Thermal fluctuations of vesicles and nonlinear curvature elasticity—implications for size-dependent renormalized bending rigidity and vesicle size distribution

Soft Matter ◽  
2016 ◽  
Vol 12 (9) ◽  
pp. 2523-2536 ◽  
Author(s):  
Fatemeh Ahmadpoor ◽  
Pradeep Sharma
Keyword(s):  
Size Distribution ◽  
Biological Membranes ◽  
Thermal Fluctuations ◽  
Bending Rigidity ◽  
Vesicle Size ◽  
Size Dependent ◽  
Curvature Elasticity ◽  
Vesicle Size Distribution

Both closed and open biological membranes noticeably undulate at physiological temperatures.

scholarly journals Enthalpic incompatibility between two steric stabilizer blocks provides control over the vesicle size distribution during polymerization-induced self-assembly in aqueous media

2020 ◽  
Vol 11 (39) ◽  
pp. 10821-10834
Author(s):  
Deborah L. Beattie ◽  
Oleksandr O. Mykhaylyk ◽  
Steven P. Armes
Keyword(s):  
Binary Mixture ◽  
Size Distribution ◽  
Self Assembly ◽  
Aqueous Media ◽  
Vesicle Size ◽  
Vesicle Size Distribution

SAXS studies confirm that a judicious binary mixture of enthalpically incompatible steric stabilizer blocks enables the synthesis of relatively small, well-defined vesicles via polymerization-induced self-assembly in aqueous media.

scholarly journals Enlarged extracellular vesicles are a negative prognostic factor in patients undergoing TACE for primary or secondary liver cancer–a case series

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255983
Author(s):  
David Schöler ◽  
Mirco Castoldi ◽  
Markus S. Jördens ◽  
Max Schulze-Hagen ◽  
Christiane Kuhl ◽  
...  
Keyword(s):  
Overall Survival ◽  
Liver Cancer ◽  
Size Distribution ◽  
Prognostic Marker ◽  
Extracellular Vesicles ◽  
Cox Regression Analysis ◽  
Vesicle Size ◽  
Potential Biomarker ◽  
Vesicle Size Distribution ◽  
Hepatic Malignancies

Background Transarterial chemoembolization (TACE) has evolved as a standard treatment option in patients with intermediate stage, unresectable HCC [Barcelona Clinic Liver Cancer (BCLC) stage B] as well as in patients with liver metastases, when surgery or systemic therapy is considered not appropriate. Concentration and sizes of extracellular vesicles (EVs) recently emerged as novel diagnostic and prognostic biomarkers in patients with liver cancer, but no data on its prognostic relevance in the context of TACE exists. Here, we evaluate pre-interventional EVs as a potential biomarker in patients undergoing TACE for primary and secondary hepatic malignancies. Methods Vesicle size distribution and concentration were measured by nanoparticle tracking analysis (NTA) in patient sera before and after TACE in 38 patients. Results Extracellular vesicle size distribution measured before TACE is of prognostic significance with respect to overall survival in patients after TACE. Overall survival is significantly reduced when initial vesicle size (X50) is in the upper quartile (>145.65nm). Median overall survival in patients in the upper quartile was only 314 days, compared to 799 days in patients with vesicle size in the first to third quartile (<145.65nm; p = 0.007). Vesicle size was also shown to be a significant prognostic marker for overall survival in Cox regression analysis [HR 1.089, 95% CI: 1.021–1.162, p = 0.010]. In addition, a significant correlation was observed between initial EVs concentration/BMI (rS = 0.358, p = 0.029), X50/IL-8-concentration (rS = 0.409, p = 0.011) and X50/CRP-concentration (rS = 0.404, p = 0.016). In contrast, with regard to immediate tumor response after TACE, EVs concentration and size did not differ. Summary Sizes (but not concentrations) of EVs represent a novel prognostic marker in patients receiving TACE for primary and secondary hepatic malignancies since patients with enlarged EVs display a significantly impaired prognosis after TACE.

scholarly journals Vesicle Size Distribution as a Novel Nuclear Forensics Tool

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163516
Author(s):  
Patrick H. Donohue ◽  
Antonio Simonetti
Keyword(s):  
Size Distribution ◽  
Nuclear Forensics ◽  
Vesicle Size ◽  
Vesicle Size Distribution

Influence of vesicle size distribution on level and selectivity of accumulation of liposomal photosensitizer Tiosens in tumor

2007 ◽  
Author(s):  
Gennady A. Meerovich ◽  
Igor G. Meerovich ◽  
Daria G. Gurevich ◽  
Sergey I. Vorobyov ◽  
Vyacheslav G. Pevgov ◽  
...  
Keyword(s):  
Size Distribution ◽  
Vesicle Size ◽  
Vesicle Size Distribution

A Cross-Method Comparison of Sub-10 nm Nanoparticle Size Distribution

2019 ◽  
Author(s):  
Ye Yang ◽  
Suiyang Liao ◽  
Zhi Luo ◽  
Runzhang Qi ◽  
Niamh Mac Fhionnlaoich ◽  
...  
Keyword(s):  
Size Distribution ◽  
Analytical Ultracentrifugation ◽  
Statistical Significance ◽  
Method Comparison ◽  
Size Determination ◽  
Size Dependent ◽  
X Ray Scattering ◽  
Transmission Electron ◽  
Gold Nps ◽  
Reliable Representation

Accurate nanoparticle (NP) size determination is essential across research domains, with many functions in nanoscience and biomedical research being size-dependent. Although transmission electron microscopy (TEM) is capable of resolving a single NP down to the sub-nm scale, the reliable representation of entire populations is plagued by challenges in providing statistical significance, predominantly due to limited sample counts, suboptimal preparation procedures and operator bias during image acquisition and analysis. Meanwhile alternative techniques exist, but reliable implementation requires a detailed understanding of appendant limitations. Herein, conventional TEM is compared to the size determination of sub-10 nm gold NPs in solution by small-angle X-ray scattering and analytical ultracentrifugation. Form-free Monte Carlo fitting of scattering profiles offers access to a direct representation of the core size distribution while ultracentrifugation sedimentation velocity analysis provides information of the hydrodynamic size distribution. We report a comparison of these three methods in determining the size of quasi-monodisperse, polydisperse and bimodal gold nanoparticles of 2 – 7 nm and discuss advantages and limitations of each technique.

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