Extrinsic talker normalization via rapid accumulation of talker-specific phonetic detail

2016 ◽  
Vol 139 (4) ◽  
pp. 2019-2019
Author(s):  
Tyler Perrachione ◽  
Ja Young Choi
Keyword(s):  
Phonetic Detail ◽  
Rapid Accumulation ◽  
Talker Normalization

Intrathoracic Platelet Accumulation in the Guinea-Pig Induced by Intravenous Administration of Arachidonic Acid - Effect of Cyclooxygenase and Thromboxane Synthetase Inhibitors

1986 ◽  
Vol 56 (03) ◽  
pp. 311-317 ◽  
Author(s):  
P A Barrett ◽  
K D Butler ◽  
R A Shand ◽  
R B Wallis
Keyword(s):  
Arachidonic Acid ◽  
Blood Volume ◽  
Intravenous Administration ◽  
Guinea Pigs ◽  
Human Albumin ◽  
Thromboxane Synthetase ◽  
Acid Effect ◽  
Rapid Accumulation ◽  
Platelet Accumulation ◽  
High Doses

SummaryIntravenous administration of arachidonic acid to guinea-pigs caused a dose-related, rapid accumulation of 51Cr-labelled platelets in the thorax. Inhibitors of cyclooxygenase inhibited the platelet accumulation, induced by arachidonic acid (30 mg/kg), at doses which did not alter the thoracic blood volume (as measured by 131I-labelled human albumin). Thromboxane synthetase inhibitors had different effects on platelet accumulation depending on the dose. CGS 12970 (3 mg/kg) and N(1-carboxyheptyl) imidazole (100 mg/kg) reduced platelet accumulation. High doses of CGS 12970 and CGS 13080 caused an apparent enhancement of platelet accumulation which was associated with pooling of blood in the thorax, as measured by either 131I-labelled human albumin or 51Cr-labelled erythrocytes. This increase in thoracic blood volume was abolished if the guinea-pigs were also pretreated with diclofenac (1 mg/kg) in addition to the thromboxane synthetase inhibitor. Increases in thoracic blood volume were also obtained following infusions of PGI2 but not PGD2 or PGE2.

scholarly journals Inhibition of etoposide-induced apoptosis with peptide aldehyde inhibitors of proteasome

1998 ◽  
Vol 332 (3) ◽  
pp. 661-665 ◽  
Author(s):  
Claudio STEFANELLI ◽  
Francesca BONAVITA ◽  
Ivana STANIC ◽  
Carla PIGNATTI ◽  
Giovanna FARRUGGIA ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
P53 Protein ◽  
Proteasome Inhibitors ◽  
Caspase Activity ◽  
Peptide Aldehydes ◽  
Rapid Accumulation ◽  
Apoptotic Effect ◽  
Induced Apoptosis ◽  
Inhibitor Of Protein Synthesis ◽  
Cell Suicide

Recent investigations have indicated the involvement of proteasome in programmed cell death. The present studies show that although peptide aldehyde inhibitors of proteasome are by themselves weak inducers of apoptosis, they inhibit the apoptotic effect of the anticancer drug etoposide in rat thymocytes. Acetyl-Leu-Leu-norvalinal (LLnV-al) and other related peptide aldehydes inhibited the increase in caspase activity and DNA fragmentation that followed treatment with etoposide and their effect was related to their potency as proteasome inhibitors. To inhibit etoposide-induced apoptosis, LLnV-al must be present within 3 h of treatment with etoposide, in the same way as the inhibitor of protein synthesis cycloheximide must be. Etoposide caused a rapid accumulation of p53 protein that was not inhibited by LLnV-al, which was also a strong inducer of p53. Peptide aldehydes were also weak activators of caspase activity, suggesting that the same mechanism, i.e. the blocking of proteasome function, both triggers apoptosis and inhibits the effect of etoposide. These results are consistent with a model in which proteasome is selectively involved in the pathway used by etoposide to induce cell suicide.

Effects of acoustic–phonetic detail on cross-language speech production

2014 ◽  
Vol 77 ◽  
pp. 1-24 ◽  
Author(s):  
Colin Wilson ◽  
Lisa Davidson ◽  
Sean Martin
Keyword(s):  
Speech Production ◽  
Phonetic Detail ◽  
Cross Language

scholarly journals Rapid accumulation and low degradation: key parameters of Tomato yellow leaf curl virus persistence in its insect vector Bemisia tabaci

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Nathalie Becker ◽  
Loup Rimbaud ◽  
Frédéric Chiroleu ◽  
Bernard Reynaud ◽  
Gaël Thébaud ◽  
...  
Keyword(s):  
Bemisia Tabaci ◽  
Tomato Yellow Leaf ◽  
Insect Vector ◽  
Yellow Leaf ◽  
Virus Persistence ◽  
Rapid Accumulation ◽  
Leaf Curl Virus ◽  
Leaf Curl

scholarly journals What Paradox? Referential Cues Allow for Infant Use of Phonetic Detail in Word Learning

2010 ◽  
Vol 81 (5) ◽  
pp. 1376-1383 ◽  
Author(s):  
Christopher T. Fennell ◽  
Sandra R. Waxman
Keyword(s):  
Word Learning ◽  
Phonetic Detail

Ontogeny of tracheal fluid, pulmonary surfactant, and plasma corticoids in the fetal lamb

1975 ◽  
Vol 39 (6) ◽  
pp. 1017-1021 ◽  
Author(s):  
E. J. Mescher ◽  
A. C. Platzker ◽  
P. L. Ballard ◽  
J. A. Kitterman ◽  
J. A. Clements ◽  
...  
Keyword(s):  
Pulmonary Surfactant ◽  
Electrolyte Composition ◽  
Plasma Sodium ◽  
Sudden Increase ◽  
Fetal Plasma ◽  
A Value ◽  
Fetal Lamb ◽  
Rapid Accumulation ◽  
Fluid Production ◽  
Change In Mean

We examined fetal plasma corticoids and flow rate, electrolyte composition, and surfactant content of tracheal fluid in chronic experiments with eight fetal lambs. From 120 to 148 days of gestation the rate of fluid production was 4.5 ml/kg per h, and there was no change in mean fluid sodium (147.8 meq/1), chloride (153.1 meq/1), calcium (2.2 mg/100 ml), and pH (6.23). Tracheal fluid potassium increased from 4.3 meq/1 at 120–130 days to 8.9 meq/1 at term, while plasma sodium, chloride, calcium, pH, and potassium were constant at 146.1 meq/1, 110.0 meq/1, 12.1 mg/100 ml, 7.39, and 4.0 meq/1, respectively. Plasma corticoids were less than 1.5 mug/100 ml total (0.3 mug/100 ml free) until 130 days, when they increased rapidly to 10.5 total (3.2 free) at 148 days. Surfactant was first detected in tracheal fluid between 124 and 133 days and its secretion increased rapidly after 135 days to a value of 125 mug/kg per h at 148 days. A sudden increase in fetal plasma corticoids does not seem to be the stimulus for appearance of surfactant in the lamb, although these hormones may induce the rapid accumulation of surfactant prior to delivery.

High-resolution radiocarbon dating to reconstruct last century environmental changes in the pacific island of Espiritu Santo

2021 ◽  
Author(s):  
Giorgia Camperio ◽  
Caroline Welte ◽  
S. Nemiah Ladd ◽  
Matthew Prebble ◽  
Nathalie Dubois
Keyword(s):  
High Resolution ◽  
Radiocarbon Dating ◽  
Environmental Changes ◽  
Accumulation Rate ◽  
Sediment Cores ◽  
Volcanic Eruptions ◽  
High Accumulation ◽  
Sedimentary Records ◽  
The Pacific ◽  
Rapid Accumulation

<p>Espiritu Santo is one of the 82 islands of the archipelago of Vanuatu and is the largest, highest, and most biodiverse of the insular country. Climatic changes linked to El Niño and extreme events such as cyclones and volcanic eruptions are a daily challenge in this remote area. These events can be recorded in sedimentary archives. Here we present a multi-proxy investigation of sediment cores retrieved from two small lakes located on the West coast of Espiritu Santo. Although the records span the last millennium, high-resolution radiocarbon dating of macrofossils reveals a rapid accumulation of sediment in the past 100 years. The high accumulation rate coupled with the high-resolution dating of freshwater sediments allows us to compare the <sup>14</sup>C bomb curve with the biogeochemical proxies of the sedimentary records. The results can then be validated against written and oral historical records linked with the societal perception of recent environmental changes in this vulnerable ecosystem.</p><div> <div title="Translate selected text"></div> <div title="Play"></div> <div title="Copy text to Clipboard"></div> </div>

Geographical interpretation of measurements of average phase velocities of surface waves over great circular and great semi-circular paths

1964 ◽  
Vol 54 (2) ◽  
pp. 571-610
Author(s):  
George E. Backus
Keyword(s):  
Spherical Harmonics ◽  
Rayleigh Waves ◽  
Seismic Station ◽  
Great Circle ◽  
Explicit Formulas ◽  
Phase Velocities ◽  
Rapid Accumulation ◽  
Generalized Spherical Harmonics ◽  
Geographical Position ◽  
The Difference

ABSTRACT If the averages of the reciprocal phase velocity c−1 of a given Rayleigh or Love mode over various great circular or great semicircular paths are known, information can be extracted about how c−1 varies with geographical position. Assuming that geometrical optics is applicable, it is shown that if c−1 is isotropic its great circular averages determine only the sum of the values of c−1 at antipodal points and not their difference. The great semicircular averages determine the difference as well. If c−1 is anisotropic through any cause other than the earth's rotation, even great semicircular averages do not determine c−1 completely. Rotation has negligible effect on Love waves, and if it is the only anisotropy present its effect on Rayleigh waves can be measured and removed by comparing the averages of c−1 for the two directions of travel around any great circle not intersecting the poles of rotation. Only great circular and great semicircular paths are considered because every earthquake produces two averages of c−1 over such paths for each seismic station. No other paths permit such rapid accumulation of data when the azimuthal variations of the earthquakes' radiation patterns are unknown. Expansion of the data in generalized spherical harmonics circumvents the fact that the explicit formulas for c−1 in terms of its great circular or great semicircular integrals require differentiation of the data. Formulas are given for calculating the generalized spherical harmonics numerically.

scholarly journals A Potential of microRNAs for High-Content Screening

2011 ◽  
Vol 2011 ◽  
pp. 1-15 ◽  
Author(s):  
Andrius Serva ◽  
Christoph Claas ◽  
Vytaute Starkuviene
Keyword(s):  
Large Scale ◽  
Cellular Processes ◽  
Comprehensive Knowledge ◽  
Functional Models ◽  
Rapid Accumulation ◽  
Health And Disease ◽  
Temporal And Spatial ◽  
And Function ◽  
Functional Analyses ◽  
Immense Potential

In the last years miRNAs have increasingly been recognised as potent posttranscriptional regulators of gene expression. Possibly, miRNAs exert their action on virtually any biological process by simultaneous regulation of numerous genes. The importance of miRNA-based regulation in health and disease has inspired research to investigate diverse aspects of miRNA origin, biogenesis, and function. Despite the recent rapid accumulation of experimental data, and the emergence of functional models, the complexity of miRNA-based regulation is still far from being well understood. In particular, we lack comprehensive knowledge as to which cellular processes are regulated by which miRNAs, and, furthermore, how temporal and spatial interactions of miRNAs to their targets occur. Results from large-scale functional analyses have immense potential to address these questions. In this review, we discuss the latest progress in application of high-content and high-throughput functional analysis for the systematic elucidation of the biological roles of miRNAs.

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