Conformational Dynamics and the Energetics of Protein−Ligand Interactions:  Role of Interdomain Loop in Human Cytochrome P450 Reductase†

Alex Grunau; Kalotina Geraki; J. Günter Grossmann; Aldo Gutierrez

doi:10.1021/bi700596s

Conformational Dynamics and the Energetics of Protein−Ligand Interactions: Role of Interdomain Loop in Human Cytochrome P450 Reductase†

Biochemistry ◽

10.1021/bi700596s ◽

2007 ◽

Vol 46 (28) ◽

pp. 8244-8255 ◽

Cited By ~ 23

Author(s):

Alex Grunau ◽

Kalotina Geraki ◽

J. Günter Grossmann ◽

Aldo Gutierrez

Keyword(s):

Cytochrome P450 ◽

Conformational Dynamics ◽

Cytochrome P450 Reductase ◽

P450 Reductase ◽

Protein Ligand Interactions ◽

Human Cytochrome ◽

Ligand Interactions

Download Full-text

Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ◽

10.1016/s0027-5107(01)00223-8 ◽

2001 ◽

Vol 483 (1-2) ◽

pp. 35-41 ◽

Cited By ~ 40

Author(s):

Ken-ichi Fujita ◽

Tetsuya Kamataki

Keyword(s):

Cytochrome P450 ◽

Salmonella Typhimurium ◽

Metabolic Activation ◽

Genetically Engineered ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Human Cytochrome ◽

Nadph Cytochrome P450 Reductase

Download Full-text

Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)67801-4 ◽

1991 ◽

Vol 266 (6) ◽

pp. 3372-3375

Author(s):

T Shimizu ◽

T Tateishi ◽

M Hatano ◽

Y Fujii-Kuriyama

Keyword(s):

Cytochrome P450 ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Catalytic Function ◽

Nadph Cytochrome P450 Reductase

Download Full-text

Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase. Implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

Anti-Cancer Drugs ◽

10.1097/cad.0b013e32834fcf4f ◽

2012 ◽

Vol 23 (4) ◽

pp. 393-405 ◽

Cited By ~ 5

Author(s):

Dorota Kostrzewa-Nowak ◽

Bohdan Bieg ◽

Mark J.I. Paine ◽

C. Roland Wolf ◽

Jolanta Tarasiuk

Keyword(s):

Cytochrome P450 ◽

Multidrug Resistant ◽

Structural Factors ◽

Cytochrome P450 Reductase ◽

Hl60 Cells ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anthraquinone Derivatives ◽

Nadph Cytochrome P450 Reductase

Download Full-text

Role of the prosthetic groups of NADPH-cytochrome P450 reductase in 3-hydroxyanthranilamide-catalyzed, NADPH-dependent superoxide anion production

Redox Report ◽

10.1080/13510002.1996.11747070 ◽

1996 ◽

Vol 2 (5) ◽

pp. 339-344

Author(s):

Y. Ohta ◽

R. Shinohara ◽

I. Ishiguro

Keyword(s):

Cytochrome P450 ◽

Superoxide Anion ◽

Cytochrome P450 Reductase ◽

Superoxide Anion Production ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anion Production ◽

Nadph Cytochrome P450 Reductase ◽

Prosthetic Groups

Download Full-text

New insights into the role of cytochrome P450 reductase (POR) in microsomal redox biology

Acta Pharmaceutica Sinica B ◽

10.1016/j.apsb.2012.02.002 ◽

2012 ◽

Vol 2 (2) ◽

pp. 102-106 ◽

Cited By ~ 11

Author(s):

Todd D. Porter

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

Redox Biology ◽

P450 Reductase

Download Full-text

Co-Expression of Recombinant Human CYP2C9 with Human Cytochrome P450 Reductase in Protease Deficient S. cerevisiae Strain at a Higher Scale Yields an Enzyme of Higher Specific Activity

Drug Metabolism Letters ◽

10.2174/187231210792928233 ◽

2010 ◽

Vol 4 (4) ◽

pp. 246-253 ◽

Cited By ~ 3

Author(s):

K. N. Purnachandra Rao ◽

Sunil Kumar Suman ◽

Y. Ravi Kiran ◽

Arup Ranjan Kuanr ◽

Anuj Kumar Gupta ◽

...

Keyword(s):

Cytochrome P450 ◽

Specific Activity ◽

Cytochrome P450 Reductase ◽

P450 Reductase ◽

Human Cytochrome ◽

Protease Deficient

Download Full-text

Understanding the Role of Conformational Dynamics in Protein-Ligand Interactions Using NMR Relaxation Methods

Encyclopedia of Magnetic Resonance ◽

10.1002/9780470034590.emrstm1363 ◽

2014 ◽

pp. 255-266 ◽

Cited By ~ 1

Author(s):

Asli Ertekin ◽

Francesca Massi

Keyword(s):

Conformational Dynamics ◽

Nmr Relaxation ◽

Relaxation Methods ◽

Protein Ligand Interactions ◽

Ligand Interactions

Download Full-text

Construction ofSalmonella typhimurium YG7108 strains, each coexpressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase

Environmental and Molecular Mutagenesis ◽

10.1002/em.10034 ◽

2001 ◽

Vol 38 (4) ◽

pp. 329-338 ◽

Cited By ~ 14

Author(s):

Ken-ichi Fujita ◽

Kazuo Nakayama ◽

Yoshiyuki Yamazaki ◽

Kazuhiro Tsuruma ◽

Masami Yamada ◽

...

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Human Cytochrome ◽

Nadph Cytochrome P450 Reductase

Download Full-text

Determination of the Role of Target Tissue Metabolism in Lung Carcinogenesis Using Conditional Cytochrome P450 Reductase-Null Mice

Cancer Research ◽

10.1158/0008-5472.can-07-1006 ◽

2007 ◽

Vol 67 (16) ◽

pp. 7825-7832 ◽

Cited By ~ 64

Author(s):

Yan Weng ◽

Cheng Fang ◽

Robert J. Turesky ◽

Melissa Behr ◽

Laurence S. Kaminsky ◽

...

Keyword(s):

Cytochrome P450 ◽

Target Tissue ◽

Cytochrome P450 Reductase ◽

Lung Carcinogenesis ◽

Tissue Metabolism ◽

P450 Reductase

Download Full-text

Drug-Drug Interactions Evaluated by a Highly Active Reconstituted Native Human Cytochrome P4503A4 and Human NADPH-Cytochrome P450 Reductase System

Arzneimittelforschung ◽

10.1055/s-0031-1296940 ◽

2011 ◽

Vol 54 (01) ◽

pp. 78-83

Author(s):

Thomas Haehner ◽

Mohamed Refaie ◽

Dieter Müller-Enoch

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Highly Active ◽

Human Cytochrome ◽

Nadph Cytochrome P450 Reductase

Download Full-text