scholarly journals Subclinical atherosclerosis and its progression are modulated byPLIN2through a feed‐forward loop between LXR and autophagy

2019 ◽  
Vol 286 (6) ◽  
pp. 660-675 ◽  
Author(s):  
P. Saliba‐Gustafsson ◽  
M. Pedrelli ◽  
K. Gertow ◽  
O. Werngren ◽  
V. Janas ◽  
...  
Keyword(s):  
Subclinical Atherosclerosis ◽  
Feed Forward ◽  
Feed Forward Loop

P728Subclinical atherosclerosis and its progression are modulated by perilipin-2 through a feed-forward loop between LXR and autophagy

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
E Ehrenborg ◽  
P Saliba Gustafsson ◽  
M Pedrelli ◽  
K Gertow ◽  
S Pourteymour ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Feed Forward ◽  
Feed Forward Loop ◽  
Beneficial Effects ◽  
Media Thickness ◽  
Primary Monocyte ◽  
Perilipin 2 ◽  
Autophagy Activity

Abstract Background Hyperlipidemia is a major risk factor for cardiovascular disease and atherosclerosis is the underlying cause of both myocardial infarction and stroke. We have previously shown that the Pro251 variant of perilipin-2 reduces plasma triglycerides and may therefore be beneficial for atherosclerosis development. Purpose We sought to delineate putative beneficial effects of the Pro251 variant of perlipin-2 on subclinical atherosclerosis and the mechanism by which it acts. Methods A pan-European cohort of high-risk individuals where carotid intima-media thickness has been assessed was adopted. Human primary monocyte-derived macrophages were prepared from whole blood from individuals recruited by perilipin-2 genotype, or from buffy coats from the our University hospital blood central. Results The Pro251 variant of perilipin-2 is associated with decreased intima-media thickness at baseline and 30 months follow-up. Using human primary monocyte-derived macrophages from carriers of the beneficial Pro251 variant we show that this variant increases autophagy activity, cholesterol efflux, and a controlled inflammatory response. Through extensive mechanistic studies we demonstrate that increase in autophagy activity is accompanied with an increase in LXR activity and that LXR and autophagy reciprocally activate each other in a feed-forward loop, regulated by CYP27A1 and 27OH-cholesterol. Conclusions For the first time, we show that perilipin-2 affects susceptibility to human atherosclerosis through activation of autophagy and stimulation of cholesterol efflux. We demonstrate that perilipin-2 modulates levels of the LXR ligand 27OH-cholesterol and initiates a feed-forward loop where LXR and autophagy reciprocally activate each other; the mechanism by which perilipin-2 exerts its beneficial effects on subclinical atherosclerosis. Acknowledgement/Funding The Swedish Research Council, Swedish Heart-Lung Foundation, Marianne and Marcus Wallenberg's Foundation, Swedish Medical Society

Subclinical Atherosclerosis And Its Progression Is Modulated By Plin2 Through A Feed-Forward Loop Between Lxr And Autophagy

2019 ◽  
Vol 287 ◽  
pp. e55-e56
Author(s):  
S. Pourteymour ◽  
P. Saliba Gustafsson ◽  
M. Pedrelli ◽  
K. Gertow ◽  
O. Werngren ◽  
...  
Keyword(s):  
Subclinical Atherosclerosis ◽  
Feed Forward ◽  
Feed Forward Loop

scholarly journals Cell-Free Characterization of Coherent Feed-Forward Loop-Based Synthetic Genetic Circuits

2021 ◽  
Author(s):  
Pascal A. Pieters ◽  
Bryan L. Nathalia ◽  
Ardjan J. van der Linden ◽  
Peng Yin ◽  
Jongmin Kim ◽  
...  
Keyword(s):  
Genetic Circuits ◽  
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Feed Forward Loop

scholarly journals Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

2013 ◽  
Vol 123 (7) ◽  
pp. 3183-3183 ◽  
Author(s):  
Sampurna Chatterjee ◽  
Lukas C. Heukamp ◽  
Maike Siobal ◽  
Jakob Schöttle ◽  
Caroline Wieczorek ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Feed Forward ◽  
Feed Forward Loop

scholarly journals A feed-forward loop guarantees robust behavior in Escherichia coli carbohydrate uptake

2008 ◽  
Vol 24 (5) ◽  
pp. 704-710 ◽  
Author(s):  
A. Kremling ◽  
K. Bettenbrock ◽  
E. D. Gilles
Keyword(s):  
Escherichia Coli ◽  
Feed Forward ◽  
Feed Forward Loop

Semaphorin 4A acts in a feed-forward loop with NF-κB pathway to exacerbate catabolic effect of IL-1β on chondrocytes

2019 ◽  
Vol 69 ◽  
pp. 88-94 ◽  
Author(s):  
Hua Zhang ◽  
Qiushi Wei ◽  
Xiaobing Xiang ◽  
Bengen Zhou ◽  
Jianfa Chen ◽  
...  
Keyword(s):  
Feed Forward ◽  
Feed Forward Loop
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