scholarly journals Intensive statin therapy in acute coronary syndromes and stable coronary heart disease: a comparative meta-analysis of randomised controlled trials

Heart ◽  
2007 ◽  
Vol 93 (8) ◽  
pp. 914-921 ◽  
Author(s):  
J. Afilalo ◽  
A. A Majdan ◽  
M. J Eisenberg
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Acute Coronary Syndromes ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Stable Coronary Heart Disease ◽  
Coronary Syndromes ◽  
Randomised Controlled ◽  
Intensive Statin Therapy

scholarly journals The effects of almond consumption on fasting blood lipid levels: a systematic review and meta-analysis of randomised controlled trials

2016 ◽  
Vol 5 ◽  
Author(s):  
Kathy Musa-Veloso ◽  
Lina Paulionis ◽  
Theresa Poon ◽  
Han Youl Lee
Keyword(s):  
Systematic Review ◽  
Heart Disease ◽  
Randomised Controlled Trials ◽  
Large Scale ◽  
Meta Analysis ◽  
Blood Lipid ◽  
Controlled Trials ◽  
Lipid Levels ◽  
Randomised Controlled ◽  
Blood Lipid Levels

AbstractA systematic review and meta-analysis of randomised controlled trials was undertaken to determine the effects of almond consumption on blood lipid levels, namely total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), TAG and the ratios of TC:HDL-C and LDL-C:HDL-C. Following a comprehensive search of the scientific literature, a total of eighteen relevant publications and twenty-seven almond-control datasets were identified. Across the studies, the mean differences in the effect for each blood lipid parameter (i.e. the control-adjusted values) were pooled in a meta-analysis using a random-effects model. It was determined that TC, LDL-C and TAG were significantly reduced by −0·153 mmol/l (P < 0·001), −0·124 mmol/l (P = 0·001) and −0·067 mmol/l (P = 0·042), respectively, and that HDL-C was not affected (−0·017 mmol/l; P = 0·207). These results are aligned with data from prospective observational studies and a recent large-scale intervention study in which it was demonstrated that the consumption of nuts reduces the risk of heart disease. The consumption of nuts as part of a healthy diet should be encouraged to help in the maintenance of healthy blood lipid levels and to reduce the risk of heart disease.

scholarly journals Colchicine and Cardiovascular Outcomes: a Critical Appraisal of Recent Studies

2021 ◽  
Vol 23 (7) ◽  
Author(s):  
Maciej Banach ◽  
Peter E. Penson
Keyword(s):  
Acute Coronary Syndromes ◽  
Cardiovascular Events ◽  
Randomised Controlled Trials ◽  
Gastrointestinal Symptoms ◽  
Controlled Trials ◽  
Atherosclerotic Cardiovascular Disease ◽  
All Cause Mortality ◽  
Coronary Syndromes ◽  
Randomised Controlled

Abstract Purpose of Review Recent studies have demonstrated an important role for inflammation in the pathogenesis of atherosclerotic cardiovascular disease. Several studies have investigated the efficacy of colchicine (a widely used and safe anti-inflammatory drug) in patients with atherosclerosis. This review explains the rationale for the use of colchicine in this setting and critically appraises recent outcome trials. Recent Findings Two large randomised-controlled trials LoDoCo2 (included patients with chronic coronary syndromes) and COLCOT (acute coronary syndromes) have demonstrated reductions in atherosclerotic cardiovascular events, but not mortality. A smaller study (COPS) found no beneficial effect of colchicine but was probably underpowered. Summary Colchicine is effective at reducing cardiovascular events in chronic and acute coronary syndromes, although reductions in all-cause mortality have not been demonstrated during the period of follow-up in trials to date. Mild gastrointestinal symptoms are the most commonly reported adverse effects, although in well-designed randomised controlled trials these are relatively uncommon.

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