Preparation of N-dimethylaminomethylene derivatives - A new method of a selective substitution of nucleoside amino groups

1967 ◽  
Vol 32 (9) ◽  
pp. 3159-3168 ◽  
Author(s):  
J. Žemlička ◽  
A. Holý
Keyword(s):  
New Method ◽  
Amino Groups ◽  
Selective Substitution

scholarly journals A new method for the study of glutaraldehyde-induced crosslinking properties in proteins with special reference to the reaction with amino groups.

1978 ◽  
Vol 26 (5) ◽  
pp. 412-414 ◽  
Author(s):  
S O Molin ◽  
H Nygren ◽  
L Dolonius
Keyword(s):  
Special Reference ◽  
High Reliability ◽  
New Method ◽  
Second Step ◽  
Amino Groups ◽  
Molar Excess ◽  
Low Protein ◽  
Modified Proteins

A new method for the study of glutaraldehyde reactions with proteins is presented. Glutaraldehyde-reacted protein is in a first step isolated and then in a second step reacted with aminohexyl groups bound to Sepharose particles. This reaction is linear at low protein concentrations and proceeds rapidly when proteins are reacted with 100-fold and 1000-fold molar excess of glutaraldehyde. This method enables the study of glutaraldehyde-induced crosslinking properties of the modified proteins as an isolated property with high reliability.

scholarly journals PEROXIDASE-LABELED ANTIBODY A NEW METHOD OF CONJUGATION

1974 ◽  
Vol 22 (12) ◽  
pp. 1084-1091 ◽  
Author(s):  
PAUL K. NAKANE ◽  
AKIRA KAWAOI
Keyword(s):  
Horseradish Peroxidase ◽  
Free Amino ◽  
Sodium Periodate ◽  
Enzymatic Activities ◽  
Carbohydrate Moiety ◽  
New Method ◽  
Amino Groups ◽  
Aldehyde Groups

A new method of conjugating horseradish peroxidase with proteins was developed. The carbohydrate moiety of fluorodinitrobenzene-blocked peroxidase was oxidized with sodium periodate to form aldehyde groups. The peroxidase-aldehyde was then bound to free amino groups of proteins unidirectionally at high efficiencies. Peroxidase-labeled immunoglobulin retained its immunologic as well as enzymatic activities.

A new method of quaternizing amines and its use in amino acid and peptide chemistry

1976 ◽  
Vol 54 (20) ◽  
pp. 3310-3311 ◽  
Author(s):  
Francis C. M. Chen ◽  
N. Leo Benoiton
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Methyl Iodide ◽  
New Method ◽  
Hydroxyl Groups ◽  
Amino Groups ◽  
Small Peptides ◽  
Peptide Chemistry ◽  
Selective Reagent ◽  
Derivatives Of

Methyl iodide and potassium bicarbonate in methanol is presented as a mild, efficient, and selective reagent for the quaternization of amino groups. It does not attack hydroxyl groups. Its use with amino acids, derivatives of lysine, and small peptides is described.

Copper-catalyzed substitution of allylic carbonates with diboron: A new approach to allylboronate synthesis

2008 ◽  
Vol 80 (5) ◽  
pp. 1039-1045 ◽  
Author(s):  
Hajime Ito ◽  
Shinichiro Ito ◽  
Yusuke Sasaki ◽  
Kou Matsuura ◽  
Masaya Sawamura
Keyword(s):  
Optically Active ◽  
New Method ◽  
Efficient Synthesis ◽  
Chirality Transfer ◽  
New Approach ◽  
Highly Efficient ◽  
Selective Substitution

Copper-catalyzed γ-selective substitution of allylic carbonates with diboron provides a new method for the efficient synthesis of allylboronates. Optically active α-chiral allylboronates were synthesized through the reaction of chiral allylic carbonates with bis(pinacolato)diboron in the presence of achiral Cu(I)-catalyst with highly efficient chirality transfer. Additionally, in the presence of a chiral Cu(I) catalyst, optically active α-chiral allylboronates were obtained with >90 % ee through the reaction of prochiral substrates with the diboron.

Sign in / Sign up

Export Citation Format

Share Document