Investigation on dynamic optical clearing effect of skin tissue under topical application of hyperosmotic agents studied with FT-IR imaging as an analytical tool

2006 ◽  
Author(s):  
J. Jiang ◽  
M. Boese ◽  
P. Tunner ◽  
R. K. Wang
Keyword(s):  
Topical Application ◽  
Analytical Tool ◽  
Skin Tissue ◽  
Optical Clearing ◽  
Ir Imaging ◽  
Ft Ir

The use of FT-IR imaging as an analytical tool for the characterization of drug delivery systems

2003 ◽  
Vol 93 (3) ◽  
pp. 223-248 ◽  
Author(s):  
Carrie A Coutts-Lendon ◽  
Norman A Wright ◽  
Ellen V Mieso ◽  
Jack L Koenig
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Analytical Tool ◽  
Ir Imaging ◽  
Ft Ir

The role of melatonin on zebrafish follicle development: An FT-IR imaging approach

2012 ◽  
Vol 62 ◽  
pp. 279-285 ◽  
Author(s):  
Elisabetta Giorgini ◽  
Giorgia Gioacchini ◽  
Carla Conti ◽  
Paolo Ferraris ◽  
Simona Sabbatini ◽  
...  
Keyword(s):  
Follicle Development ◽  
Ir Imaging ◽  
Imaging Approach ◽  
Ft Ir

Quantification of plaque area and characterization of plaque biochemical composition with atherosclerosis progression in ApoE/LDLR−/− mice by FT-IR imaging

The Analyst ◽  
2013 ◽  
Vol 138 (21) ◽  
pp. 6645 ◽  
Author(s):  
Tomasz P. Wrobel ◽  
Lukasz Mateuszuk ◽  
Renata B. Kostogrys ◽  
Stefan Chlopicki ◽  
Malgorzata Baranska
Keyword(s):  
Biochemical Composition ◽  
Atherosclerosis Progression ◽  
Plaque Area ◽  
Ir Imaging ◽  
Ft Ir

Contribution of ATR/FT-IR Spectroscopy for Studying the in vivo Behavior of Octylmethoxycinnamate (OMC) after Topical Application

2001 ◽  
Vol 55 (9) ◽  
pp. 1173-1180 ◽  
Author(s):  
C. Laugel ◽  
C. Do Nascimento ◽  
D. Ferrier ◽  
J. P. Marty ◽  
A. Baillet
Keyword(s):  
Ir Spectroscopy ◽  
Topical Application ◽  
Ft Ir ◽  
Ft Ir Spectroscopy

EXPRESS: On the Limit of Detection in Infrared Spectroscopic Imaging

2021 ◽  
pp. 000370282110509
Author(s):  
Laurin Lux ◽  
Yamuna Dilip Phal ◽  
Pei-Hsuan Hsieh ◽  
Rohit Bhargava
Keyword(s):  
Limit Of Detection ◽  
Protein Microarray ◽  
Spectroscopic Imaging ◽  
Single Frequency ◽  
Systematic Analysis ◽  
Protein Mass ◽  
Ir Imaging ◽  
Wide Range ◽  
Ft Ir ◽  
Processing Techniques

Infrared (IR) spectroscopic imaging instruments’ performance can be characterized and optimized by an analysis of their limit of detection (LoD). Here we report a systematic analysis of the LoD for Fourier transform IR (FT-IR) and discrete frequency IR (DFIR) imaging spectrometers. In addition to traditional measurements of sample and blank data, we propose a decision theory perspective to pose the determination of LoD as a binary classification problem under different assumptions of noise uniformity and correlation. We also examine three spectral analysis approaches, namely absorbance at a single frequency, sum of absorbance over selected frequencies and total spectral distance – to suit instruments that acquire discrete or contiguous spectral bandwidths. The analysis is validated by refining the fabrication of a bovine serum albumin protein microarray to provide eight uniform spots from 2.8 nL of solution for each concentration over a wide range (0.05 -10 mg/mL). Using scanning parameters that are typical for each instrument, we estimate a LoD of 0.16 mg/mL and 0.12 mg/mL for widefield and line scanning FT-IR imaging systems, respectively, usingthespectraldistanceapproach,and0.22mg/mLand0.15mg/mL using an optimal set of discrete frequencies. As expected, averaging and the use of post-processing techniques such as minimum noise fraction (MNF) transformation results in LoDs as low as 0.075 mg/mL that correspond to a spotted protein mass of 112 fg/pixel. We emphasize that these measurements were conducted at typical imaging parameters for each instrument and can be improved using the usual trading rules of IR spectroscopy. This systematic analysis and methodology for determining the LoD can allow for quantitative measures of confidence in imaging an analyte’s concentration and a basis for further improving IR imaging technology.

Enhanced optical clearing of human skin at topical application of immersion agents to stratum corneum pretreated by a lattice-like photothermal ablation

2006 ◽  
Author(s):  
Valery V. Tuchin ◽  
Gregory B. Altshuler ◽  
Anna A. Gavrilova ◽  
Alexander B. Pravdin ◽  
David Tabatadze ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Topical Application ◽  
Optical Clearing ◽  
Photothermal Ablation

scholarly journals Author Correction: Comparison of spectral and spatial denoising techniques in the context of High Definition FT-IR imaging hyperspectral data

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Paulina Koziol ◽  
Magda K. Raczkowska ◽  
Justyna Skibinska ◽  
Sławka Urbaniak-Wasik ◽  
Czesława Paluszkiewicz ◽  
...  
Keyword(s):  
Hyperspectral Data ◽  
High Definition ◽  
Ir Imaging ◽  
Ft Ir

Influence of interference effects on the spectral quality and histological classification by FT-IR imaging in transflection geometry

The Analyst ◽  
2021 ◽  
Author(s):  
Danuta Liberda ◽  
Paulina Koziol ◽  
Magda K. Raczkowska ◽  
Wojciech M. Kwiatek ◽  
Tomasz P. Wrobel
Keyword(s):  
Machine Learning ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Histological Classification ◽  
Spectral Quality ◽  
Interference Effects ◽  
Ir Imaging ◽  
Ft Ir ◽  
Non Destructive

Infrared (IR) imaging can be used for fast, accurate and non-destructive pathology recognition of biopsies when supported by machine learning algorithms regardless of the presence of interference effects obscuring the spectra.

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