scholarly journals An in-vivo investigation of the therapeutic effect of pulsed focused ultrasound on tumor growth

2014 ◽  
Vol 41 (12) ◽  
pp. 122901 ◽  
Author(s):  
C.-M. Ma ◽  
Xiaoming Chen ◽  
Dusica Cvetkovic ◽  
Lili Chen
Keyword(s):  
Tumor Growth ◽  
Therapeutic Effect ◽  
Focused Ultrasound ◽  
Pulsed Focused Ultrasound

Heating of tissues in vivo by pulsed focused ultrasound to stimulate enhanced HSP expression

2011 ◽  
Author(s):  
Tamara Kujawska ◽  
Janusz Wójcik ◽  
Andrzej Nowicki ◽  
Yoichiro Matsumoto ◽  
Lawrence A. Crum ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Pulsed Focused Ultrasound

Therapeutic effect of quantum dots for cancer treatment

RSC Advances ◽  
2016 ◽  
Vol 6 (114) ◽  
pp. 113791-113795 ◽  
Author(s):  
Mei-Xia Zhao ◽  
Bing-Jie Zhu ◽  
Wen-Jing Yao ◽  
Di-Feng Chen
Keyword(s):  
Quantum Dots ◽  
Tumor Growth ◽  
Cancer Treatment ◽  
Therapeutic Effect ◽  
Cell Apoptosis

The therapeutic effect of Qdots for cancer treatment arises from ROS-induced cell apoptosis and inhibited tumor growth in vivo.

scholarly journals The Nonthermal Therapeutic Effect of Pulsed Focused Ultrasound

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
C-M Charlie Ma ◽  
Xiaoming Chen ◽  
Alain Tafo ◽  
Dusica Cvetkovic ◽  
Lili Chen
Keyword(s):  
Therapeutic Effect ◽  
Focused Ultrasound ◽  
Pulsed Focused Ultrasound

scholarly journals MR Guided Pulsed High Intensity Focused Ultrasound Enhancement of Docetaxel Combined with Radiotherapy for Prostate Cancer Treatment

2018 ◽  
Author(s):  
Lili Chen ◽  
Alan Pollack
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Tumor Growth ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Tumor Growth Inhibition ◽  
Prostate Cancer Treatment ◽  
Ultrasound Enhancement ◽  
Enhance Tumor Growth

This project will determine whether (1) HIFU increases the cellular update of docetaxel in vivo, and (2) the increased uptake of docetaxel combined with RT will enhance tumor growth inhibition. We will determine the optimal HIFU parameters, quantify the update of docetaxel using a radioactive tritiated docetaxel and evaluate the efficacy of docetaxel+RT in inhibiting prostate tumor growth in vivo. This research has the potential to improve local control and may also have effects on distant microscopic disease by promoting immune response, which will also lay the foundation for other tumor models and studies on gene therapy and thrombolytic drugs.

scholarly journals Pulsed focused ultrasound enhances the therapeutic effect of mesenchymal stromal cell-derived extracellular vesicles in acute kidney injury

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Mujib Ullah ◽  
Daniel D. Liu ◽  
Sravanthi Rai ◽  
Mehdi Razavi ◽  
Waldo Concepcion ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Therapeutic Effect ◽  
Extracellular Vesicles ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Molecular Mechanisms ◽  
Focused Ultrasound ◽  
Combined Treatment ◽  
Kidney Injury ◽  
Pulsed Focused Ultrasound

Abstract Background Acute kidney injury (AKI) is characterized by rapid failure of renal function and has no curative therapies. Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) are known to carry therapeutic factors, which have shown promise in regenerative medicine applications, including AKI. However, there remains an unmet need to optimize their therapeutic effect. One potential avenue of optimization lies in pulsed focused ultrasound (pFUS), where tissues-of-interest are treated with sound waves. pFUS has been shown to enhance MSC therapy via increased cell homing, but its effects on cell-free EV therapy remain largely unexplored. Methods We combine pFUS pretreatment of the kidney with MSC-derived EV therapy in a mouse model of cisplatin-induced AKI. Results EVs significantly improved kidney function, reduced injury markers, mediated increased proliferation, and reduced inflammation and apoptosis. While pFUS did not enhance EV homing to the kidney, the combined treatment resulted in a superior therapeutic effect compared to either treatment alone. We identified several molecular mechanisms underlying this synergistic therapeutic effect, including upregulation of proliferative signaling (MAPK/ERK, PI3K/Akt) and regenerative pathways (eNOS, SIRT3), as well as suppression of inflammation. Conclusion Taken together, pFUS may be a strategy for enhancing the therapeutic efficacy of MSC-derived EV treatment for the treatment of AKI.

scholarly journals Integrin α10-Antibodies Reduce Glioblastoma Tumor Growth and Cell Migration

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1184
Author(s):  
Katarzyna Chmielarska Masoumi ◽  
Xiaoli Huang ◽  
Wondossen Sime ◽  
Anna Mirkov ◽  
Matilda Munksgaard Thorén ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Therapeutic Effect ◽  
Treatment Strategies ◽  
Immunohistochemical Analysis ◽  
Efficient Treatment ◽  
Blocking Antibody ◽  
Blocking Antibodies ◽  
Sphere Formation

Glioblastoma (GB) is the most common and the most aggressive form of brain tumor in adults, which currently lacks efficient treatment strategies. In this study, we investigated the therapeutic effect of function-blocking antibodies targeting integrin α10β1 on patient-derived-GB cell lines in vitro and in vivo. The in vitro studies demonstrated significant inhibiting effects of the integrin α10 antibodies on the adhesion, migration, proliferation, and sphere formation of GB cells. In a xenograft mouse model, the effect of the antibodies on tumor growth was investigated in luciferase-labeled and subcutaneously implanted GB cells. As demonstrated by in vivo imaging analysis and caliper measurements, the integrin α10-antibodies significantly suppressed GB tumor growth compared to control antibodies. Immunohistochemical analysis of the GB tumors showed lower expression of the proliferation marker Ki67 and an increased expression of cleaved caspase-3 after treatment with integrin α10 antibodies, further supporting a therapeutic effect. Our results suggest that function-blocking antibody targeting integrin α10β1 is a promising therapeutic strategy for the treatment of glioblastoma.

scholarly journals A New Nanomaterial Based on Extracellular Vesicles Containing Chrysin-Induced Cell Apoptosis Through Let-7a in Tongue Squamous Cell Carcinoma

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhijing Yang ◽  
Da Liu ◽  
Hengzong Zhou ◽  
Boqiang Tao ◽  
Lu Chang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Therapeutic Effect ◽  
Extracellular Vesicles ◽  
Squamous Cell ◽  
Cell Apoptosis ◽  
Tongue Squamous Cell Carcinoma ◽  
Apoptosis Pathway

Although the therapeutic strategy showed significant improvement, the therapeutic effect was poor on metastases in tongue squamous cell carcinoma (TSCC) which is the most malignant tumor found in the head and neck. Chrysin, similar to the flavonoids, plays an antitumor role by regulating the expression of ncRNAs in many kinds of cancers. Compared to flavonoids, gold nanoparticles (AuNPs) provide a novel insight into inhibiting cancer cell growth via photothermal therapy (PPT) which is irradiated by near-infrared radiation (NIR). However, most flavonoids and AuNPs lack specificity of tumor in vivo. The extracellular vesicles (EVs) which were abundant with ncRNAs are isolated from the cellular supernatant fluid and have the ability to carry drugs or nanoparticles to improve specificity. In the present study, we aimed to synthesize a new nanomaterial based on EVs containing chrysin and analyzed cell apoptosis in TSCC cells. Our results demonstrated that EVs-chrysin were isolated from SCC9 cells that were treated with chrysin. To improve the therapeutic effect, AuNPs were carried by EVs-chrysin (Au-EVs). Compared to BGC823 and HCC-LM3 cells, the uptake of Au-EVs was specific in SCC9 cells. Moreover, Au-EVs combined with NIR enhanced cell apoptosis in TSCC cells. To confirm the role of miRNAs in cell apoptosis, the differentially expressed miRNAs between EVs-Con and EVs-chrysin were screened by RNA-seq. The results revealed that the let-7a-3p family, which acts as the tumor suppressor, was upregulated in EVs-chrysin compared to EVs-Con. Thus, let-7a-3p was screened in the apoptosis pathway that was associated with the p53 protein. Furthermore, compared to the Con group, Au-EVs combined with the NIR group effectively inhibited tumor growth in vivo via increasing the expression of let-7a-3p. Together, as a new nanomaterial, Au-EVs induced cell apoptosis and inhibited tumor growth by regulating let-7a-3p expression in TSCC.

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