scholarly journals Enthalpic incompatibility between two steric stabilizer blocks provides control over the vesicle size distribution during polymerization-induced self-assembly in aqueous media

2020 ◽  
Vol 11 (39) ◽  
pp. 10821-10834
Author(s):  
Deborah L. Beattie ◽  
Oleksandr O. Mykhaylyk ◽  
Steven P. Armes
Keyword(s):  
Binary Mixture ◽  
Size Distribution ◽  
Self Assembly ◽  
Aqueous Media ◽  
Vesicle Size ◽  
Vesicle Size Distribution

SAXS studies confirm that a judicious binary mixture of enthalpically incompatible steric stabilizer blocks enables the synthesis of relatively small, well-defined vesicles via polymerization-induced self-assembly in aqueous media.

Copolymer Nanoparticles Prepared by Self-Assembly of Poly(ethylene glycol) and Poly-γ-Glutamic Acid and its Characteristics

2013 ◽  
Vol 662 ◽  
pp. 136-139
Author(s):  
Ge Yang ◽  
Ke Shuai Lu ◽  
Xue Yan Su
Keyword(s):  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Size Distribution ◽  
Self Assembly ◽  
Aqueous Media ◽  
Poly Ethylene Glycol ◽  
Polyelectrolyte Complexes ◽  
Self Assembling ◽  
Transmission Electron ◽  
Poly Ethylene

The paper describes the preparation and characterization of novel biodegradable nanoparticles based on self-assembly of poly-gamma-glutamic acid (γ-PGA) and poly(ethylene glycol) (PEG). The nanosystems were stable in aqueous media at low pH conditions. Solubility of the systems was determined by turbidity measurements. The particle size and the size distribution of the polyelectrolyte complexes were identified by dynamic lightscattering and transmission electron microscopy.It was found that the size and size distribution of the nanosystems depends on the concentrations of γ-PGA and PEG solutions and their ratio as well as on the pH of the mixture and the order of addition. The diameter of individual particles was in the range of 30–270 nm. measured by TEM, and the average hydrodynamic diameters were between 130 and 300 nm. These biodegradable, self-assembling stable nanocomplexes might be useful for several biomedical applications.

scholarly journals Enlarged extracellular vesicles are a negative prognostic factor in patients undergoing TACE for primary or secondary liver cancer–a case series

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255983
Author(s):  
David Schöler ◽  
Mirco Castoldi ◽  
Markus S. Jördens ◽  
Max Schulze-Hagen ◽  
Christiane Kuhl ◽  
...  
Keyword(s):  
Overall Survival ◽  
Liver Cancer ◽  
Size Distribution ◽  
Prognostic Marker ◽  
Extracellular Vesicles ◽  
Cox Regression Analysis ◽  
Vesicle Size ◽  
Potential Biomarker ◽  
Vesicle Size Distribution ◽  
Hepatic Malignancies

Background Transarterial chemoembolization (TACE) has evolved as a standard treatment option in patients with intermediate stage, unresectable HCC [Barcelona Clinic Liver Cancer (BCLC) stage B] as well as in patients with liver metastases, when surgery or systemic therapy is considered not appropriate. Concentration and sizes of extracellular vesicles (EVs) recently emerged as novel diagnostic and prognostic biomarkers in patients with liver cancer, but no data on its prognostic relevance in the context of TACE exists. Here, we evaluate pre-interventional EVs as a potential biomarker in patients undergoing TACE for primary and secondary hepatic malignancies. Methods Vesicle size distribution and concentration were measured by nanoparticle tracking analysis (NTA) in patient sera before and after TACE in 38 patients. Results Extracellular vesicle size distribution measured before TACE is of prognostic significance with respect to overall survival in patients after TACE. Overall survival is significantly reduced when initial vesicle size (X50) is in the upper quartile (>145.65nm). Median overall survival in patients in the upper quartile was only 314 days, compared to 799 days in patients with vesicle size in the first to third quartile (<145.65nm; p = 0.007). Vesicle size was also shown to be a significant prognostic marker for overall survival in Cox regression analysis [HR 1.089, 95% CI: 1.021–1.162, p = 0.010]. In addition, a significant correlation was observed between initial EVs concentration/BMI (rS = 0.358, p = 0.029), X50/IL-8-concentration (rS = 0.409, p = 0.011) and X50/CRP-concentration (rS = 0.404, p = 0.016). In contrast, with regard to immediate tumor response after TACE, EVs concentration and size did not differ. Summary Sizes (but not concentrations) of EVs represent a novel prognostic marker in patients receiving TACE for primary and secondary hepatic malignancies since patients with enlarged EVs display a significantly impaired prognosis after TACE.

scholarly journals Vesicle Size Distribution as a Novel Nuclear Forensics Tool

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163516
Author(s):  
Patrick H. Donohue ◽  
Antonio Simonetti
Keyword(s):  
Size Distribution ◽  
Nuclear Forensics ◽  
Vesicle Size ◽  
Vesicle Size Distribution

Influence of vesicle size distribution on level and selectivity of accumulation of liposomal photosensitizer Tiosens in tumor

2007 ◽  
Author(s):  
Gennady A. Meerovich ◽  
Igor G. Meerovich ◽  
Daria G. Gurevich ◽  
Sergey I. Vorobyov ◽  
Vyacheslav G. Pevgov ◽  
...  
Keyword(s):  
Size Distribution ◽  
Vesicle Size ◽  
Vesicle Size Distribution

Thermal fluctuations of vesicles and nonlinear curvature elasticity—implications for size-dependent renormalized bending rigidity and vesicle size distribution

Soft Matter ◽  
2016 ◽  
Vol 12 (9) ◽  
pp. 2523-2536 ◽  
Author(s):  
Fatemeh Ahmadpoor ◽  
Pradeep Sharma
Keyword(s):  
Size Distribution ◽  
Biological Membranes ◽  
Thermal Fluctuations ◽  
Bending Rigidity ◽  
Vesicle Size ◽  
Size Dependent ◽  
Curvature Elasticity ◽  
Vesicle Size Distribution

Both closed and open biological membranes noticeably undulate at physiological temperatures.

scholarly journals Photoacoustics for listening to Metal Nanoparticles Super-Aggregates

2021 ◽  
Author(s):  
Roberto Li Voti ◽  
Grigore Leahu ◽  
Concita Sibilia ◽  
Roberto Matassa ◽  
Giuseppe Familiari ◽  
...  
Keyword(s):  
Metal Nanoparticles ◽  
Size Distribution ◽  
Packing Density ◽  
Self Assembly ◽  
Détection Signal ◽  
Photoacoustic Detection ◽  
New Strategy ◽  
Aggregate Packing ◽  
Detection Signal

Photoacoustic detection signal has been used to build a new strategy to determine the mesoscale self-assembly of metal nanoparticles in terms of size distribution and aggregate packing density (metal nanoparticles...

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