Preliminary investigations of rat skin after topical application of optical clearing agent

2010 ◽  
Author(s):  
Jing Wang ◽  
Dan Zhu
Keyword(s):  
Topical Application ◽  
Rat Skin ◽  
Optical Clearing

Kinetics of Rat Skin Optical Clearing at Topical Application of 40%Glucose: Ex Vivo and In Vivo Studies

2019 ◽  
Vol 25 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Daria K. Tuchina ◽  
Polina A. Timoshina ◽  
Valery V. Tuchin ◽  
Alexey N. Bashkatov ◽  
Elina A. Genina
Keyword(s):  
Topical Application ◽  
Ex Vivo ◽  
Rat Skin ◽  
Optical Clearing ◽  
Kinetics Of

Gel-based Microemulsion Design and Evaluation for Topical Application of Rivastigmine

2020 ◽  
Vol 21 (4) ◽  
pp. 298-304
Author(s):  
Chih-Wen Fang ◽  
Ling-Chun Tsai ◽  
Yaw-Syan Fu ◽  
Ting-Yu Cheng ◽  
Pao-Chu Wu
Keyword(s):  
Topical Application ◽  
Skin Irritation ◽  
Topical Administration ◽  
Lag Time ◽  
Enhancement Effect ◽  
Microemulsion Formulation ◽  
Rat Skin ◽  
Glycol Monobutyl Ether ◽  
Loading Amount ◽  
Hydrophilic Gel

Objective: The aim of the present study was to design nanocarriers for the topical application of rivastigmine. Methods: The effect of cosurfactants, hydrophilic gel and loading amount on the permeability of rivastigmine through rat skin was evaluated. Skin irritation tests and stability tests were performed to evaluate the utility of tested formulations. Results: The results showed that the microemulsion formation and characteristics of drug-loaded formulations were related to many parameters of the components. When using microemulsion systems as a vehicle, the permeation rate remarkably increased about 13.2~24.3-fold and the lag time was significantly shortened from 24 h to 4.7 h. Formulations containing a cosurfactant of Diethylene Glycol Monobutyl Ether (DEGBE) showed higher enhancement effect, while increasing the loading dose from 0.5% to 5% further increased the flux about 2.1-fold and shortened the lag time. Conclusion: The drug-loaded experimental formulation did not cause skin irritation and had good stability at 20ºC and 40ºC storage for at least 3 months. The result showed that gel-based microemulsion formulation could be a promising approach for topical administration.

scholarly journals The metabolic transformations of columbinic acid and the effect of topical application of the major metabolites on rat skin.

1985 ◽  
Vol 260 (2) ◽  
pp. 987-992
Author(s):  
W J Elliott ◽  
A R Morrison ◽  
H W Sprecher ◽  
P Needleman
Keyword(s):  
Topical Application ◽  
Rat Skin

Enhanced optical clearing of human skin at topical application of immersion agents to stratum corneum pretreated by a lattice-like photothermal ablation

2006 ◽  
Author(s):  
Valery V. Tuchin ◽  
Gregory B. Altshuler ◽  
Anna A. Gavrilova ◽  
Alexander B. Pravdin ◽  
David Tabatadze ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Topical Application ◽  
Optical Clearing ◽  
Photothermal Ablation

Estradiol distribution and penetration in rat skin after topical application, studied by high resolution autoradiography

1990 ◽  
Vol 95 (1) ◽  
pp. 43-54 ◽  
Author(s):  
H. J. Bidmon ◽  
J. D. Pitts ◽  
H. F. Solomon ◽  
J. V. Bondi ◽  
W. E. Stumpf
Keyword(s):  
High Resolution ◽  
Topical Application ◽  
Rat Skin ◽  
High Resolution Autoradiography
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