Determination of Time-Dependent Inactivation of CYP3A4 in Cryopreserved Human Hepatocytes and Assessment of Human Drug-Drug Interactions

2011 ◽  
Vol 39 (11) ◽  
pp. 2085-2092 ◽  
Author(s):  
Yuan Chen ◽  
Liling Liu ◽  
Mario Monshouwer ◽  
Adrian J. Fretland
Keyword(s):  
Drug Interactions ◽  
Human Hepatocytes ◽  
Time Dependent ◽  
Dependent Inactivation

EVALUATION OF TIME-DEPENDENT INACTIVATION OF CYP3A IN CRYOPRESERVED HUMAN HEPATOCYTES

2005 ◽  
Vol 33 (6) ◽  
pp. 853-861 ◽  
Author(s):  
Ping Zhao ◽  
Kent L. Kunze ◽  
Caroline A. Lee
Keyword(s):  
Human Hepatocytes ◽  
Time Dependent ◽  
Dependent Inactivation

Kinetics of the time-dependent inactivation of CYP2D6 in cryopreserved human hepatocytes by methylenedioxymethamphetamine (MDMA)

2007 ◽  
Vol 31 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Linh M. Van ◽  
John Swales ◽  
Clare Hammond ◽  
Claire Wilson ◽  
Judith A. Hargreaves ◽  
...  
Keyword(s):  
Human Hepatocytes ◽  
Time Dependent ◽  
Dependent Inactivation ◽  
Kinetics Of

scholarly journals Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Anne M. Filppula ◽  
Rezvan Parvizi ◽  
André Mateus ◽  
Pawel Baranczewski ◽  
Per Artursson
Keyword(s):  
Drug Interactions ◽  
Time Dependent ◽  
Drug Concentrations

scholarly journals Determination of time-dependent strengths of salt pillars based on strain energy principle

2019 ◽  
Vol 29 (2) ◽  
pp. 273-279 ◽  
Author(s):  
Prapasiri Junthong ◽  
Supattra Khamrat ◽  
Suratwadee Sartkaew ◽  
Kittitep Fuenkajorn
Keyword(s):  
Strain Energy ◽  
Time Dependent ◽  
Energy Principle

Moment-tensor solutions for the 24 November 1987 Superstition Hills, California, earthquakes

1989 ◽  
Vol 79 (2) ◽  
pp. 493-499
Author(s):  
Stuart A. Sipkin
Keyword(s):  
Main Shock ◽  
Moment Tensor ◽  
Time Dependent ◽  
Origin Time ◽  
Data Set ◽  
Filter Theory ◽  
Long Period ◽  
Seismograph Network ◽  
Scalar Moment

Abstract The teleseismic long-period waveforms recorded by the Global Digital Seismograph Network from the two largest Superstition Hills earthquakes are inverted using an algorithm based on optimal filter theory. These solutions differ slightly from those published in the Preliminary Determination of Epicenters Monthly Listing because a somewhat different, improved data set was used in the inversions and a time-dependent moment-tensor algorithm was used to investigate the complexity of the main shock. The foreshock (origin time 01:54:14.5, mb 5.7, Ms 6.2) had a scalar moment of 2.3 × 1025 dyne-cm, a depth of 8 km, and a mechanism of strike 217°, dip 79°, rake 4°. The main shock (origin time 13:15:56.4, mb 6.0, Ms 6.6) was a complex event, consisting of at least two subevents, with a combined scalar moment of 1.0 × 1026 dyne-cm, a depth of 10 km, and a mechanism of strike 303°, dip 89°, rake −180°.

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