QSAR Modeling of Human Serum Protein Binding with Several Modeling Techniques Utilizing Structure−Information Representation

2006 ◽  
Vol 49 (24) ◽  
pp. 7169-7181 ◽  
Author(s):  
Joseph R. Votano ◽  
Marc Parham ◽  
L. Mark Hall ◽  
Lowell H. Hall ◽  
Lemont B. Kier ◽  
...  
Keyword(s):  
Protein Binding ◽  
Human Serum ◽  
Serum Protein ◽  
Information Representation ◽  
Serum Protein Binding ◽  
Qsar Modeling ◽  
Structure Information ◽  
Modeling Techniques ◽  
Human Serum Protein

scholarly journals A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding

2013 ◽  
Vol 42 (33) ◽  
pp. 11841 ◽  
Author(s):  
Gisela Gonçalves ◽  
Isabel Tomaz ◽  
Isabel Correia ◽  
Luís F. Veiros ◽  
M. Margarida C. A. Castro ◽  
...  
Keyword(s):  
Protein Binding ◽  
Human Serum ◽  
Serum Protein ◽  
Serum Protein Binding ◽  
Human Serum Protein ◽  
Synthesis Solution ◽  
Solution Speciation

scholarly journals Analytical and Functional Determination of Polymyxin B Protein Binding in Serum

2015 ◽  
Vol 59 (11) ◽  
pp. 7121-7123 ◽  
Author(s):  
Henrietta Abodakpi ◽  
Jie Gohlke ◽  
Kai-Tai Chang ◽  
Diana S.-L. Chow ◽  
Vincent H. Tam
Keyword(s):  
Protein Binding ◽  
Human Serum ◽  
Serum Protein ◽  
Equilibrium Dialysis ◽  
Polymyxin B ◽  
Functional Assay ◽  
Pharmacological Properties ◽  
Serum Protein Binding

ABSTRACTTo enhance our understanding of the pharmacological properties of polymyxin B, serum protein binding for polymyxin B1, B2, and B3 and for isoleucine-polymyxin B1 was evaluated. Using equilibrium dialysis and ultrafiltration, comparable protein binding was found in all 4 components of polymyxin B (92% to 99%). Protein binding in human serum was further assessed using a functional assay, the results of which were in general agreement with previous findings (approximately 90%).

scholarly journals Assessment of Oritavancin Serum Protein Binding across Species

2010 ◽  
Vol 54 (8) ◽  
pp. 3481-3483 ◽  
Author(s):  
Francis F. Arhin ◽  
Adam Belley ◽  
Geoffrey McKay ◽  
Sylvain Beaulieu ◽  
Ingrid Sarmiento ◽  
...  
Keyword(s):  
Protein Binding ◽  
Human Serum ◽  
Serum Protein ◽  
Serum Protein Binding ◽  
Drug Adsorption

ABSTRACT Biophysical methods to study the binding of oritavancin, a lipoglycopeptide, to serum protein are confounded by nonspecific drug adsorption to labware surfaces. We assessed oritavancin binding to serum from mouse, rat, dog, and human by a microbiological growth-based method under conditions that allow near-quantitative drug recovery. Protein binding was similar across species, ranging from 81.9% in human serum to 87.1% in dog serum. These estimates support the translation of oritavancin exposure from nonclinical studies to humans.

scholarly journals A study of the binding between radicicol and four proteins by means of spectroscopy and molecular docking

2021 ◽  
pp. 174751982199306
Author(s):  
Ya Gan ◽  
Ning Bai ◽  
Xitong Li ◽  
Shuiting Gao ◽  
Ruiyong Wang
Keyword(s):  
Molecular Docking ◽  
Human Serum ◽  
Serum Protein ◽  
Binding Constant ◽  
Inhibitory Effect ◽  
Experimental Results ◽  
Static Quenching ◽  
Spectroscopic Techniques ◽  
Quenching Process ◽  
Human Serum Protein

The interactions between radicicol and four proteins (catalase, trypsin, pepsin, and human serum protein) are investigated by spectroscopic techniques and molecular docking. A static quenching process is confirmed. The binding constant value between radicicol and human serum protein is the largest among the four proteins. Results reveal changes in the micro-environment of the protein by the addition of radicicol. It is found that radicicol shows an inhibitory effect on the activity of proteins (catalase, trypsin, and pepsin). Molecular docking results are consistent with the thermodynamic experimental results. This work provides clues to the elucidation of the mechanisms of the interactions between radicicol and proteins.

The Influence of Lactic Acid on the Serum Protein Binding of Bupivacaine

1984 ◽  
Vol 61 (2) ◽  
pp. 127-133 ◽  
Author(s):  
Dennis E. Coyle ◽  
Donald D. Denson ◽  
Gary A. Thompson ◽  
Jane A. Myers ◽  
G. Richard Arthur ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Protein Binding ◽  
Serum Protein ◽  
Serum Protein Binding
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