Role of Intestinal Cytochrome P450 (P450) in Modulating the Bioavailability of Oral Lovastatin: Insights from Studies on the Intestinal Epithelium-Specific P450 Reductase Knockout Mouse

Yi Zhu; Jaime D'Agostino; Qing-Yu Zhang

doi:10.1124/dmd.110.037861

Role of Intestinal Cytochrome P450 (P450) in Modulating the Bioavailability of Oral Lovastatin: Insights from Studies on the Intestinal Epithelium-Specific P450 Reductase Knockout Mouse

Drug Metabolism and Disposition ◽

10.1124/dmd.110.037861 ◽

2011 ◽

Vol 39 (6) ◽

pp. 939-943 ◽

Cited By ~ 26

Author(s):

Yi Zhu ◽

Jaime D'Agostino ◽

Qing-Yu Zhang

Keyword(s):

Cytochrome P450 ◽

Intestinal Epithelium ◽

Knockout Mouse ◽

P450 Reductase

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An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine

Drug Metabolism and Disposition ◽

10.1124/dmd.108.025429 ◽

2008 ◽

Vol 37 (3) ◽

pp. 651-657 ◽

Cited By ~ 43

Author(s):

Qing-Yu Zhang ◽

Cheng Fang ◽

Jin Zhang ◽

Deborah Dunbar ◽

Laurence Kaminsky ◽

...

Keyword(s):

Cytochrome P450 ◽

Mouse Model ◽

Intestinal Epithelium ◽

Knockout Mouse ◽

Direct Evidence ◽

Knockout Mouse Model ◽

P450 Reductase ◽

First Pass

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Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)67801-4 ◽

1991 ◽

Vol 266 (6) ◽

pp. 3372-3375

Author(s):

T Shimizu ◽

T Tateishi ◽

M Hatano ◽

Y Fujii-Kuriyama

Keyword(s):

Cytochrome P450 ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Catalytic Function ◽

Nadph Cytochrome P450 Reductase

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Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase. Implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

Anti-Cancer Drugs ◽

10.1097/cad.0b013e32834fcf4f ◽

2012 ◽

Vol 23 (4) ◽

pp. 393-405 ◽

Cited By ~ 5

Author(s):

Dorota Kostrzewa-Nowak ◽

Bohdan Bieg ◽

Mark J.I. Paine ◽

C. Roland Wolf ◽

Jolanta Tarasiuk

Keyword(s):

Cytochrome P450 ◽

Multidrug Resistant ◽

Structural Factors ◽

Cytochrome P450 Reductase ◽

Hl60 Cells ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anthraquinone Derivatives ◽

Nadph Cytochrome P450 Reductase

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Role of the prosthetic groups of NADPH-cytochrome P450 reductase in 3-hydroxyanthranilamide-catalyzed, NADPH-dependent superoxide anion production

Redox Report ◽

10.1080/13510002.1996.11747070 ◽

1996 ◽

Vol 2 (5) ◽

pp. 339-344

Author(s):

Y. Ohta ◽

R. Shinohara ◽

I. Ishiguro

Keyword(s):

Cytochrome P450 ◽

Superoxide Anion ◽

Cytochrome P450 Reductase ◽

Superoxide Anion Production ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anion Production ◽

Nadph Cytochrome P450 Reductase ◽

Prosthetic Groups

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New insights into the role of cytochrome P450 reductase (POR) in microsomal redox biology

Acta Pharmaceutica Sinica B ◽

10.1016/j.apsb.2012.02.002 ◽

2012 ◽

Vol 2 (2) ◽

pp. 102-106 ◽

Cited By ~ 11

Author(s):

Todd D. Porter

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

Redox Biology ◽

P450 Reductase

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Conformational Dynamics and the Energetics of Protein−Ligand Interactions: Role of Interdomain Loop in Human Cytochrome P450 Reductase†

Biochemistry ◽

10.1021/bi700596s ◽

2007 ◽

Vol 46 (28) ◽

pp. 8244-8255 ◽

Cited By ~ 23

Author(s):

Alex Grunau ◽

Kalotina Geraki ◽

J. Günter Grossmann ◽

Aldo Gutierrez

Keyword(s):

Cytochrome P450 ◽

Conformational Dynamics ◽

Cytochrome P450 Reductase ◽

P450 Reductase ◽

Protein Ligand Interactions ◽

Human Cytochrome ◽

Ligand Interactions

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Determination of the Role of Target Tissue Metabolism in Lung Carcinogenesis Using Conditional Cytochrome P450 Reductase-Null Mice

Cancer Research ◽

10.1158/0008-5472.can-07-1006 ◽

2007 ◽

Vol 67 (16) ◽

pp. 7825-7832 ◽

Cited By ~ 64

Author(s):

Yan Weng ◽

Cheng Fang ◽

Robert J. Turesky ◽

Melissa Behr ◽

Laurence S. Kaminsky ◽

...

Keyword(s):

Cytochrome P450 ◽

Target Tissue ◽

Cytochrome P450 Reductase ◽

Lung Carcinogenesis ◽

Tissue Metabolism ◽

P450 Reductase

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Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2019.01.020 ◽

2019 ◽

Vol 366 ◽

pp. 64-74 ◽

Cited By ~ 1

Author(s):

Lindsay Reed ◽

Radek Indra ◽

Iveta Mrizova ◽

Michaela Moserova ◽

Heinz H. Schmeiser ◽

...

Keyword(s):

Cytochrome P450 ◽

Cytochrome B ◽

Anticancer Drug ◽

P450 Reductase ◽

Hepatic Cytochrome

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Effector role of cytochrome P450 reductase for androstenedione binding to human aromatase

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2020.07.163 ◽

2020 ◽

Vol 164 ◽

pp. 510-517 ◽

Cited By ~ 2

Author(s):

Chao Zhang ◽

Gianluca Catucci ◽

Giovanna Di Nardo ◽

Gianfranco Gilardi

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

P450 Reductase ◽

Human Aromatase

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Role of LYS271 and LYS279 Residues in the Interaction of Cytochrome P4501A1 with NADPH–Cytochrome P450 Reductase

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.2000.2174 ◽

2001 ◽

Vol 385 (2) ◽

pp. 290-300 ◽

Cited By ~ 9

Author(s):

Tomas Cvrk ◽

Henry W. Strobel

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

Cytochrome P4501a1 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

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