholesterol, triglycerides, sCD40L, PAPP-A, and PLGF levels decreased, but the parameter changes were higher in the WBC group. Conclusion. WBC appears to be a useful method of atherosclerosis prevention in AS patients.

scholarly journals Effect of Whole-Body Cryotherapy on Antioxidant Systems in Experimental Rat Model

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Bronisława Skrzep-Poloczek ◽  
Ewa Romuk ◽  
Bernadeta Wiśnowiska ◽  
Aleksander J. Owczarek ◽  
Piotr Choręza ◽  
...  
Keyword(s):  
Study Groups ◽  
Oxidative Status ◽  
Whole Body ◽  
Antioxidant Systems ◽  
Transferase Activity ◽  
Glutathione S Transferase ◽  
Total Antioxidant ◽  
Total Oxidative Status ◽  
Experimental Rat Model ◽  
Whole Body Cryotherapy

Background. The purpose of this study was to verify the effect of whole-body cryotherapy (WBC) in rats on their antioxidant systems, lipid peroxidation products, and their total oxidative status at different exposure times and temperatures.Methods. Antioxidants in serum, plasma, liver, and erythrocytes were evaluated in two study groups following 1 min of exposure to −60°C and −90°C, for 5 and 10 consecutive days.Results. WBC increased the activity of superoxide dismutase, catalase in the group subjected to 5 and 10 days exposure, −60°C. The glutathione S-transferase activity increased in the groups subjected to 10 days WBC sessions. Total antioxidant capacity increased after 5 and 10 days of 1 min WBC, −60°C; a decrease was observed at −90°C. A decreased level of erythrocyte malondialdehyde concentration was observed at −60°C after 5 and 10 days of cryostimulation. An increased concentration was measured at −90°C after 10 days, and increase of erythrocyte malondialdehyde concentration after 5 days, −90°C.Conclusions. To the best of our knowledge, this is the first research showing the effect of WBC in rats at different exposure times and temperatures. The effect of cryotherapy on enzymatic and nonenzymatic antioxidant systems was observed in the serum of animals exposed to a temperature of −60°C in comparison to control.

scholarly journals Effect of whole-body cryotherapy on morphological, rheological, and biochemical blood indices in individuals with multiple sclerosis

2021 ◽  
Author(s):  
Bartłomiej Ptaszek ◽  
Aneta Teległów ◽  
Justyna Adamiak ◽  
Jacek Głodzik ◽  
Szymon Podsiadło ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Positive Impact ◽  
Erythrocyte Aggregation ◽  
Whole Body ◽  
Total Serum Protein ◽  
Total Serum ◽  
Control Group ◽  
Blood Indices ◽  
Whole Body Cryotherapy ◽  
The Impact

Abstract The study aim was to examine the impact of 20 whole-body cryotherapy sessions on biochemical and rheological blood indices in multiple sclerosis individuals. The study group involved 15 women (mean age: 41.53 ± 6.98 years) with diagnosed multiple sclerosis who underwent whole-body cryotherapy sessions. The first control group consisted of 20 women (mean age: 40.45 ± 4.77 years) with multiple sclerosis who received no cryotherapy intervention. The second control group comprised 15 women (mean age: 38.47 ± 6.0 years) without neurological diseases or other chronic conditions who participated in cryotherapy sessions. For blood indices analysis, venous blood was collected twice: on the day of cryotherapy commencement and after the 20 cryotherapy sessions. Blood counts were determined with a hematology analyzer. A laser-optical rotational cell analyzer served to investigate erythrocyte aggregation and deformability. Total serum protein was measured, and proteinogram and fibrinogen values were established. Statistically significant differences were observed in red blood cells, hemoglobin, hematocrit, elongation index, total extent of aggregation, proteins (including fibrinogen). There was no significant effect of the 20 cryotherapy sessions on morphological, rheological, or biochemical blood indices in women with multiple sclerosis. The intervention had a positive impact on the rheological blood properties of healthy women.

scholarly journals PO-228 Effects of Different Cryotherapy Models on Timing Sequence Recovery of Exercise Induced Muscle Damage in Middle and Long Distance Runners

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Chaoyi Qu ◽  
Minxiao Xu ◽  
Fei Qin ◽  
Yanan Dong ◽  
Zhongwei Wang ◽  
...  
Keyword(s):  
Exercise Performance ◽  
Performance Indicators ◽  
Water Immersion ◽  
The Other ◽  
Treadmill Running ◽  
Whole Body ◽  
Distance Runners ◽  
Long Distance ◽  
Biochemical Indicators ◽  
Whole Body Cryotherapy

Objective Exercise induced muscle damage (EIMD) is one common physiological phenomenon in competitive sports and mass sports. Water immersion recovery and whole body cryotherapy (cryostimulation) (WBC) has become one of the fast recovery methods adopted by high level athletes in the world. The aim of this study was to compare the water immersion recovery and WBC from timing sequential recovery on EIMD, subjective scales, biochemical indicators, exercise performance indicators. Methods Twelve middle and long distance runners from Beijing Sport University were recruited in this study (exercise performance is secondary level in China). All participants performed four models in four weeks which included rest control (CON), cold water immersion(CWI), contrast water therapy (CWT) and whole body cryotherapy (cryostimulation) (WBC) separated by one week. The subjects needed to complete the EIMD exercise program, includes two parts: the treadmill running and the jump step. The individual speed of treadmill running was based on the individual VO2max. running including 5 sets and total time is about 90 min. Every set consist of 6 min flat running, 6 min uphill running and 6 min downhill running. The speed of the treadmill was stable in different stages. The slope of the uphill running is（＋6,＋5,＋4,＋3,＋2）, and the slope of downhill running is (-8, -7, -6, -5, -4). The jump was performed 20 times separated by 30 s via special step ( height is 40 cm) . After the EIMD exercise program, the subjects were treated with different recovery methods immediately after exercise, 24 h, 48 h, 72 h after exercise, while CON group received no intervention. The CWI group was immerged in 15 °C cold water for 12min, and the CWT groups was immerged in 15°C cold water for 1min and 38°C hot water for 1min with 6 cycles. The whole body cryotherapy (cryostimulation) group was immerged in special chamber (-110—-140℃）for 3 min. The three interventions were immerged body to the position of shoulders. The indexes including subjective scales (VAS scale, RPE scale, Borg scale, WHO deep sleep scale, PQSI scale), biochemical indicators (creatine kinase, lactate dehydrogenase, myoglobin, interleukin-6, C reactive protein, SICAM-1), exercise performance indicators ( vertical jump height, grip, running distance). The indexes was collected in different periods (i.e. Before exercise, immediately after exercise,Post1h, Post 24h, Post 48h, Post 72h, Post 96h after exercise etc.). Results  (1) Subjective scales. From results of VAS scale, RPE scale, and Borg scale, the WBC had best recovery effects than the other three interventions (P<0.05).  The recovery effect of the CWI group was similar with the CON group. From results of WHO deep sleep scale and PQSI scale, the WBC group had better recovery effects than CON group (P<0.05). (2) Biochemical indicators. From results of CK, Mb and SICAM-1, the WBC group had better recovery effect than the other three groups (P<0.05). In the LDH, the WBC group had similar effects with the CWT group (P>0.05). From results of CRP and IL-6, the WBC group had better recovery effects than the other three groups (P<0.05).（3）Exercise performance indicators. From results of vertical jump, WBC had lower decrease than the other three groups (P<0.05).  From results of the grip, of the WBC and CWT groups have significant retentive effects than CON group (P<0.05), but there was no significant difference between CON and CWI groups (P>0.05). Conclusions (1)Through combine the treadmill running and the jump step exercise program,Can effectively lead to human body appear the EIMD. (2)WBC has positive effects on the subjective scale, biochemical indicators, exercise performance indicators associated with EIMD.For middle and long distance runners EIMD,compared with CWI CWT,WBC effect is better.(3) CWI and CWT has a positive effect on some subjective scales, biochemical indicators, and exercise performance indicators related to EIMD. However, the positive effect of CWI and CWT is lower than WBC in the extent of action and timing sequence. (4)For the middle and long distance runners EIMD timing sequence recovery effects,WBC have better effects,Followed by CWT , CWI  effect is not significant.

scholarly journals The influence of whole body cryotherapy on plasma concentration of melatonin and serotonin in patients with osteoarthrosis of the lumbar spine

2021 ◽  
Vol 13 (1) ◽  
pp. 55-61
Author(s):  
MARTA MARTA BARŁOWSKA-TRYBULEC ◽  
JOANNA SZKLARCZYK ◽  
JOLANTA JAWOREK
Keyword(s):  
Lumbar Spine ◽  
Study Groups ◽  
Whole Body ◽  
Functional Efficiency ◽  
Therapeutic Exercises ◽  
Group A ◽  
Group B ◽  
Whole Body Cryotherapy ◽  
The Impact ◽  
Plasma Serotonin

Background: ‪Osteoarthrosis (OA) is the most common disease affecting mankind. There are many physiotherapeutic methods of treating OA symptoms. One of them is whole body cryotherapy (WBCT). The aim of this study was to present the impact of WBCT combined with kinesiotherapy on functional efficiency and changes in plasma concentrations of serotonin and melatonin in patients with lumbar spine OA.. Material and methods: ‪60 patients underwent a series of WBCT combined with kinesiotherapy (group A). 60 patients underwent a series of kinesiotherapy alone (group B). Before and after the therapy patients were examined by Rolland Morris Disability Questionnaire (RMDQ), and blood samples were collected for laboratory assessment. Results: ‪Following therapy, the functional efficiency (RMDQ) improved by 33% in both study groups (p < 0.0001). After the therapy, both in the group of patients undergoing WBCT combined with exercises (group A, p = 0.032) and the cryotherapy alone (group B, p < 0.0001), the plasma melatonin concentration significantly increased. The rise of plasma serotonin concentrations was higher in group B as compared to group A, but in both study groups the increase in plasma serotonin was statistically significant (p < 0.0001).. Conclusions: ‪WBCT combined with therapeutic exercises as well as kinesiotherapy used alone resulted in an increase in melatonin and serotonin plasma levels and an improvement in functional efficiency in patients with lumbar spine OA.

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