Porous Phantoms Mimicking Tissues—Investigation of Optical Parameters Stability Over Time

Optical phantoms are used to validate optical measurement methods. The stability of their optical parameters over time allows them to be used and stored over long-term periods, while maintaining their optical parameters. The aim of the presented research was to investigate the stability of fabricated porous phantoms, which can be used as a lung phantom in optical system. Measurements were performed in multiple series with an interval of 6 months, recreating the same conditions and using the same measuring system consisting of an integrating sphere, a coherent light source with a wavelength of 635 nm and a detector. Scattering and absorption parameters were determined on the basis of the measured reflectance and transmittance. The tested samples were made of silicone and glycerol in various proportions.

Respiration parameter determination with non-obstructive methods

Measuring respiratory parameters like the breathing frequency or the tidal volume is essential in intensive care to ensure an optimal and lung protecting ventilation. A common practice in artificial ventilation of sensitive patients like infants or neonates is the use of uncuffed endotracheal tubes in combination with continuous positive airway pressure (CPAP). This comes with the disadvantage of an unknown leakage making it difficult to detect spontaneous breathing or to measure the tidal volume reliable. A novel non-obstructive method to determine respiratory parameters as well as dynamic changes of thoracic parameters has recently been presented and uses a pair of coupled UHF (ultra high frequency) antennae. In this paper, a respective setup is investigated numerically using finite difference time domain method and experimentally using an artificial lung phantom. Both approaches show that the investigated method seems capable of allowing a contactless triggering to synchronize natural and artificial breathing. The results are compared to derive a better understanding of influencing factors and opportunities for an optimisation.

Image quality of 4D in-treatment CBCT acquired during lung SBRT using FFF beam: a phantom study

Background Rotational beam delivery enables concurrent acquisition of cone-beam CT (CBCT), thereby facilitating further geometric verification of patient setup during radiation treatment. However, it is challenging to acquire CBCT during stereotactic body radiation therapy (SBRT) using flattening-filter free X-ray beams, in which a high radiation dose is delivered. This study presents quantitative evaluation results of the image quality in four-dimensional (4D) in-treatment CBCT acquired during SBRT delivery. Methods The impact of megavoltage (MV) scatter and acquisition parameters on the image quality was evaluated using Catphan 503 and XSight lung tracking phantoms. The in-treatment CBCT images of the phantoms were acquired while delivering 16 SBRT plans. The uniformity, contrast, and contrast-to-noise ratio (CNR) of the in-treatment CBCT images were calculated and compared to those of CBCT images acquired without SBRT delivery. Furthermore, the localizing accuracy of the moving target in the XSight lung phantom was evaluated for 10 respiratory phases. Results The CNR of the 3D-reconstucted Catphan CBCT images was reduced from 6.3 to 2.6 due to the effect of MV treatment scatter. Both for the Catphan and XSight phantoms, the CBCT image quality was affected by the tube current and monitor units (MUs) of the treatment plan. The lung target in the XSight tracking phantom was most visible for extreme phases; the mean CNRs of the lung target in the in-treatment CBCT images (with 40 mA tube current) across the SBRT plans were 3.2 for the end-of-exhalation phase and 3.0 for the end-of-inhalation phase. The lung target was localized with sub-millimeter accuracy for the extreme respiratory phases. Conclusions Full-arc acquisition with an increased tube current (e.g. 40 mA) is recommended to compensate for degradation in the CBCT image quality due to unflattened MV beam scatter. Acquiring in-treatment CBCT with a high-MU treatment beam is also suggested to improve the resulting CBCT image quality.