An Electrophysiological Study of the Posterior Abdominal Vagus Nerve in Man

1982 ◽  
Vol 63 (2) ◽  
pp. 169-173 ◽  
Author(s):  
P. L. R. Andrews ◽  
T. V. Taylor
Keyword(s):  
Action Potential ◽  
Vagus Nerve ◽  
Electrophysiological Study ◽  
Compound Action Potential ◽  
Conduction Velocities ◽  
C Fibre ◽  
Compound Action

1. The compound action potential was recorded in segments of posterior abdominal vagus removed from patients undergoing elective vagotomy and the conduction velocities of the major components were measured. 2. The conduction velocities ranged from 0·15 m/s to 3·9 m/s. The majority of compound potentials recorded had latencies appropriate to C fibre conduction.

scholarly journals Essential Oil of Croton zehntneri Prevents Conduction Alterations Produced by Diabetes Mellitus on Vagus Nerve

Plants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 893
Author(s):  
Kerly Shamyra Silva-Alves ◽  
Francisco Walber Ferreira-da-Silva ◽  
Andrelina Noronha Coelho-de-Souza ◽  
José Henrique Leal-Cardoso
Keyword(s):  
Diabetes Mellitus ◽  
Essential Oil ◽  
Diabetic Neuropathy ◽  
Vagus Nerve ◽  
Therapeutic Agent ◽  
Specific Treatment ◽  
Compound Action Potential ◽  
Unmyelinated Fibers ◽  
Conduction Velocities ◽  
Compound Action

Autonomic diabetic neuropathy (ADN) is a complication of diabetes mellitus (DM), to which there is no specific treatment. In this study, the efficacy of the essential oil of Croton zehntneri (EOCz) in preventing ADN was evaluated in the rat vagus nerve. For the two fastest conducting myelinated types of axons of the vagus nerve, the conduction velocities and rheobase decreased, whilst the duration of the components of the compound action potential of these fibers increased. EOCz completely prevented these DM-induced alterations of the vagus nerve. Unmyelinated fibers were not affected. In conclusion, this investigation demonstrated that EOCz is a potential therapeutic agent for the treatment of ADN.

scholarly journals Antinociceptive effects of gentiopicroside on neuropathic pain induced by chronic constriction injury in mice: a behavioral and electrophysiological study

2016 ◽  
Vol 94 (7) ◽  
pp. 769-778 ◽  
Author(s):  
Ning Liu ◽  
Yu-Xiang Li ◽  
Shuai-Shuai Gong ◽  
Juan Du ◽  
Gang Liu ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Electrophysiological Study ◽  
Compound Action Potential ◽  
Functional Index ◽  
Antinociceptive Effects ◽  
Conduction Velocities ◽  
Behavioral Parameters ◽  
Sciatic Functional Index ◽  
Compound Action

Gentiopicroside (Gent) is promising as an important protective secoiridoid compound against pain. The present study was designed to investigate whether administration of Gent would alleviate the expression of nociceptive behaviors and whether it would cause the relevant electrophysiological changes in a chronic constriction injury (CCI) model of neuropathic pain in mice. Gent was administered from the seventh day after surgery for 8 consecutive days. Behavioral parameters and sciatic functional index were assessed immediately before surgery and on days 7, 8, 10, 12, and 14 post-CCI, and electrophysiological activities of sciatic nerve were recorded immediately after the behavioral test on the last day. The present study has shown that administration of Gent (at a dose of 50 and 100 mg/kg) increased behavioral parameters from day 8 compared with the CCI-NS group. Electrophysiological data indicated that CCI caused a significant reduction in nerve conduction velocities in the sciatic nerves and the amplitudes of compound action potential, while Gent at a dose of 50 or 100 mg/kg caused a significant recovery of electrophysiological changes induced by CCI. Our data indicated that Gent has antinociceptive effects on neuropathic pain induced by CCI.

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