SU-D-144-03: Respiratory Motion Management for High-Precision Small Animal Irradiation

2013 ◽  
Vol 40 (6Part4) ◽  
pp. 116-116 ◽  
Author(s):  
A Rubinstein ◽  
J Yang ◽  
R Martin ◽  
C Kingsley ◽  
J Delacerda ◽  
...  
Keyword(s):  
High Precision ◽  
Respiratory Motion ◽  
Small Animal ◽  
Motion Management

Use of the Leksell Gamma Knife for Localized Small Field Lens Irradiation in Rodents

2003 ◽  
Vol 2 (5) ◽  
pp. 449-454 ◽  
Author(s):  
Colleen DesRosiers ◽  
Marc S. Mendonca ◽  
Craig Tyree ◽  
Vadim Moskvin ◽  
Morris Bank ◽  
...  
Keyword(s):  
Gamma Knife ◽  
High Precision ◽  
Small Animal ◽  
Small Animals ◽  
Small Field ◽  
Thermoluminescent Dosimeters ◽  
Ion Chamber ◽  
Order Of Magnitude ◽  
Contralateral Eye

For most basic radiobiological research applications involving irradiation of small animals, it is difficult to achieve the same high precision dose distribution realized with human radiotherapy. The precision for irradiations performed with standard radiotherapy equipment is ±2 mm in each dimension, and is adequate for most human treatment applications. For small animals such as rodents, whose organs and tissue structures may be an order of magnitude smaller than those of humans, the corresponding precision required is closer to ±0.2 mm, if comparisons or extrapolations are to be made to human data. The Leksell Gamma Knife is a high precision radiosurgery irradiator, with precision in each dimension not exceeding 0.5 mm, and overall precision of 0.7 mm. It has recently been utilized to treat ocular melanoma and induce targeted lesions in the brains of small animals. This paper describes the dosimetry and a technique for performing irradiation of a single rat eye and lens with the Gamma Knife while allowing the contralateral eye and lens of the same rat to serve as the “control”. The dosimetry was performed with a phantom in vitro utilizing a pinpoint ion chamber and thermoluminescent dosimeters, and verified by Monte Carlo simulations. We found that the contralateral eye received less than 5% of the administered dose for a 15 Gy exposure to the targeted eye. In addition, after 15 Gy irradiation 15 out of 16 animals developed cataracts in the irradiated target eyes, while 0 out of 16 contralateral eyes developed cataracts over a 6-month period of observation. Experiments at 5 and 10 Gy also confirmed the lack of cataractogenesis in the contralateral eye. Our results validate the use of the Gamma Knife for cataract studies in rodents, and confirmed the precision and utility of the instrument as a small animal irradiator for translational radiobiology experiments.

Simultaneous respiratory motion correction and image reconstruction in 4D‐multi pinhole small animal SPECT

2019 ◽  
Vol 46 (11) ◽  
pp. 5047-5054 ◽  
Author(s):  
Maryam Naseri ◽  
Hossein Rajabi ◽  
Jing Wang ◽  
Mehrshad Abbasi ◽  
Faraz Kalantari
Keyword(s):  
Image Reconstruction ◽  
Motion Correction ◽  
Respiratory Motion ◽  
Small Animal ◽  
Respiratory Motion Correction

scholarly journals Audio-Visual Biofeedback for Respiratory Motion Management: Comparison of the Reproducibility of Breath-Holding between Visual and Audio Guidance

2018 ◽  
Vol 09 (13) ◽  
pp. 2286-2294
Author(s):  
Naoki Sano ◽  
Masahide Saito ◽  
Hiroshi Onishi ◽  
Kengo Kuriyama ◽  
Takafumi Komiyama ◽  
...  
Keyword(s):  
Respiratory Motion ◽  
Breath Holding ◽  
Motion Management ◽  
Visual Biofeedback

Quasi-breath-hold technique using personalized audio-visual biofeedback for respiratory motion management in radiotherapy

2011 ◽  
Vol 38 (6Part1) ◽  
pp. 3114-3124 ◽  
Author(s):  
Yang-Kyun Park ◽  
Siyong Kim ◽  
Hwiyoung Kim ◽  
II Han Kim ◽  
Kunwoo Lee ◽  
...  
Keyword(s):  
Respiratory Motion ◽  
Breath Hold ◽  
Motion Management ◽  
Visual Biofeedback

Evaluation and reduction of respiratory motion artifacts in small animal SPECT with GATE

2015 ◽  
Vol 10 (09) ◽  
pp. T09003-T09003
Author(s):  
C.-L. Lee ◽  
S.-J. Park ◽  
H.-J. Kim
Keyword(s):  
Respiratory Motion ◽  
Small Animal ◽  
Motion Artifacts
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