scholarly journals Comparison of the rapid plasma reagin card test and other screening tests for treponemal disease in patients attending a venereal disease clinic.

1973 ◽  
Vol 49 (4) ◽  
pp. 342-345
Author(s):  
G Scrimgeour ◽  
P Rodin
Keyword(s):  
Venereal Disease ◽  
Screening Tests ◽  
Rapid Plasma Reagin ◽  
Disease Clinic ◽  
Treponemal Disease ◽  
Card Test

scholarly journals Evaluation of reagin screen, a new serological test for syphilis

1976 ◽  
Vol 4 (2) ◽  
pp. 145-150
Author(s):  
J D Dyckman ◽  
R D Wende ◽  
D Gantenbein ◽  
R P Williams
Keyword(s):  
Research Laboratory ◽  
Serological Test ◽  
Venereal Disease ◽  
The Other ◽  
Screening Tests ◽  
Venereal Disease Research Laboratory ◽  
Rapid Plasma Reagin ◽  
Disease Research ◽  
Antibody Absorption

A total of 1,020 serum and plasma specimens were tested using the Venereal Disease Research Laboratory (VDRL), Rapid Plasma Reagin (RPR) card, Reagin Screen (RST) and Fluorescent Treponemal Antibody-Absorption (FTA-ABS) tests. In 257 normal patients, all screening tests were nonreactive; the FTA-ABS test was reactive for one patient. In 588 patients with treated and untreated syphilis, the RST results were 91.7% in agreement with the VDRL and RPR results. In 175 patients with diseases that cause biological false reactions, the RST was 94% in agreement with the other screening tests. The titer of the RST was within one dilution of the corresponding VDRL titer in 91.7% of the 360 speciments tested and within one dilution of the RPR titer in 96.9% of 358 specimens quantitated by both tests.

scholarly journals Syphla-Chek: a qualitative study

1977 ◽  
Vol 5 (6) ◽  
pp. 593-595
Author(s):  
P E Dziuk ◽  
D A Black ◽  
B L Therrell
Keyword(s):  
Venereal Disease ◽  
Health Resources ◽  
Qualitative Evaluation ◽  
Rapid Plasma Reagin ◽  
Testing Procedures ◽  
Department Of Health ◽  
Antibody Absorption ◽  
Texas Department ◽  
Slide Test ◽  
Card Test

A qualitative evaluation of the newly marketed Syphla-Chek Test (Hyland, Div. of Travenol Laboratories, Inc., Costa Mesa, Calif.), a macroscopically read, nontreponemal card test, was undertaken in order to further evaluate the validity of this procedure as an aid in the diagnosis of syphilis. A total of 1,074 randomly selected sera submitted to the Texas Department of Health Resources for routine analysis, for confirmational analysis, and as a result of problems in analysis, were examined using the Venereal Disease Research Laboratory (VDRL) slide test, the Rapid Plasma Reagin (circle) Card Test (RPRCT), Syphla-Chek Test, and the fluorescent treponemal antibody absorption (FTA-ABS) test. Comparison of the reagin testing procedures studied versus the FTA-ABS procedure led to the following order of agreement with FTA-ABS reactive results: Syphla-Chek, 88.8%; RPRCT, 87.1%; and VDRL, 83.2%. Agreement with FTA-ABS nonreactive results was in order: RPRCT, 86.7%; Syphla-Chek, 79.6%; and VDRL, 78.7%. The relatively few minor procedural problems encountered with the Syphla-Chek Test during this study are also discussed.

scholarly journals Efektivitas Pemeriksaan Serologis Sifilis

e-CliniC ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Tirsa Baguna ◽  
Nurdjannah J. Niode ◽  
Herry E. J. Pandaleke
Keyword(s):  
Literature Review ◽  
Research Laboratory ◽  
Venereal Disease ◽  
Treponema Pallidum ◽  
Screening Tests ◽  
Venereal Disease Research Laboratory ◽  
Rapid Plasma Reagin ◽  
Serological Tests ◽  
Disease Research ◽  
Haemagglutination Assay

Abstract: High prevalence of syphilis can be reduced by doing screening. Tests used for screening and diagnosis of syphilis are serological tests of syphilis consisting of nontreponemal tests and treponemal tests. Nontreponemal tests consist of Rapid Plasma Reagin (RPR) and Venereal Disease Research Laboratory (VDRL) meanwhile Treponemal tests consist of Treponema Pallidum Haemagglutination Assay (TPHA) and Treponema Pallidum Rapid (TP Rapid). This study was aimed to determine the effectiveness of syphilis serological tests. This was a literature review study using the keywords namely serology OR serological OR serologic AND syphilis in PubMed and ClinicalKey. The literatures were written in English and/or Indonesian, published in the last 10 years (2011-2020), and can be accessed in full text. The results obtained 25 literatures. High sensitivity was found in RPR of 9.1%-100%, VDRL of 44.4% -100%, and TP Rapid of 50.0%-100%. High specificity was found in TPHA of 99.7% and TP Rapid of 85.3% -100%. In conclusion, effective syphilis screening is performed with RPR and VDRL, while effective syphilis diagnostic is performed with TP Rapid and TPHA.Keywords: syphilis, serology tests, effectiveness of tests  Abstrak: Prevalensi kasus sifilis yang tinggi dapat diturunkan dengan adanya skrining. Pemeriksaan yang digunakan untuk skrining dan diagnosis sifilis ialah pemeriksaan serologis sifilis, terdiri atas pemeriksaan serologis non spesifik treponema dan pemeriksaan serologis spesifik treponema. Pemeriksaan serologis non spesifik treponema antara lain Rapid Plasma Reagin (RPR) dan Venereal Disease Research Laboratory (VDRL). Pemeriksaan serologis spesifik treponema antara lain Treponema Pallidum Haemagglutination Assay (TPHA) dan Treponema Pallidum Rapid (TP Rapid). Penelitian ini bertujuan untuk mengetahui efektivitas pemeriksaan serologis sifilis. Jenis penelitian ialah literature review menggunakan kata kunci serology OR serological OR serologic AND syphilis di PubMed dan ClinicalKey. Literatur yang digunakan memiliki bahasa Inggris dan/atau bahasa Indonesia, terbitan 10 tahun terakhir (2011-2020), dan dapat diakses teks lengkap. Sensitivitas tinggi ditemukan pada RPR sebesar 9,1%-100%, VDRL sebesar 44,4%-100%, dan TP Rapid sebesar 50,0%-100%. Spesifisitas tinggi ditemukan pada TPHA sebesar 99,7% dan TP Rapid sebesar 85,3%-100%. Simpulan penelitian ini ialah skrining sifilis efektif dilakukan dengan RPR dan VDRL, sedangkan diagnostik sifilis efektif dilakukan dengan TP Rapid dan TPHA.Kata kunci: sifilis, pmeriksaan serologis, efektivitas pemeriksaan

scholarly journals Canadian Public Health Laboratory Network laboratory Guidelines for the Use of Serological Tests (excluding point-of-care tests) for the Diagnosis of Syphilis in Canada

2015 ◽  
Vol 26 (supplement a) ◽  
pp. 6A-12A ◽  
Author(s):  
Paul N Levett ◽  
Kevin Fonseca ◽  
Raymond SW Tsang ◽  
Kamran Kadkhoda ◽  
Bouchra Serhir ◽  
...  
Keyword(s):  
Research Laboratory ◽  
Laboratory Tests ◽  
Venereal Disease ◽  
Screening Tests ◽  
Current Status ◽  
Venereal Disease Research Laboratory ◽  
Rapid Plasma Reagin ◽  
Serological Tests ◽  
Syphilis Infection ◽  
Disease Research

Syphilis, caused by the bacteriumTreponema pallidumsubsp.pallidum, is an infection recognized since antiquity. It was first reported at the end of the 15th century in Europe. Infections may be sexually transmitted as well as spread from an infected mother to her fetus or through blood transfusions. The laboratory diagnosis of syphilis infection is complex. Because this organism cannot be cultured, serology is used as the principal diagnostic method. Some of the issues related to serological diagnoses are that antibodies take time to appear after infection, and serology screening tests require several secondary confirmatory tests that can produce complex results needing interpretation by experts in the field. Traditionally, syphilis screening was performed using either rapid plasma reagin or Venereal Disease Research Laboratory tests, and confirmed by treponemal tests such as MHA-TP, TPPA or FTA-Abs. Currently, that trend is reversed, ie, most of the laboratories in Canada now screen for syphilis using treponemal enzyme immunoassays and confirm the status of infection using rapid plasma reagin or Venereal Disease Research Laboratory tests; this approach is often referred to as the reverse algorithm. This chapter reviews guidelines for specimen types and sample collection, treponemal and non-treponemal tests utilized in Canada, the current status of serological tests for syphilis in Canada, the complexity of serological diagnosis of syphilis infection and serological testing algorithms. Both traditional and reverse sequence algorithms are recommended and the algorithm used should be based on a combination of local disease epidemiology, test volumes, performance of the proposed assays and available resources.

scholarly journals False-positive reactions in the rapid plasma reagin-card, fluorescent treponemal antibody-absorbed, and hemagglutination treponemal syphilis serology tests

1979 ◽  
Vol 9 (3) ◽  
pp. 369-372
Author(s):  
C R Peter ◽  
M A Thompson ◽  
D L Wilson
Keyword(s):  
False Positive ◽  
Research Laboratory ◽  
Venereal Disease ◽  
Venereal Disease Research Laboratory ◽  
Rapid Plasma Reagin ◽  
Disease Research ◽  
False Positive Reactions ◽  
Normal Individuals ◽  
Syphilis Serology ◽  
Card Test

Sera from 628 nonsyphilitic individuals were tested with the Rapid Plasma Reagin-Card, Fluorescent Treponemal Antibody-Absorbed, and Hemagglutination Treponemal Test for Syphilis tests to ascertain the comparative specificity of these tests. Many sera were also tested with the quantitative Venereal Disease Research Laboratory test. Sera included in the study were from both normal individuals and patients with a variety of illnesses and conditions. The Hemagglutination Treponemal Test for Syphilis gave the lowest overall percentage of false-positive reactions (1.6%), followed by the Fluorescent Treponemal Antibody-Absorbed test (3.3%) and the Rapid Plasma Reagin-Card test (10.8%).

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