Acceleration of ultrasonic tissue heating by microbubble agent

2008 ◽  
Vol 123 (5) ◽  
pp. 3215-3215 ◽  
Author(s):  
Shin‐Ichiro Umemura ◽  
Shin Yoshizawa ◽  
Kazuaki Sasaki ◽  
Ken‐Ichi Kawabata
Author(s):  
Simone Angela Winkler ◽  
Isabelle Saniour ◽  
Akshay Chaudhari ◽  
Fraser Robb ◽  
J Thomas Vaughan

2018 ◽  
Vol 128 (3) ◽  
pp. 875-884 ◽  
Author(s):  
Robert F. Dallapiazza ◽  
Kelsie F. Timbie ◽  
Stephen Holmberg ◽  
Jeremy Gatesman ◽  
M. Beatriz Lopes ◽  
...  

OBJECTIVEUltrasound can be precisely focused through the intact human skull to target deep regions of the brain for stereotactic ablations. Acoustic energy at much lower intensities is capable of both exciting and inhibiting neural tissues without causing tissue heating or damage. The objective of this study was to demonstrate the effects of low-intensity focused ultrasound (LIFU) for neuromodulation and selective mapping in the thalamus of a large-brain animal.METHODSTen Yorkshire swine (Sus scrofa domesticus) were used in this study. In the first neuromodulation experiment, the lemniscal sensory thalamus was stereotactically targeted with LIFU, and somatosensory evoked potentials (SSEPs) were monitored. In a second mapping experiment, the ventromedial and ventroposterolateral sensory thalamic nuclei were alternately targeted with LIFU, while both trigeminal and tibial evoked SSEPs were recorded. Temperature at the acoustic focus was assessed using MR thermography. At the end of the experiments, all tissues were assessed histologically for damage.RESULTSLIFU targeted to the ventroposterolateral thalamic nucleus suppressed SSEP amplitude to 71.6% ± 11.4% (mean ± SD) compared with baseline recordings. Second, we found a similar degree of inhibition with a high spatial resolution (∼ 2 mm) since adjacent thalamic nuclei could be selectively inhibited. The ventromedial thalamic nucleus could be inhibited without affecting the ventrolateral nucleus. During MR thermography imaging, there was no observed tissue heating during LIFU sonications and no histological evidence of tissue damage.CONCLUSIONSThese results suggest that LIFU can be safely used to modulate neuronal circuits in the central nervous system and that noninvasive brain mapping with focused ultrasound may be feasible in humans.


Author(s):  
Дина Владимировна Кривоносова ◽  
Евгений Сергеевич Ермолаев

На сегодняшний день в России для лечения варикозного расширения вен часто проводятся малоинвазивные операции методами радиочастотной или лазерной облитерации, при этом метод паровой облитерации при лечении варикозной болезни не применяется совсем. Однако метод паровой облитерации обладает существенными преимуществами: малый объём и биоинертность рабочей среды - водяного пара, его невысокая температура - 120 °С, исключающая вероятность образования нагара и перфорации венозной стенки. Целью данной работы является разработка математической модели для расчёта тепловых характеристик блока нагревания, входящего в устройство для лечения варикозной болезни методом паровой облитерации. Модель описывает теплообменные процессы в гидравлической трубке блока нагревания и может быть полезна при расчёте размеров нагревательного элемента, обеспечивающих нагрев и парообразование определённой порции воды. С целью верификации математической модели результаты моделирования были сопоставлены с экспериментальными данными. Была проведена серия экспериментов, в ходе которых были получены значения энергии, содержащейся в одной инжекции пара, и объём воды в одной инжекции, а также оценена фактическая тепловая мощность нагревателя. Сравнение результатов имитационного моделирования и значения фактической тепловой мощности пара, полученной экспериментальным путем, показала работоспособность математической модели. Разработанная математическая модель позволяет подбирать геометрические параметры нагревательного элемента в зависимости от требуемой тепловой мощности, которая должна быть обеспечена блоком нагревания, а также варьировать параметры нагревательного элемента для разной степени нагрева тканей Today in Russia minimally invasive varicose veins treatment is often performed using radiofrequency or laser ablation, while the method of steam ablation is not used at all. However, the steam ablation method has significant advantages: a small volume and biological inertness of the working substance - sterile water vapor, its low temperature - 120 °C, excluding the carbon deposits and perforation of the vein wall. The purpose of this work is to develop a mathematical model for calculating the thermal characteristics of the heating module as a part of the device for varicose veins treatment using steam ablation. The model describes heat exchange processes in the hydraulic circuit of the heating module and can be applied to calculate the dimensions of the heating module which provides heating and vaporization of a certain portion of water. In order to verify the mathematical model, the simulation results were compared with experimental data. A series of experiments were carried out in which the energy contained in one steam injection and the volume of water in one injection were estimated, as well as the actual thermal power of the heating module. Comparison of the results of simulation and the value of the actual thermal power of steam obtained experimentally showed the efficiency of the mathematical model. The proposed mathematical model allows to select the geometric parameters of the heating element depending on the required thermal power, which must be provided by the heating module, and also to vary the parameters of the heating element for different degrees of tissue heating


2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Maria Ida Iacono ◽  
Nikos Makris ◽  
Luca Mainardi ◽  
Leonardo M. Angelone ◽  
Giorgio Bonmassar

Deep brain stimulation (DBS) is an established procedure for the treatment of movement and affective disorders. Patients with DBS may benefit from magnetic resonance imaging (MRI) to evaluate injuries or comorbidities. However, the MRI radio-frequency (RF) energy may cause excessive tissue heating particularly near the electrode. This paper studies how the accuracy of numerical modeling of the RF field inside a DBS patient varies with spatial resolution and corresponding anatomical detail of the volume surrounding the electrodes. A multiscale model (MS) was created by an atlas-based segmentation using a 1 mm3head model (mRes) refined in the basal ganglia by a 200 μm2ex-vivo dataset. Four DBS electrodes targeting the left globus pallidus internus were modeled. Electromagnetic simulations at 128 MHz showed that the peak of the electric field of the MS doubled (18.7 kV/m versus 9.33 kV/m) and shifted 6.4 mm compared to the mRes model. Additionally, the MS had a sixfold increase over the mRes model in peak-specific absorption rate (SAR of 43.9 kW/kg versus 7 kW/kg). The results suggest that submillimetric resolution and improved anatomical detail in the model may increase the accuracy of computed electric field and local SAR around the tip of the implant.


2013 ◽  
Vol 58 (8) ◽  
pp. 2537-2559 ◽  
Author(s):  
Petr V Yuldashev ◽  
Svetlana M Shmeleva ◽  
Sergey A Ilyin ◽  
Oleg A Sapozhnikov ◽  
Leonid R Gavrilov ◽  
...  

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