scholarly journals Organization of feed-forward loop motifs reveals architectural principles in natural and engineered networks

2018 ◽  
Vol 4 (3) ◽  
pp. eaap9751 ◽  
Author(s):  
Thomas E. Gorochowski ◽  
Claire S. Grierson ◽  
Mario di Bernardo
Keyword(s):  
Feed Forward ◽  
Feed Forward Loop ◽  
Architectural Principles

scholarly journals Organisation of feed-forward loop motifs reveals architectural principles in natural and engineered networks

2017 ◽  
Author(s):  
Thomas E. Gorochowski ◽  
Claire S. Grierson ◽  
Mario di Bernardo
Keyword(s):  
Escherichia Coli ◽  
Functional Analysis ◽  
Broad Spectrum ◽  
Building Blocks ◽  
Networked Systems ◽  
Network Motifs ◽  
Feed Forward ◽  
Feed Forward Loop ◽  
Architectural Principles ◽  
Important Nodes

AbstractNetwork motifs are significantly expressed sub-graphs that have been proposed as building blocks for natural and engineered networks. Detailed functional analysis has been performed for many types of motif in isolation, but less is known about how motifs work together to perform complex tasks. To address this issue we measure the aggregation of network motifs via methods that extract precisely how these structures are connected. Applying this approach to a broad spectrum of networked systems and focusing on the widespread feed-forward loop motif, we uncover striking differences in motif organisation. The types of connection are often highly constrained, differ between domains, and clearly capture architectural principles. We show how this information can be used to effectively predict functionally important nodes in the metabolic network ofEscherichia coli. Our findings have implications for understanding how networked systems are constructed from motif parts and elucidates constraints that guide their evolution.

scholarly journals Cell-Free Characterization of Coherent Feed-Forward Loop-Based Synthetic Genetic Circuits

2021 ◽  
Author(s):  
Pascal A. Pieters ◽  
Bryan L. Nathalia ◽  
Ardjan J. van der Linden ◽  
Peng Yin ◽  
Jongmin Kim ◽  
...  
Keyword(s):  
Genetic Circuits ◽  
Feed Forward ◽  
Feed Forward Loop

scholarly journals Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

2013 ◽  
Vol 123 (7) ◽  
pp. 3183-3183 ◽  
Author(s):  
Sampurna Chatterjee ◽  
Lukas C. Heukamp ◽  
Maike Siobal ◽  
Jakob Schöttle ◽  
Caroline Wieczorek ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Feed Forward ◽  
Feed Forward Loop

scholarly journals A feed-forward loop guarantees robust behavior in Escherichia coli carbohydrate uptake

2008 ◽  
Vol 24 (5) ◽  
pp. 704-710 ◽  
Author(s):  
A. Kremling ◽  
K. Bettenbrock ◽  
E. D. Gilles
Keyword(s):  
Escherichia Coli ◽  
Feed Forward ◽  
Feed Forward Loop

Semaphorin 4A acts in a feed-forward loop with NF-κB pathway to exacerbate catabolic effect of IL-1β on chondrocytes

2019 ◽  
Vol 69 ◽  
pp. 88-94 ◽  
Author(s):  
Hua Zhang ◽  
Qiushi Wei ◽  
Xiaobing Xiang ◽  
Bengen Zhou ◽  
Jianfa Chen ◽  
...  
Keyword(s):  
Feed Forward ◽  
Feed Forward Loop

scholarly journals Subclinical atherosclerosis and its progression are modulated byPLIN2through a feed‐forward loop between LXR and autophagy

2019 ◽  
Vol 286 (6) ◽  
pp. 660-675 ◽  
Author(s):  
P. Saliba‐Gustafsson ◽  
M. Pedrelli ◽  
K. Gertow ◽  
O. Werngren ◽  
V. Janas ◽  
...  
Keyword(s):  
Subclinical Atherosclerosis ◽  
Feed Forward ◽  
Feed Forward Loop
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