scholarly journals Lipids and inflammation: serial measurements of the lipid profile of blood donors who later developed rheumatoid arthritis

2006 ◽  
Vol 66 (2) ◽  
pp. 184-188 ◽  
Author(s):  
V P van Halm ◽  
M M J Nielen ◽  
M T Nurmohamed ◽  
D van Schaardenburg ◽  
H W Reesink ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Lipid Profile ◽  
Blood Donors ◽  
Serial Measurements

scholarly journals Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors

2004 ◽  
Vol 50 (2) ◽  
pp. 380-386 ◽  
Author(s):  
Markus M. J. Nielen ◽  
Dirkjan van Schaardenburg ◽  
Henk W. Reesink ◽  
Rob J. van de Stadt ◽  
Irene E. van der Horst-Bruinsma ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Blood Donors ◽  
Serial Measurements

scholarly journals AB0008 THE IMPACT OF STAT4 RS7574865, IL6 RS1800795, IL6R RS2228145 AND RS4845618 ON RHEUMATOID ARTHRITIS SUSCEPTIBILITY IN BELARUSIAN POPULATION

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1307.1-1308
Author(s):  
E. Siniauskaya ◽  
T. Kuzhir ◽  
V. Yagur ◽  
R. Goncharova
Keyword(s):  
Rheumatoid Arthritis ◽  
Blood Donors ◽  
Genetic Model ◽  
Online Tool ◽  
Genotype Frequencies ◽  
Systemic Disorder ◽  
Autoimmune Pathogenesis ◽  
The Impact ◽  
Arthritis Susceptibility

Background:Rheumatoid arthritis (RA) is a chronic systemic disorder of the connective tissue of still unknown aetiology and complex autoimmune pathogenesis that primarily affects small joints. HLA alleles provide for 11-37% of the RA heritability, suggesting the substantial role of the non-HLA loci in genetic predisposition to RA. Among non-HLA loci,IL6, IL6RandSTAT4genes attract attention, however, the data concerning their influence on RA risk are somewhat contradictory.Objectives:The aim of the study was to analyze the involvement of four SNPs (STAT4rs7574865,IL6rs1800795,IL6Rrs2228145 and rs4845618) in RA susceptibility.Methods:187 patients diagnosed with RA (mean age 58.2 ± 11.9), and 380 healthy blood donors (mean age 37.18 ± 10.69 years) were included into the study. DNA extraction from peripheral blood samples was performed using the phenol-chloroform method. SNPs were genotyped using the real-time PCR with fluorescent probes. The allele and genotype frequencies were compared using the χ2 test. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using the VassarStats online tool.Results:Utilizing recessive genetic model we found an association between TT genotype ofSTAT4rs7574865 (OR = 2.362; 95%CI [1.0378 – 5.376], p = 0.038) and RA. ForIL6rs1800795, it was found that CC genotype had significantly higher frequency among patients with rheumatoid arthritis as compared to that in controls (OR = 1.52; 95%CI [1.02 – 2.27], p = 0.0456). No associations ofIL6Rrs2228145 and rs4845618 SNPs with risk of RA were found in the total group of patients vs. controls. It was also shown thatIL6rs1800795 CC genotype frequency was significantly higher among the patients with RF-negative status (p = 0.0019).Conclusion:Thus, we provide evidence for association of theSTAT4rs7574865 andIL6rs1800795 variants with risk of RA in the Belarusian population, some features of interplay being revealed between gene polymorphisms analyzed and RA antibody status. Abovementioned SNPs may contribute to RA genetic susceptibility in the Belarusian population.Disclosure of Interests:None declared

scholarly journals Insights in the Role of Lipids, Oxidative Stress and Inflammation in Rheumatoid Arthritis Unveiled by New Trends in Lipidomic Investigations

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 45
Author(s):  
Helena Beatriz Ferreira ◽  
Tânia Melo ◽  
Artur Paiva ◽  
Maria do Rosário Domingues
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Lipid Profile ◽  
Inflammatory Responses ◽  
Molecular Level ◽  
Lipid Hydroperoxides ◽  
Lipid Species ◽  
Inflammatory Autoimmune Disease

Rheumatoid arthritis (RA) is a highly debilitating chronic inflammatory autoimmune disease most prevalent in women. The true etiology of this disease is complex, multifactorial, and is yet to be completely elucidated. However, oxidative stress and lipid peroxidation are associated with the development and pathogenesis of RA. In this case, oxidative damage biomarkers have been found to be significantly higher in RA patients, associated with the oxidation of biomolecules and the stimulation of inflammatory responses. Lipid peroxidation is one of the major consequences of oxidative stress, with the formation of deleterious lipid hydroperoxides and electrophilic reactive lipid species. Additionally, changes in the lipoprotein profile seem to be common in RA, contributing to cardiovascular diseases and a chronic inflammatory environment. Nevertheless, changes in the lipid profile at a molecular level in RA are still poorly understood. Therefore, the goal of this review was to gather all the information regarding lipid alterations in RA analyzed by mass spectrometry. Studies on the variation of lipid profile in RA using lipidomics showed that fatty acid and phospholipid metabolisms, especially in phosphatidylcholine and phosphatidylethanolamine, are affected in this disease. These promising results could lead to the discovery of new diagnostic lipid biomarkers for early diagnosis of RA and targets for personalized medicine.

FRI0068 LIPID PROFILE AND BONE MINERAL DENSITY IN PATIENTS WITH RHEUMATOID ARTHRITIS: IS THERE AN ADDED RISK OF OSTEOPOROSIS?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 610.1-611
Author(s):  
B. Touil ◽  
H. Azzouzi ◽  
O. Lamkhanat ◽  
F. Chennouf ◽  
I. Linda
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Linear Regression ◽  
Femoral Neck ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Mineral Density ◽  
High Tc ◽  
High Concentrations

Background:Bone is a target in many inflammatory rheumatic diseases such as rheumatoid arthritis (RA). It has been supposed that an atherogenic lipid profile could be associated with lower bone mineral density (BMD) and vertebral fractures (VF).Objectives:We aimed to evaluate the relationship between the lipid profile, BMD and the presence of VF in RA patients.Methods:A cross sectional study was conducted in a population of 169 established RA. In each subject we evaluated the body mass index (BMI), tobacco use, alcohol consumption, presence of diabetes and high blood pression, lipid profile (total cholesterol (TC), High density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LDLc), triglycerides (TG), and VF. RA characteristics were also assessed (disease duration, disease activity score (DAS), auto antibodies, corticosteroid intake, and secondary sjogren’s syndrome). BMD was measured by dual energy X-ray absorptiometry (DXA) in lumbar spine and femoral neck. Logistic and linear regression were performed with SPSS 20, both BMD and VF were assessed as dependent variables.Results:The mean age was 55.5±11.9 years, with a female predominance (152 women). The average BMI was 26.79 ± 5.36. We had 24.3 % of hypertensive patients and 16.6 % of diabetics. The average lipid concentrations were 4.39±1 mmol/L for TC, 1.293±0.36 mmol/L for HDLc, 2.74±0.80 mmol/L for LDLc and 1.25±0.62 mmol/L for TG. At the linear regression there was no correlation between plasma lipid concentrations and BMD, whether at the lumbar spine or the femoral neck. However we found a significant correlation between VF and high TC concentrations (p=0.043, OR: 2.864, 95% IC [1.036-7.922]). At the multivariate regression, high TC levels were still associated with VF, adjusted in BMI, age and the duration of corticosteroid use (p=0.006, OR: 6.07, 95% CI[1.69- 21.77]). The same finding was observed between high concentrations of HDLc and the prevalence of VF adjusted in the same variables (p=0.006, OR: 197.01, 95% CI [4.64-8363.51]).Conclusion:Although there was no relation between lipid plasma levels and BMD in our population. There was a significant association between high concentrations of TC, HDLc and the prevalence of VF.Disclosure of Interests:None declared

A2.18 Induction and characterisation of the dominant IL-10 producing B cell subset in healthy blood donors and rheumatoid arthritis patients

2016 ◽  
Vol 75 (Suppl 1) ◽  
pp. A22.2-A22
Author(s):  
ZS Bankó ◽  
J Pozsgay ◽  
M Tóth ◽  
T Gáti ◽  
G Nagy ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
B Cell ◽  
Blood Donors ◽  
Cell Subset

scholarly journals Potential Mechanisms Leading to the Abnormal Lipid Profile in Patients With Rheumatoid Arthritis Versus Healthy Volunteers and Reversal by Tofacitinib

2015 ◽  
Vol 67 (3) ◽  
pp. 616-625 ◽  
Author(s):  
Christina Charles-Schoeman ◽  
Roy Fleischmann ◽  
Jean Davignon ◽  
Howard Schwartz ◽  
Scott M. Turner ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Healthy Volunteers ◽  
Lipid Profile

Study the Associated of Rheumatoid Arthritis with Anemia and Lipid Profile Changes in the Men and Women Patients in the Holy City of Karbala

2018 ◽  
Vol 02 (07) ◽  
pp. 130-134
Author(s):  
Abeer Cheaid Yousif Al-Fatlawi ◽  
Zainab Salman Mahdi ◽  
Alaa Qasim Radhi ◽  
Zainab Kased Saeed ◽  
Zahraa Abdulhussien
Keyword(s):  
Rheumatoid Arthritis ◽  
Lipid Profile ◽  
Women Patients ◽  
Men And Women ◽  
Profile Changes ◽  
Holy City

Association between serum aminotransferase enzymes–lipid profile ratio and spontaneous HCV clearance in blood donors

2016 ◽  
Vol 11 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Ashraf A Tabll ◽  
Marwa A Kodous ◽  
Ayman T Abbas ◽  
Mohamed M Omran ◽  
Elsherbeny H Elsayed
Keyword(s):  
Lipid Profile ◽  
Blood Donors ◽  
Serum Aminotransferase ◽  
Spontaneous Hcv Clearance

Therapeutic impact of statins on the lipid profile and cardiovascular risk of patients with rheumatoid arthritis: Systematic literature review and meta-analysis

2019 ◽  
Vol 26 (1) ◽  
pp. 40-47
Author(s):  
Óscar Mauricio Muñoz ◽  
Óscar Andrés Reyna Carrasco ◽  
Sandra Milena Castelblanco ◽  
Ángel Alberto García ◽  
Daniel Gerardo Fernández-Avila
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Risk ◽  
Literature Review ◽  
Lipid Profile ◽  
Systematic Literature Review ◽  
Meta Analysis ◽  
Therapeutic Impact
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