scholarly journals Percutaneous transluminal coronary angioplasty versus medical treatment for non-acute coronary heart disease: meta-analysis of randomised controlled trials

BMJ ◽  
2000 ◽  
Vol 321 (7253) ◽  
pp. 73-77 ◽  
Author(s):  
H. C Bucher
2021 ◽  
Vol 17 (2) ◽  
pp. 55-62
Author(s):  
O.A. Loskutov ◽  
O.M. Druzhyna ◽  
G.I. Kovtun ◽  
A.V. Khokhlov ◽  
O.M. Postupalsky ◽  
...  

Background. Extracorporeal membrane oxygenation has become an effective method in the treatment of adults and children with severe cardiac and pulmonary dysfunction resistant to conventional therapy. The aim of this article was to summarize an experience of extracorporeal membrane oxygenation usage for cardiac dysfunction, which develops in patients with coronary heart disease du-ring percutaneous transluminal coronary angioplasty. Materials and methods. The study comprised a retrospective, single-center analysis of 23 patients with coronary heart disease (19 men and 4 women, average age — 65.7 ± 12.3 years), who undertook the extracorporeal membrane oxygenation technique during percutaneous transluminal coronary angioplasty. Results. Thirteen (56.52 %) patients died directly in the hospital, or 30 days after a discharge. Independent predictors of fatal outcomes were: diabetes mellitus (OR = 17.58; 95% CI = 6.47–47.48; p = 0.00125), chronic renal failure (OR = 20.81; 95% CI = 5.95–72.21; p = 0.00014), damage to the right coronary artery (OR = 25.51; 95% CI = 8.27–79.12; p = 0.00013). For deceased patients, the “no-reflow” phenomenon was indicated in a larger portion of cases (23.1 % in the group of deceased versus 10 % in the group of survivors). A routine connection to extracorporeal membrane oxygenation before the occurrence of cardiac events was significantly more often used in the group of survived patients (90 % of cases) compared with the deceased (p = 0.0000001). Conclusions. Diabetes mellitus, chronic renal failure, and damage to the right co-ronary artery were independent predictors of mortality during percutaneous transluminal coronary angioplasty in patients with coronary heart disease. The routine use of extracorporeal membrane oxyge-nation in high-risk patients with percutaneous transluminal coronary angioplasty was a positive prognostic factor of patient survival.


2016 ◽  
Vol 5 ◽  
Author(s):  
Kathy Musa-Veloso ◽  
Lina Paulionis ◽  
Theresa Poon ◽  
Han Youl Lee

AbstractA systematic review and meta-analysis of randomised controlled trials was undertaken to determine the effects of almond consumption on blood lipid levels, namely total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), TAG and the ratios of TC:HDL-C and LDL-C:HDL-C. Following a comprehensive search of the scientific literature, a total of eighteen relevant publications and twenty-seven almond-control datasets were identified. Across the studies, the mean differences in the effect for each blood lipid parameter (i.e. the control-adjusted values) were pooled in a meta-analysis using a random-effects model. It was determined that TC, LDL-C and TAG were significantly reduced by −0·153 mmol/l (P < 0·001), −0·124 mmol/l (P = 0·001) and −0·067 mmol/l (P = 0·042), respectively, and that HDL-C was not affected (−0·017 mmol/l; P = 0·207). These results are aligned with data from prospective observational studies and a recent large-scale intervention study in which it was demonstrated that the consumption of nuts reduces the risk of heart disease. The consumption of nuts as part of a healthy diet should be encouraged to help in the maintenance of healthy blood lipid levels and to reduce the risk of heart disease.


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