Influence of vesicle size distribution on level and selectivity of accumulation of liposomal photosensitizer Tiosens in tumor

2007 ◽  
Author(s):  
Gennady A. Meerovich ◽  
Igor G. Meerovich ◽  
Daria G. Gurevich ◽  
Sergey I. Vorobyov ◽  
Vyacheslav G. Pevgov ◽  
...  
Keyword(s):  
Size Distribution ◽  
Vesicle Size ◽  
Vesicle Size Distribution

scholarly journals Enthalpic incompatibility between two steric stabilizer blocks provides control over the vesicle size distribution during polymerization-induced self-assembly in aqueous media

2020 ◽  
Vol 11 (39) ◽  
pp. 10821-10834
Author(s):  
Deborah L. Beattie ◽  
Oleksandr O. Mykhaylyk ◽  
Steven P. Armes
Keyword(s):  
Binary Mixture ◽  
Size Distribution ◽  
Self Assembly ◽  
Aqueous Media ◽  
Vesicle Size ◽  
Vesicle Size Distribution

SAXS studies confirm that a judicious binary mixture of enthalpically incompatible steric stabilizer blocks enables the synthesis of relatively small, well-defined vesicles via polymerization-induced self-assembly in aqueous media.

scholarly journals Enlarged extracellular vesicles are a negative prognostic factor in patients undergoing TACE for primary or secondary liver cancer–a case series

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255983
Author(s):  
David Schöler ◽  
Mirco Castoldi ◽  
Markus S. Jördens ◽  
Max Schulze-Hagen ◽  
Christiane Kuhl ◽  
...  
Keyword(s):  
Overall Survival ◽  
Liver Cancer ◽  
Size Distribution ◽  
Prognostic Marker ◽  
Extracellular Vesicles ◽  
Cox Regression Analysis ◽  
Vesicle Size ◽  
Potential Biomarker ◽  
Vesicle Size Distribution ◽  
Hepatic Malignancies

Background Transarterial chemoembolization (TACE) has evolved as a standard treatment option in patients with intermediate stage, unresectable HCC [Barcelona Clinic Liver Cancer (BCLC) stage B] as well as in patients with liver metastases, when surgery or systemic therapy is considered not appropriate. Concentration and sizes of extracellular vesicles (EVs) recently emerged as novel diagnostic and prognostic biomarkers in patients with liver cancer, but no data on its prognostic relevance in the context of TACE exists. Here, we evaluate pre-interventional EVs as a potential biomarker in patients undergoing TACE for primary and secondary hepatic malignancies. Methods Vesicle size distribution and concentration were measured by nanoparticle tracking analysis (NTA) in patient sera before and after TACE in 38 patients. Results Extracellular vesicle size distribution measured before TACE is of prognostic significance with respect to overall survival in patients after TACE. Overall survival is significantly reduced when initial vesicle size (X50) is in the upper quartile (>145.65nm). Median overall survival in patients in the upper quartile was only 314 days, compared to 799 days in patients with vesicle size in the first to third quartile (<145.65nm; p = 0.007). Vesicle size was also shown to be a significant prognostic marker for overall survival in Cox regression analysis [HR 1.089, 95% CI: 1.021–1.162, p = 0.010]. In addition, a significant correlation was observed between initial EVs concentration/BMI (rS = 0.358, p = 0.029), X50/IL-8-concentration (rS = 0.409, p = 0.011) and X50/CRP-concentration (rS = 0.404, p = 0.016). In contrast, with regard to immediate tumor response after TACE, EVs concentration and size did not differ. Summary Sizes (but not concentrations) of EVs represent a novel prognostic marker in patients receiving TACE for primary and secondary hepatic malignancies since patients with enlarged EVs display a significantly impaired prognosis after TACE.

scholarly journals Vesicle Size Distribution as a Novel Nuclear Forensics Tool

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163516
Author(s):  
Patrick H. Donohue ◽  
Antonio Simonetti
Keyword(s):  
Size Distribution ◽  
Nuclear Forensics ◽  
Vesicle Size ◽  
Vesicle Size Distribution

Thermal fluctuations of vesicles and nonlinear curvature elasticity—implications for size-dependent renormalized bending rigidity and vesicle size distribution

Soft Matter ◽  
2016 ◽  
Vol 12 (9) ◽  
pp. 2523-2536 ◽  
Author(s):  
Fatemeh Ahmadpoor ◽  
Pradeep Sharma
Keyword(s):  
Size Distribution ◽  
Biological Membranes ◽  
Thermal Fluctuations ◽  
Bending Rigidity ◽  
Vesicle Size ◽  
Size Dependent ◽  
Curvature Elasticity ◽  
Vesicle Size Distribution

Both closed and open biological membranes noticeably undulate at physiological temperatures.

scholarly journals Formulation and in-vitro evaluation of niosomal drug delivery system for aceclofenac.

2019 ◽  
Vol 1 (3) ◽  
pp. 84-88
Author(s):  
Samreen ◽  
M. Aruna ◽  
Shaik Harun Rasheed
Keyword(s):  
Drug Delivery ◽  
Zeta Potential ◽  
Size Distribution ◽  
Drug Delivery System ◽  
Delivery System ◽  
Entrapment Efficiency ◽  
Dosage Forms ◽  
Prolonged Release ◽  
Vesicle Size ◽  
Drug Content

In the past few decades, considerable attention has been focused on the development of new drug delivery system (NDDS). The NDDS should ideally fulfill two prerequisites. Firstly, it should deliver the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it should channel the active entity to the site of action. Conventional dosage forms including prolonged release dosage forms are unable to meet none of these. At present, no available drug delivery system behaves ideally, but sincere attempts have been made to achieve them through various novel approaches in drug delivery. The aim of present work is to develop a niosomal drug delivery system of aceclofenac. To perform drug-polymer compatibility FT-IR studies were carried out and observed that there was no interaction between the APl and excipients. 8 niosomal formulations are prepared by the thin film hydration method using the cholesterol as the phospholipid. Prepared niosomal formulations were characterized by vesicle size, shape, surface charge, entrapment efficiency, drug content and invitro drug release studies. The vesicle size, size distribution and zeta potential of the optimized formulation (F5) was found to be 65.6 nm and zeta potential was found to be -1.5mV. Size distribution curve confirms the normal size distribution of the vesicles. The % entrapment efficiency of niosomal vesicles formulations were found to be in the range of 54.18±0.59 to 92.71±0.56 and optimized formulation was found to be 92.71±0.56 and drug content of niosomes formulations (F1to F8) were determined to be in the range of 94.6 -97.8%. The pH of all topical niosomal gels were found to be in the range of 7.4±0.02 to 7.4±0.08.The best fit with higher correlation (r2> 0.99) was found with the Zero Order Release and follows Korsemeyer peppas equation for all the formulations, which means that release of Aceclofenac from the lipid bilayer vesicles were due to diffusion. The stability studies were carried out and there was no significant change found in the formulations.

The extinction time of a general birth and death process with catastrophes

1986 ◽  
Vol 23 (04) ◽  
pp. 851-858 ◽  
Author(s):  
P. J. Brockwell
Keyword(s):  
Laplace Transform ◽  
Size Distribution ◽  
Sufficient Conditions ◽  
Necessary And Sufficient Conditions ◽  
Death Process ◽  
Extinction Time ◽  
Birth And Death Process ◽  
Different Types ◽  
The Laplace Transform ◽  
Necessary And Sufficient

The Laplace transform of the extinction time is determined for a general birth and death process with arbitrary catastrophe rate and catastrophe size distribution. It is assumed only that the birth rates satisfyλ0= 0,λj&gt; 0 for eachj&gt; 0, and. Necessary and sufficient conditions for certain extinction of the population are derived. The results are applied to the linear birth and death process (λj=jλ, µj=jμ) with catastrophes of several different types.

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