Computer- and robot-assisted stereotaxy for high-precision small animal brain exploration / Computer- und robotergestützte Stereotaxie für hochpräzise Exploration des Kleintierhirns

2009 ◽  
Vol 54 (1) ◽  
pp. 8-13 ◽  
Author(s):  
Lukas Ramrath ◽  
Simon Vogt ◽  
Winnie Jensen ◽  
Ulrich G. Hofmann ◽  
Achim Schweikard
Keyword(s):  
High Precision ◽  
Small Animal ◽  
Robot Assisted ◽  
Animal Brain

scholarly journals An Optimized Registration Workflow and Standard Geometric Space for Small Animal Brain Imaging

NeuroImage ◽  
2021 ◽  
pp. 118386
Author(s):  
Horea-Ioan Ioanas ◽  
Markus Marks ◽  
Valerio Zerbi ◽  
Mehmet Fatih Yanik ◽  
Markus Rudin
Keyword(s):  
Brain Imaging ◽  
Small Animal ◽  
Animal Brain ◽  
Geometric Space

Use of the Leksell Gamma Knife for Localized Small Field Lens Irradiation in Rodents

2003 ◽  
Vol 2 (5) ◽  
pp. 449-454 ◽  
Author(s):  
Colleen DesRosiers ◽  
Marc S. Mendonca ◽  
Craig Tyree ◽  
Vadim Moskvin ◽  
Morris Bank ◽  
...  
Keyword(s):  
Gamma Knife ◽  
High Precision ◽  
Small Animal ◽  
Small Animals ◽  
Small Field ◽  
Thermoluminescent Dosimeters ◽  
Ion Chamber ◽  
Order Of Magnitude ◽  
Contralateral Eye

For most basic radiobiological research applications involving irradiation of small animals, it is difficult to achieve the same high precision dose distribution realized with human radiotherapy. The precision for irradiations performed with standard radiotherapy equipment is ±2 mm in each dimension, and is adequate for most human treatment applications. For small animals such as rodents, whose organs and tissue structures may be an order of magnitude smaller than those of humans, the corresponding precision required is closer to ±0.2 mm, if comparisons or extrapolations are to be made to human data. The Leksell Gamma Knife is a high precision radiosurgery irradiator, with precision in each dimension not exceeding 0.5 mm, and overall precision of 0.7 mm. It has recently been utilized to treat ocular melanoma and induce targeted lesions in the brains of small animals. This paper describes the dosimetry and a technique for performing irradiation of a single rat eye and lens with the Gamma Knife while allowing the contralateral eye and lens of the same rat to serve as the “control”. The dosimetry was performed with a phantom in vitro utilizing a pinpoint ion chamber and thermoluminescent dosimeters, and verified by Monte Carlo simulations. We found that the contralateral eye received less than 5% of the administered dose for a 15 Gy exposure to the targeted eye. In addition, after 15 Gy irradiation 15 out of 16 animals developed cataracts in the irradiated target eyes, while 0 out of 16 contralateral eyes developed cataracts over a 6-month period of observation. Experiments at 5 and 10 Gy also confirmed the lack of cataractogenesis in the contralateral eye. Our results validate the use of the Gamma Knife for cataract studies in rodents, and confirmed the precision and utility of the instrument as a small animal irradiator for translational radiobiology experiments.

scholarly journals Optimising rigid motion compensation for small animal brain PET imaging

2016 ◽  
Vol 61 (19) ◽  
pp. 7074-7091 ◽  
Author(s):  
Matthew G Spangler-Bickell ◽  
Lin Zhou ◽  
Andre Z Kyme ◽  
Bart De Laat ◽  
Roger R Fulton ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Motion Compensation ◽  
Rigid Motion ◽  
Small Animal ◽  
Animal Brain ◽  
Brain Pet

SU-D-144-03: Respiratory Motion Management for High-Precision Small Animal Irradiation

2013 ◽  
Vol 40 (6Part4) ◽  
pp. 116-116 ◽  
Author(s):  
A Rubinstein ◽  
J Yang ◽  
R Martin ◽  
C Kingsley ◽  
J Delacerda ◽  
...  
Keyword(s):  
High Precision ◽  
Respiratory Motion ◽  
Small Animal ◽  
Motion Management

Real-time 3D motion tracking for small animal brain PET

2008 ◽  
Vol 53 (10) ◽  
pp. 2651-2666 ◽  
Author(s):  
A Z Kyme ◽  
V W Zhou ◽  
S R Meikle ◽  
R R Fulton
Keyword(s):  
Real Time ◽  
Motion Tracking ◽  
Small Animal ◽  
3D Motion ◽  
Animal Brain ◽  
Brain Pet

Volumetric Doppler imaging of small animal brain using spectral and time domain optical coherence tomography

2011 ◽  
Author(s):  
Danuta Bukowska ◽  
Ireneusz Grulkowski ◽  
Grzegorz Wilczynski ◽  
Szymon Tamborski ◽  
Daniel Ruminski ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Time Domain ◽  
Small Animal ◽  
Doppler Imaging ◽  
Optical Coherence ◽  
Animal Brain

scholarly journals High-density speckle contrast optical tomography (SCOT) for three dimensional tomographic imaging of the small animal brain

NeuroImage ◽  
2017 ◽  
Vol 153 ◽  
pp. 283-292 ◽  
Author(s):  
Tanja Dragojević ◽  
Hari M. Varma ◽  
Joseph L. Hollmann ◽  
Claudia P. Valdes ◽  
Joseph P. Culver ◽  
...  
Keyword(s):  
Optical Tomography ◽  
Three Dimensional ◽  
Small Animal ◽  
Tomographic Imaging ◽  
High Density ◽  
Speckle Contrast ◽  
Animal Brain
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