scholarly journals Antinociceptive effects of gentiopicroside on neuropathic pain induced by chronic constriction injury in mice: a behavioral and electrophysiological study

2016 ◽  
Vol 94 (7) ◽  
pp. 769-778 ◽  
Author(s):  
Ning Liu ◽  
Yu-Xiang Li ◽  
Shuai-Shuai Gong ◽  
Juan Du ◽  
Gang Liu ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Electrophysiological Study ◽  
Compound Action Potential ◽  
Functional Index ◽  
Antinociceptive Effects ◽  
Conduction Velocities ◽  
Behavioral Parameters ◽  
Sciatic Functional Index ◽  
Compound Action

Gentiopicroside (Gent) is promising as an important protective secoiridoid compound against pain. The present study was designed to investigate whether administration of Gent would alleviate the expression of nociceptive behaviors and whether it would cause the relevant electrophysiological changes in a chronic constriction injury (CCI) model of neuropathic pain in mice. Gent was administered from the seventh day after surgery for 8 consecutive days. Behavioral parameters and sciatic functional index were assessed immediately before surgery and on days 7, 8, 10, 12, and 14 post-CCI, and electrophysiological activities of sciatic nerve were recorded immediately after the behavioral test on the last day. The present study has shown that administration of Gent (at a dose of 50 and 100 mg/kg) increased behavioral parameters from day 8 compared with the CCI-NS group. Electrophysiological data indicated that CCI caused a significant reduction in nerve conduction velocities in the sciatic nerves and the amplitudes of compound action potential, while Gent at a dose of 50 or 100 mg/kg caused a significant recovery of electrophysiological changes induced by CCI. Our data indicated that Gent has antinociceptive effects on neuropathic pain induced by CCI.

An Electrophysiological Study of the Posterior Abdominal Vagus Nerve in Man

1982 ◽  
Vol 63 (2) ◽  
pp. 169-173 ◽  
Author(s):  
P. L. R. Andrews ◽  
T. V. Taylor
Keyword(s):  
Action Potential ◽  
Vagus Nerve ◽  
Electrophysiological Study ◽  
Compound Action Potential ◽  
Conduction Velocities ◽  
C Fibre ◽  
Compound Action

1. The compound action potential was recorded in segments of posterior abdominal vagus removed from patients undergoing elective vagotomy and the conduction velocities of the major components were measured. 2. The conduction velocities ranged from 0·15 m/s to 3·9 m/s. The majority of compound potentials recorded had latencies appropriate to C fibre conduction.

scholarly journals Essential Oil of Croton zehntneri Prevents Conduction Alterations Produced by Diabetes Mellitus on Vagus Nerve

Plants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 893
Author(s):  
Kerly Shamyra Silva-Alves ◽  
Francisco Walber Ferreira-da-Silva ◽  
Andrelina Noronha Coelho-de-Souza ◽  
José Henrique Leal-Cardoso
Keyword(s):  
Diabetes Mellitus ◽  
Essential Oil ◽  
Diabetic Neuropathy ◽  
Vagus Nerve ◽  
Therapeutic Agent ◽  
Specific Treatment ◽  
Compound Action Potential ◽  
Unmyelinated Fibers ◽  
Conduction Velocities ◽  
Compound Action

Autonomic diabetic neuropathy (ADN) is a complication of diabetes mellitus (DM), to which there is no specific treatment. In this study, the efficacy of the essential oil of Croton zehntneri (EOCz) in preventing ADN was evaluated in the rat vagus nerve. For the two fastest conducting myelinated types of axons of the vagus nerve, the conduction velocities and rheobase decreased, whilst the duration of the components of the compound action potential of these fibers increased. EOCz completely prevented these DM-induced alterations of the vagus nerve. Unmyelinated fibers were not affected. In conclusion, this investigation demonstrated that EOCz is a potential therapeutic agent for the treatment of ADN.

scholarly journals Nauclea latifolia Smith (Rubiaceae) exerts antinociceptive effects in neuropathic pain induced by chronic constriction injury of the sciatic nerve

2014 ◽  
Vol 151 (1) ◽  
pp. 445-451 ◽  
Author(s):  
Germain Sotoing Taïwe ◽  
Elisabeth Ngo Bum ◽  
Emmanuel Talla ◽  
Théophile Dimo ◽  
Amadou Dawe ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Chronic Constriction Injury ◽  
Antinociceptive Effects ◽  
Nauclea Latifolia

Attenuating Effect of Portulaca oleracea Extract on Chronic Constriction Injury Induced Neuropathic Pain in Rats: An Evidence of Anti-oxidative and Anti-inflammatory Effects

2019 ◽  
Vol 18 (4) ◽  
pp. 342-349 ◽  
Author(s):  
Fatemeh Forouzanfar ◽  
Hossein Hosseinzadeh ◽  
Mohammad B. Khorrami ◽  
Samira Asgharzade ◽  
Hassan Rakhshandeh
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Portulaca Oleracea ◽  
Dependent Manner ◽  
Tnf Α ◽  
Antinociceptive Effects ◽  
Drug Treatments ◽  
Thiol Content ◽  
Anti Inflammatory ◽  
Dose Dependent

Background: Neuropathic pain responds poorly to drug treatments. The present study investigated the therapeutic effect of Portulaca oleracea, in chronic constriction injury (CCI)-induced neuropathic pain in rats. Objective & Methods: Neuropathic pain was performed by putting four loose ligatures around the sciatic nerve. CCI resulted in the development of heat hyperalgesia, mechanical allodynia and cold allodynia accompanied by an increase in the contents of TNF-α, IL1β, malondialdehyde, with a reduction in total thiol content. Results: Administration of Portulaca oleracea (100 and 200 mg/kg intraperitoneal) for 14 days in CCI rats significantly alleviated pain-related behaviors, oxidative damage and inflammatory cytokines in a dose-dependent manner. Conclusion: In conclusion, it is suggested that the antinociceptive effects of Portulaca oleracea might be due to antioxidant and anti-inflammatory properties.

scholarly journals Antinociceptive effects of matrine on neuropathic pain induced by chronic constriction injury

2013 ◽  
Vol 51 (7) ◽  
pp. 844-850 ◽  
Author(s):  
Wang Haiyan ◽  
Li Yuxiang ◽  
Dun Linglu ◽  
Xu Tingting ◽  
Hao Yinju ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Antinociceptive Effects

scholarly journals Effects of Various Antiepileptics Used to Alleviate Neuropathic Pain on Compound Action Potential in Frog Sciatic Nerves: Comparison with Those of Local Anesthetics

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Yuhei Uemura ◽  
Tsugumi Fujita ◽  
Sena Ohtsubo ◽  
Naomi Hirakawa ◽  
Yoshiro Sakaguchi ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nerve Conduction ◽  
Local Anesthetics ◽  
Compound Action Potential ◽  
Receptor Activation ◽  
Nerve Fibers ◽  
Receptor Inhibition ◽  
Compound Action Potentials ◽  
Frog Sciatic Nerve ◽  
Compound Action

Antiepileptics used for treating neuropathic pain have various actions including voltage-gated Na+and Ca2+channels, glutamate-receptor inhibition, andGABAA-receptor activation, while local anesthetics are also used to alleviate the pain. It has not been fully examined yet how nerve conduction inhibitions by local anesthetics differ in extent from those by antiepileptics. Fast-conducting compound action potentials (CAPs) were recorded from frog sciatic nerve fibers by using the air-gap method. Antiepileptics (lamotrigine and carbamazepine) concentration dependently reduced the peak amplitude of the CAP (IC50=0.44and 0.50 mM, resp.). Carbamazepine analog oxcarbazepine exhibited an inhibition smaller than that of carbamazepine. Antiepileptic phenytoin (0.1 mM) reduced CAP amplitude by 15%. On the other hand, other antiepileptics (gabapentin, sodium valproate, and topiramate) at 10 mM had no effect on CAPs. The CAPs were inhibited by local anesthetic levobupivacaine (IC50=0.23 mM). These results indicate that there is a difference in the extent of nerve conduction inhibition among antiepileptics and that some antiepileptics inhibit nerve conduction with an efficacy similar to that of levobupivacaine or to those of other local anesthetics (lidocaine, ropivacaine, and cocaine) as reported previously. This may serve to know a contribution of nerve conduction inhibition in the antinociception by antiepileptics.

The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury

2016 ◽  
Vol 77 (5) ◽  
pp. 217-226 ◽  
Author(s):  
Janette Nallely Corona-Ramos ◽  
Minarda De la O-Arciniega ◽  
Myrna Déciga-Campos ◽  
José Raúl Medina-López ◽  
Adriana Miriam Domínguez-Ramírez ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Antinociceptive Effects

scholarly journals Curcumin Diglutaric Acid, a Prodrug of Curcumin Reduces Pain Hypersensitivity in Chronic Constriction Injury of Sciatic Nerve Induced-Neuropathy in Mice

2020 ◽  
Vol 13 (9) ◽  
pp. 212
Author(s):  
Thanchanok Limcharoen ◽  
Peththa Wadu Dasuni Wasana ◽  
Hasriadi Hasriadi ◽  
Chawanphat Muangnoi ◽  
Opa Vajragupta ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Analgesic Effect ◽  
Water Solubility ◽  
Chronic Constriction Injury ◽  
Repeated Administration ◽  
Tnf Α ◽  
Antinociceptive Effects ◽  
Low Solubility

The drug treatment for neuropathic pain remains a challenge due to poor efficacy and patient satisfaction. Curcumin has been reported to alleviate neuropathic pain, but its clinical application is hindered by its low solubility and poor oral bioavailability. Curcumin diglutaric acid (CurDG) is a curcumin prodrug with improved water solubility and in vivo antinociceptive effects. In this study, we investigated the anti-inflammatory mechanisms underlying the analgesic effect of CurDG in the chronic constriction injury (CCI)-induced neuropathy mouse model. Repeated oral administration of CurDG at a low dose equivalent to 25 mg/kg/day produced a significant analgesic effect in this model, both anti-allodynic activity and anti-hyperalgesic activity appearing at day 3 and persisting until day 14 post-CCI surgery (p < 0.001) while having no significant effect on the motor performance. Moreover, the repeated administration of CurDG diminished the increased levels of the pro-inflammatory cytokines: TNF-α and IL-6 in the sciatic nerve and the spinal cord at the lowest tested dose (equimolar to 25 mg/kg curcumin). This study provided pre-clinical evidence to substantiate the potential of pursuing the development of CurDG as an analgesic agent for the treatment of neuropathic pain.

scholarly journals Bioassay-Guided Evaluation of Antinociceptive Effect ofN-Salicyloyltryptamine: A Behavioral and Electrophysiological Approach

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Lucindo J. Quintans-Júnior ◽  
Davi A. Silva ◽  
Jullyana S. Siqueira ◽  
Adriano A. S. Araújo ◽  
Rosana S. S. Barreto ◽  
...  
Keyword(s):  
Action Potential ◽  
Neuronal Excitability ◽  
Antinociceptive Effect ◽  
Compound Action Potential ◽  
Nerve Excitability ◽  
Gap Technique ◽  
Antinociceptive Effects ◽  
Sucrose Gap ◽  
Second Phases ◽  
Compound Action

We investigated the antinociceptive and nerve excitability effects of theN-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg (i.p.) were administered (i.p.). This effect was not antagonized by naloxone (1.5 mg/kg, i.p.). NST inhibited the licking response of the injected paw when 100 and 200 mg/kg were administered (i.p.) to mice in the first and second phases of the formalin test. Because the antinociceptive effects could be associated with neuronal excitability inhibition, we performed the single sucrose gap technique and showed that NST (3.57 mM) significantly reduced (29.2%) amplitude of the compound action potential (CAP) suggesting a sodium channel effect induced by NST. Our results demonstrated an antinociceptive activity of the NST that could be, at least in part, associated to the reduction of the action potential amplitude. NST might represent an important tool for pain management.

scholarly journals Investigation into the role of P2X3 /P2X2/3 receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study

2006 ◽  
Vol 148 (6) ◽  
pp. 845-852 ◽  
Author(s):  
Caroline J Sharp ◽  
Alison J Reeve ◽  
Sue D Collins ◽  
Jo C Martindale ◽  
Scott G Summerfield ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Electrophysiological Study
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