Quantitative characterization of the progression of focal brain ischemia in a rat photochemical stroke model using in-vivo MRI

2000 ◽  
Author(s):  
Anne-Marie Van der Linden ◽  
Marleen Verhoye ◽  
M. De Ryck
Author(s):  
Patrick Ho ◽  
Hyunglae Lee ◽  
Mohammad A. Rastgaar ◽  
Hermano Igo Krebs ◽  
Neville Hogan

This article presents the results of two in-vivo studies providing measurements of human static ankle mechanical impedance. Accurate measurements of ankle impedance when muscles were voluntarily activated were obtained using a therapeutic robot, Anklebot, and an electromyographic recording system. Important features of ankle impedance, and their variation with muscle activity, are discussed, including magnitude, symmetry and directions of minimum and maximum impedance. Voluntary muscle activation has a significant impact on ankle impedance, increasing it by up to a factor of three in our experiments. Furthermore, significant asymmetries and deviations from a linear two-spring model are present in many subjects, indicating that ankle impedance has a complex and individually idiosyncratic structure. We propose the use of Fourier series as a general representation, providing both insight and a precise quantitative characterization of human static ankle impedance.


2012 ◽  
Vol 2012 ◽  
pp. 1-7
Author(s):  
A. Kavaguchi De Grandis ◽  
C. Boulocher ◽  
E. Viguier ◽  
T. Roger ◽  
S. Sawaya

A tendinopathy is a clinical condition characterized by activity-related pain, focal tendons tenderness, and intratendinous imaging changes. This study characterizes a surgically induced tendinopathy in a goat model with a noninvasivein vivolongitudinal followup based on physical examination and US. Cross-sectional area (CSA) is the most objective feature for the evaluation of tendinopathy in correlation with clinical findings. The deep digital flexor tendon (DDFT) of the left hind limb of six goats was isolated and scarified by a modified splitting. Pain and lameness at walk and trot were evaluated. External width and thickness of tendon region were measured by calipers. CSA and the ratio lesion/tendon CSA were obtained at days 0, 7, 21, 42, and 84 by US. The highest value of global functional score was obtained at day 7, then decreased until day 40 and was not significantly different from day 0 at the end of the study. The external width recovered a normal value at the end of the study, but the external thickness was still significantly increased (P<0.05). Peritendinous oedema was observed at day 7, but intratendinous lesions were visible only at day 21 as a focal hypo to anechoic area. At day 84, two tendons still presented visible lesions. US examination was reproducible, specific, and provided complementary information to the global functional score. A standardized focal tendinopathy was induced in goats. This experimental model of focal tendinopathy could be used to study the effect of different treatments.


2006 ◽  
Vol 357 (4) ◽  
pp. 1253-1262 ◽  
Author(s):  
Lynette Cegelski ◽  
Dirk Steuber ◽  
Anil K. Mehta ◽  
Daniel W. Kulp ◽  
Paul H. Axelsen ◽  
...  

2017 ◽  
Vol 22 (3) ◽  
pp. 034001 ◽  
Author(s):  
Pin-Chieh Huang ◽  
Paritosh Pande ◽  
Ryan L. Shelton ◽  
Frank Joa ◽  
Dave Moore ◽  
...  

2012 ◽  
Vol 156 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Ibrahim Aboshady ◽  
Dianna D. Cody ◽  
Evan M. Johnson ◽  
Amir Gahremanpour ◽  
Deborah Vela ◽  
...  

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