Quantitative Characterization Of Tumors And Other Lesions In VIVO Using Ultrasonic Impediography

Author(s):  
Joie P. Jones
Author(s):  
Patrick Ho ◽  
Hyunglae Lee ◽  
Mohammad A. Rastgaar ◽  
Hermano Igo Krebs ◽  
Neville Hogan

This article presents the results of two in-vivo studies providing measurements of human static ankle mechanical impedance. Accurate measurements of ankle impedance when muscles were voluntarily activated were obtained using a therapeutic robot, Anklebot, and an electromyographic recording system. Important features of ankle impedance, and their variation with muscle activity, are discussed, including magnitude, symmetry and directions of minimum and maximum impedance. Voluntary muscle activation has a significant impact on ankle impedance, increasing it by up to a factor of three in our experiments. Furthermore, significant asymmetries and deviations from a linear two-spring model are present in many subjects, indicating that ankle impedance has a complex and individually idiosyncratic structure. We propose the use of Fourier series as a general representation, providing both insight and a precise quantitative characterization of human static ankle impedance.


2012 ◽  
Vol 2012 ◽  
pp. 1-7
Author(s):  
A. Kavaguchi De Grandis ◽  
C. Boulocher ◽  
E. Viguier ◽  
T. Roger ◽  
S. Sawaya

A tendinopathy is a clinical condition characterized by activity-related pain, focal tendons tenderness, and intratendinous imaging changes. This study characterizes a surgically induced tendinopathy in a goat model with a noninvasivein vivolongitudinal followup based on physical examination and US. Cross-sectional area (CSA) is the most objective feature for the evaluation of tendinopathy in correlation with clinical findings. The deep digital flexor tendon (DDFT) of the left hind limb of six goats was isolated and scarified by a modified splitting. Pain and lameness at walk and trot were evaluated. External width and thickness of tendon region were measured by calipers. CSA and the ratio lesion/tendon CSA were obtained at days 0, 7, 21, 42, and 84 by US. The highest value of global functional score was obtained at day 7, then decreased until day 40 and was not significantly different from day 0 at the end of the study. The external width recovered a normal value at the end of the study, but the external thickness was still significantly increased (P<0.05). Peritendinous oedema was observed at day 7, but intratendinous lesions were visible only at day 21 as a focal hypo to anechoic area. At day 84, two tendons still presented visible lesions. US examination was reproducible, specific, and provided complementary information to the global functional score. A standardized focal tendinopathy was induced in goats. This experimental model of focal tendinopathy could be used to study the effect of different treatments.


2006 ◽  
Vol 357 (4) ◽  
pp. 1253-1262 ◽  
Author(s):  
Lynette Cegelski ◽  
Dirk Steuber ◽  
Anil K. Mehta ◽  
Daniel W. Kulp ◽  
Paul H. Axelsen ◽  
...  

2017 ◽  
Vol 22 (3) ◽  
pp. 034001 ◽  
Author(s):  
Pin-Chieh Huang ◽  
Paritosh Pande ◽  
Ryan L. Shelton ◽  
Frank Joa ◽  
Dave Moore ◽  
...  

2012 ◽  
Vol 156 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Ibrahim Aboshady ◽  
Dianna D. Cody ◽  
Evan M. Johnson ◽  
Amir Gahremanpour ◽  
Deborah Vela ◽  
...  

2020 ◽  
Vol 477 (7) ◽  
pp. 1261-1286 ◽  
Author(s):  
Marie Anne Richard ◽  
Hannah Pallubinsky ◽  
Denis P. Blondin

Brown adipose tissue (BAT) has long been described according to its histological features as a multilocular, lipid-containing tissue, light brown in color, that is also responsive to the cold and found especially in hibernating mammals and human infants. Its presence in both hibernators and human infants, combined with its function as a heat-generating organ, raised many questions about its role in humans. Early characterizations of the tissue in humans focused on its progressive atrophy with age and its apparent importance for cold-exposed workers. However, the use of positron emission tomography (PET) with the glucose tracer [18F]fluorodeoxyglucose ([18F]FDG) made it possible to begin characterizing the possible function of BAT in adult humans, and whether it could play a role in the prevention or treatment of obesity and type 2 diabetes (T2D). This review focuses on the in vivo functional characterization of human BAT, the methodological approaches applied to examine these features and addresses critical gaps that remain in moving the field forward. Specifically, we describe the anatomical and biomolecular features of human BAT, the modalities and applications of non-invasive tools such as PET and magnetic resonance imaging coupled with spectroscopy (MRI/MRS) to study BAT morphology and function in vivo, and finally describe the functional characteristics of human BAT that have only been possible through the development and application of such tools.


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