scholarly journals Assessment of Oritavancin Serum Protein Binding across Species

2010 ◽  
Vol 54 (8) ◽  
pp. 3481-3483 ◽  
Author(s):  
Francis F. Arhin ◽  
Adam Belley ◽  
Geoffrey McKay ◽  
Sylvain Beaulieu ◽  
Ingrid Sarmiento ◽  
...  
Keyword(s):  
Protein Binding ◽  
Human Serum ◽  
Serum Protein ◽  
Serum Protein Binding ◽  
Drug Adsorption

ABSTRACT Biophysical methods to study the binding of oritavancin, a lipoglycopeptide, to serum protein are confounded by nonspecific drug adsorption to labware surfaces. We assessed oritavancin binding to serum from mouse, rat, dog, and human by a microbiological growth-based method under conditions that allow near-quantitative drug recovery. Protein binding was similar across species, ranging from 81.9% in human serum to 87.1% in dog serum. These estimates support the translation of oritavancin exposure from nonclinical studies to humans.

scholarly journals Analytical and Functional Determination of Polymyxin B Protein Binding in Serum

2015 ◽  
Vol 59 (11) ◽  
pp. 7121-7123 ◽  
Author(s):  
Henrietta Abodakpi ◽  
Jie Gohlke ◽  
Kai-Tai Chang ◽  
Diana S.-L. Chow ◽  
Vincent H. Tam
Keyword(s):  
Protein Binding ◽  
Human Serum ◽  
Serum Protein ◽  
Equilibrium Dialysis ◽  
Polymyxin B ◽  
Functional Assay ◽  
Pharmacological Properties ◽  
Serum Protein Binding

ABSTRACTTo enhance our understanding of the pharmacological properties of polymyxin B, serum protein binding for polymyxin B1, B2, and B3 and for isoleucine-polymyxin B1 was evaluated. Using equilibrium dialysis and ultrafiltration, comparable protein binding was found in all 4 components of polymyxin B (92% to 99%). Protein binding in human serum was further assessed using a functional assay, the results of which were in general agreement with previous findings (approximately 90%).

scholarly journals A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding

2013 ◽  
Vol 42 (33) ◽  
pp. 11841 ◽  
Author(s):  
Gisela Gonçalves ◽  
Isabel Tomaz ◽  
Isabel Correia ◽  
Luís F. Veiros ◽  
M. Margarida C. A. Castro ◽  
...  
Keyword(s):  
Protein Binding ◽  
Human Serum ◽  
Serum Protein ◽  
Serum Protein Binding ◽  
Human Serum Protein ◽  
Synthesis Solution ◽  
Solution Speciation

The Influence of Lactic Acid on the Serum Protein Binding of Bupivacaine

1984 ◽  
Vol 61 (2) ◽  
pp. 127-133 ◽  
Author(s):  
Dennis E. Coyle ◽  
Donald D. Denson ◽  
Gary A. Thompson ◽  
Jane A. Myers ◽  
G. Richard Arthur ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Protein Binding ◽  
Serum Protein ◽  
Serum Protein Binding

Influence of Age and Gender on the In Vitro Serum Protein Binding of Flecainide

1993 ◽  
Vol 28 (3) ◽  
pp. 259-264 ◽  
Author(s):  
R. Zordan ◽  
R. Padrini ◽  
V. Bernini ◽  
D. Piovan ◽  
M. Ferrari
Keyword(s):  
Protein Binding ◽  
Serum Protein ◽  
Serum Protein Binding ◽  
Age And Gender ◽  
And Gender
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