scholarly journals A feed-forward loop guarantees robust behavior in Escherichia coli carbohydrate uptake

2008 ◽  
Vol 24 (5) ◽  
pp. 704-710 ◽  
Author(s):  
A. Kremling ◽  
K. Bettenbrock ◽  
E. D. Gilles
Keyword(s):  
Escherichia Coli ◽  
Feed Forward ◽  
Feed Forward Loop

The Incoherent Feed-forward Loop Accelerates the Response-time of the gal System of Escherichia coli

2006 ◽  
Vol 356 (5) ◽  
pp. 1073-1081 ◽  
Author(s):  
S. Mangan ◽  
S. Itzkovitz ◽  
A. Zaslaver ◽  
U. Alon
Keyword(s):  
Escherichia Coli ◽  
Response Time ◽  
Feed Forward ◽  
Feed Forward Loop

scholarly journals Organisation of feed-forward loop motifs reveals architectural principles in natural and engineered networks

2017 ◽  
Author(s):  
Thomas E. Gorochowski ◽  
Claire S. Grierson ◽  
Mario di Bernardo
Keyword(s):  
Escherichia Coli ◽  
Functional Analysis ◽  
Broad Spectrum ◽  
Building Blocks ◽  
Networked Systems ◽  
Network Motifs ◽  
Feed Forward ◽  
Feed Forward Loop ◽  
Architectural Principles ◽  
Important Nodes

AbstractNetwork motifs are significantly expressed sub-graphs that have been proposed as building blocks for natural and engineered networks. Detailed functional analysis has been performed for many types of motif in isolation, but less is known about how motifs work together to perform complex tasks. To address this issue we measure the aggregation of network motifs via methods that extract precisely how these structures are connected. Applying this approach to a broad spectrum of networked systems and focusing on the widespread feed-forward loop motif, we uncover striking differences in motif organisation. The types of connection are often highly constrained, differ between domains, and clearly capture architectural principles. We show how this information can be used to effectively predict functionally important nodes in the metabolic network ofEscherichia coli. Our findings have implications for understanding how networked systems are constructed from motif parts and elucidates constraints that guide their evolution.

scholarly journals Cell-Free Characterization of Coherent Feed-Forward Loop-Based Synthetic Genetic Circuits

2021 ◽  
Author(s):  
Pascal A. Pieters ◽  
Bryan L. Nathalia ◽  
Ardjan J. van der Linden ◽  
Peng Yin ◽  
Jongmin Kim ◽  
...  
Keyword(s):  
Genetic Circuits ◽  
Feed Forward ◽  
Feed Forward Loop

scholarly journals Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

2013 ◽  
Vol 123 (7) ◽  
pp. 3183-3183 ◽  
Author(s):  
Sampurna Chatterjee ◽  
Lukas C. Heukamp ◽  
Maike Siobal ◽  
Jakob Schöttle ◽  
Caroline Wieczorek ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Feed Forward ◽  
Feed Forward Loop

Development of an Algorithm for Feed-Forward Chlorine Dosing of Lettuce Wash Operations and Correlation of Chlorine Profile with Escherichia coli O157:H7 Inactivation

2014 ◽  
Vol 77 (4) ◽  
pp. 558-566 ◽  
Author(s):  
BIN ZHOU ◽  
YAGUANG LUO ◽  
XIANGWU NOU ◽  
PATRICIA MILLNER
Keyword(s):  
Escherichia Coli ◽  
Reduction Potential ◽  
Free Chlorine ◽  
Organic Load ◽  
Escherichia Coli O157 ◽  
Feed Forward ◽  
E Coli ◽  
Wash Solution ◽  
Oxidation Reduction ◽  
Oxidation Reduction Potential

The dynamic interactions of chlorine and organic matter during a simulated fresh-cut produce wash process and the consequences for Escherichia coli O157:H7 inactivation were investigated. An algorithm for a chlorine feed-forward dosing scheme to maintain a stable chlorine level was further developed and validated. Organic loads with chemical oxygen demand of 300 to 800 mg/liter were modeled using iceberg lettuce. Sodium hypochlorite (NaOCl) was added to the simulated wash solution incrementally. The solution pH, free and total chlorine, and oxidation-reduction potential were monitored, and chlorination breakpoint and chloramine humps determined. The results indicated that the E. coli O157:H7 inactivation curve mirrored that of the free chlorine during the chlorine replenishment process: a slight reduction in E. coli O157:H7 was observed as the combined chlorine hump was approached, while the E. coli O157:H7 cell populations declined sharply after chlorination passed the chlorine hump and decreased to below the detection limit (<0.75 most probable number per ml) after the chlorination breakpoint was reached. While the amounts of NaOCl required for reaching the chloramine humps and chlorination breakpoints depended on the organic loads, there was a linear correlation between NaOCl input and free chlorine in the wash solution once NaOCl dosing passed the chlorination breakpoint, regardless of organic load. The data obtained were further exploited to develop a NaOCl dosing algorithm for maintaining a stable chlorine concentration in the presence of an increasing organic load. The validation tests results indicated that free chlorine could be maintained at target levels using such an algorithm, while the pH and oxidation-reduction potential were also stably maintained using this system.

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