Distribution Coefficients and in Vitro Human Serum Protein Binding of Spironolactone and its 7α-carboxymethyl Analog

1980 ◽  
Vol 69 (1) ◽  
pp. 30-32 ◽  
Author(s):  
Anthony S. Ng ◽  
Ronald B. Kluza ◽  
David W. Newton
Keyword(s):  
Protein Binding ◽  
Human Serum ◽  
Serum Protein ◽  
Distribution Coefficients ◽  
Serum Protein Binding ◽  
Human Serum Protein

scholarly journals A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding

2013 ◽  
Vol 42 (33) ◽  
pp. 11841 ◽  
Author(s):  
Gisela Gonçalves ◽  
Isabel Tomaz ◽  
Isabel Correia ◽  
Luís F. Veiros ◽  
M. Margarida C. A. Castro ◽  
...  
Keyword(s):  
Protein Binding ◽  
Human Serum ◽  
Serum Protein ◽  
Serum Protein Binding ◽  
Human Serum Protein ◽  
Synthesis Solution ◽  
Solution Speciation

Influence of Age and Gender on the In Vitro Serum Protein Binding of Flecainide

1993 ◽  
Vol 28 (3) ◽  
pp. 259-264 ◽  
Author(s):  
R. Zordan ◽  
R. Padrini ◽  
V. Bernini ◽  
D. Piovan ◽  
M. Ferrari
Keyword(s):  
Protein Binding ◽  
Serum Protein ◽  
Serum Protein Binding ◽  
Age And Gender ◽  
And Gender

scholarly journals Analytical and Functional Determination of Polymyxin B Protein Binding in Serum

2015 ◽  
Vol 59 (11) ◽  
pp. 7121-7123 ◽  
Author(s):  
Henrietta Abodakpi ◽  
Jie Gohlke ◽  
Kai-Tai Chang ◽  
Diana S.-L. Chow ◽  
Vincent H. Tam
Keyword(s):  
Protein Binding ◽  
Human Serum ◽  
Serum Protein ◽  
Equilibrium Dialysis ◽  
Polymyxin B ◽  
Functional Assay ◽  
Pharmacological Properties ◽  
Serum Protein Binding

ABSTRACTTo enhance our understanding of the pharmacological properties of polymyxin B, serum protein binding for polymyxin B1, B2, and B3 and for isoleucine-polymyxin B1 was evaluated. Using equilibrium dialysis and ultrafiltration, comparable protein binding was found in all 4 components of polymyxin B (92% to 99%). Protein binding in human serum was further assessed using a functional assay, the results of which were in general agreement with previous findings (approximately 90%).

scholarly journals In Vivo and in Vitro Serum Protein Binding of Sulfonamides in Rabbits

1985 ◽  
Vol 105 (12) ◽  
pp. 1188-1191
Author(s):  
YORISHIGE IMAMURA ◽  
RAMONLOO ELIO ◽  
HIROYUKI MORI ◽  
MASAKI OTAGIRI
Keyword(s):  
Protein Binding ◽  
Serum Protein ◽  
Serum Protein Binding
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