scholarly journals The Nonthermal Therapeutic Effect of Pulsed Focused Ultrasound

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
C-M Charlie Ma ◽  
Xiaoming Chen ◽  
Alain Tafo ◽  
Dusica Cvetkovic ◽  
Lili Chen
Keyword(s):  
Therapeutic Effect ◽  
Focused Ultrasound ◽  
Pulsed Focused Ultrasound

scholarly journals Pulsed focused ultrasound enhances the therapeutic effect of mesenchymal stromal cell-derived extracellular vesicles in acute kidney injury

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Mujib Ullah ◽  
Daniel D. Liu ◽  
Sravanthi Rai ◽  
Mehdi Razavi ◽  
Waldo Concepcion ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Therapeutic Effect ◽  
Extracellular Vesicles ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Molecular Mechanisms ◽  
Focused Ultrasound ◽  
Combined Treatment ◽  
Kidney Injury ◽  
Pulsed Focused Ultrasound

Abstract Background Acute kidney injury (AKI) is characterized by rapid failure of renal function and has no curative therapies. Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) are known to carry therapeutic factors, which have shown promise in regenerative medicine applications, including AKI. However, there remains an unmet need to optimize their therapeutic effect. One potential avenue of optimization lies in pulsed focused ultrasound (pFUS), where tissues-of-interest are treated with sound waves. pFUS has been shown to enhance MSC therapy via increased cell homing, but its effects on cell-free EV therapy remain largely unexplored. Methods We combine pFUS pretreatment of the kidney with MSC-derived EV therapy in a mouse model of cisplatin-induced AKI. Results EVs significantly improved kidney function, reduced injury markers, mediated increased proliferation, and reduced inflammation and apoptosis. While pFUS did not enhance EV homing to the kidney, the combined treatment resulted in a superior therapeutic effect compared to either treatment alone. We identified several molecular mechanisms underlying this synergistic therapeutic effect, including upregulation of proliferative signaling (MAPK/ERK, PI3K/Akt) and regenerative pathways (eNOS, SIRT3), as well as suppression of inflammation. Conclusion Taken together, pFUS may be a strategy for enhancing the therapeutic efficacy of MSC-derived EV treatment for the treatment of AKI.

scholarly journals An in-vivo investigation of the therapeutic effect of pulsed focused ultrasound on tumor growth

2014 ◽  
Vol 41 (12) ◽  
pp. 122901 ◽  
Author(s):  
C.-M. Ma ◽  
Xiaoming Chen ◽  
Dusica Cvetkovic ◽  
Lili Chen
Keyword(s):  
Tumor Growth ◽  
Therapeutic Effect ◽  
Focused Ultrasound ◽  
Pulsed Focused Ultrasound

IR780 loaded perfluorohexane nanodroplets for efficient sonodynamic effect induced by short-pulsed focused ultrasound

2019 ◽  
Vol 53 ◽  
pp. 59-67 ◽  
Author(s):  
Nan Chang ◽  
Dui Qin ◽  
Pengying Wu ◽  
Shanshan Xu ◽  
Supin Wang ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Pulsed Focused Ultrasound

Cancer treatment using an optically inert Rose Bengal derivative combined with pulsed focused ultrasound

2012 ◽  
Author(s):  
Yoo-Shin Kim ◽  
Valentina Rubio ◽  
Jianjun Qi ◽  
Rongmin Xia ◽  
Zheng-Zheng Shi ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Rose Bengal ◽  
Focused Ultrasound ◽  
Pulsed Focused Ultrasound
Sign in / Sign up

Export Citation Format

Share Document