Newcastle head and neck cadaver dissection course

BMJ ◽  
2011 ◽  
pp. d6995
Author(s):  
Naveed Kara
Keyword(s):  
Head And Neck ◽  
Cadaver Dissection ◽  
Dissection Course

The effect of simulation‐based education before a cadaver dissection course

2021 ◽  
Author(s):  
Tomiko Yakura ◽  
Naoyuki Hatayama ◽  
Chikako Kawahara ◽  
Yusuke Ohmichi ◽  
Mika Ohmichi ◽  
...  
Keyword(s):  
Cadaver Dissection ◽  
Simulation Based ◽  
Dissection Course

Australian training for contemporary airway management of obstructive sleep apnoea in ENT surgery: current status and future recommendations

2014 ◽  
Vol 129 (S1) ◽  
pp. S8-S15 ◽  
Author(s):  
S Mackay ◽  
S Holmes ◽  
A Jones
Keyword(s):  
Head And Neck ◽  
Obstructive Sleep Apnoea ◽  
Neck Surgery ◽  
Sleep Apnoea ◽  
Head And Neck Surgery ◽  
Current Status ◽  
Cadaver Dissection ◽  
Australian Society ◽  
Sleep Surgery ◽  
Obstructive Sleep

AbstractBackground:The identification and treatment of adult obstructive sleep apnoea and other sleep-related breathing issues demands nuanced clinical judgement to determine if surgery is appropriate and which surgery should be performed. No study to date has evaluated the sleep medicine curriculum from the perspective of the Australian ENT surgical trainee, or addressed potential strategies for improving levels of surgical skill and knowledge in this field.Methods:A cross-sectional survey was used to assess knowledge of sleep surgery in trainees enlisted with the Australian Society of Otolaryngology Head and Neck Surgery. After a cadaver dissection workshop on the latest reconstructive surgical techniques in adult OSA, a second survey was used to assess changes in the likelihood of applying techniques.Results:Overall, trainee confidence, knowledge and exposure to sleep-disordered breathing cases averaged below 50 per cent. The cadaver dissection workshop achieved consistent improvements in all areas assessed.Conclusion:Low confidence and lack of exposure to sleep surgery cases for ENT trainees supports a broadening of the Australian Society of Otolaryngology Head and Neck Surgery curriculum. This paper outlines possible ways to improve this situation.

London head and neck dissection course

BMJ ◽  
2012 ◽  
pp. e4222
Author(s):  
Nabeela Ahmed ◽  
Waseem Ahmed
Keyword(s):  
Head And Neck ◽  
Neck Dissection ◽  
Dissection Course

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

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