On the mechanism of dehydration of secondary alcohols over alumina catalyst. III. Dehydration of substituted 1-phenylethanols

1967 ◽  
Vol 32 (6) ◽  
pp. 2320-2326 ◽  
Author(s):  
M. Kraus ◽  
K. Kochloefl
Keyword(s):  
Secondary Alcohols ◽  
Alumina Catalyst ◽  
Mechanism Of Dehydration ◽  
Substituted 1

4-Substituted 1-(1-(2-(arylthio)-5-halogenophenyl)ethyl)piperazines; Synthesis and biological screening

1987 ◽  
Vol 52 (4) ◽  
pp. 1062-1072 ◽  
Author(s):  
Vladimír Valenta ◽  
Jiří Holubek ◽  
Miroslav Protiva
Keyword(s):  
Sodium Borohydride ◽  
Thionyl Chloride ◽  
Helminth Species ◽  
Secondary Alcohols ◽  
Substitution Reactions ◽  
Biological Screening ◽  
Substituted 1

Reactions of 2,5-dichloroacetophenone and 2,5-dibromoacetophenone with a series of thiophenols gave the 2-(arylthio)-5-halogenoacetophenones VII and VIII which were reduced with sodium borohydride in ethanol to the secondary alcohols IX and X. Treatment with thionyl chloride afforded the chloro compounds XI and XII which were transformed by substitution reactions with correspondingly monosubstituted piperazines by two methods to the title compounds I-V. Their salts (maleates and hydrochlorides) showed in addition to antitussic activity some anthelmintic effects towards a series of the helminth species.

Preparation of chiral 1-phenylethanols and bromides

1985 ◽  
Vol 63 (12) ◽  
pp. 3442-3448 ◽  
Author(s):  
Allan R. Stein ◽  
Robert D. Dawe ◽  
James R. Sweet
Keyword(s):  
General Procedure ◽  
Optical Purity ◽  
Secondary Alcohols ◽  
One Pot ◽  
Convenient Procedure ◽  
Optical Rotations ◽  
Nmr Methods ◽  
Substituted 1

A fast, convenient procedure for preparing and resolving moderate to large quantities of chiral secondary alcohols is described. The general procedure involves a one-pot conversion of the ketone (various acetophenones) to the half-ester of a diacid (succinic, phthalic… ) and resolution with (+)- and (−)-1-phenylethylamines. Overall yields of the enantiomeric alcohols, the variously substituted 1-phenylethanols, are generally 65–85% with optical purities of approximately 90%. Properties and optical rotations of a number of chiral 1-phenylethanols and of the bromides made from them are tabulated. A discussion of optical purity determinations using nmr methods is included and absolute configurations are reported.

scholarly journals Synthesis of aldehydes and ketones by the dehydrogenation of alcohols in the presence of a Raney nickel/aluminium isopropoxide/alumina catalyst

2004 ◽  
Vol 2 (1) ◽  
pp. 214-219 ◽  
Author(s):  
Ilie Tarta ◽  
Ioan Silberg ◽  
Mircea Vlassa ◽  
Ioan Oprean
Keyword(s):  
Raney Nickel ◽  
Secondary Alcohols ◽  
Aluminium Isopropoxide ◽  
Alumina Catalyst ◽  
Aldehydes And Ketones ◽  
Raney Ni ◽  
Al2o3 Catalyst

AbstractThe synthesis of aldehydes and ketones by the dehydrogenation of allylic and secondary alcohols using a Raney-Ni-Al(i-OPr)3-Al2O3 catalyst without hydrogen acceptors is presented.

Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Nalidixic Acid ◽  
Copper Complexes ◽  
Biological Activities ◽  
Bidentate Coordination ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Oxadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
Derivatives Of ◽  
Substituted 1

A series of novel 1, 3, 4-oxadiazole analogues was synthesized from cyclization of hydrazones of substituted 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazides were prepared from nalidixic acid. The structures of synthesized oxadiazole derivatives and their copper complexes were elucidated on the basis of FTIR, elemental analyses, 1H-NMR and atomic absorption spectral analysis. It was observed from spectral data that metal ligand ratio was 1:1 in all copper complexes and they were bidentate, coordination was found to be done through oxygen of 4-oxo group and nitrogen of oxadiazole ring. The synthesized compounds were further evaluated with biological activities and compared with parent hydrazones. Copper complexes possess antibacterial and antifungal activities better than the oxadiazoles while they have better antioxidant activity then copper complexes. Parent hydrazones were better in all biological activities than synthesized oxadiazoles.

Sign in / Sign up

Export Citation Format

Share Document