In vivo photoacoustic imaging with multiple selective targeting using bioconjugated gold nanorods

Author(s):  
Chen-Wei Wei ◽  
Chao-Kang Liao ◽  
Ying-Yi Chen ◽  
Churng-Ren Chris Wang ◽  
Ann-Ann Ding ◽  
...  
2019 ◽  
Vol 12 (03) ◽  
pp. 1941004
Author(s):  
Dan Wu ◽  
Xinxin Zhang ◽  
Jian Rong ◽  
Huabei Jiang

In this study, we developed a novel photoacoustic imaging technique based on poly (ethyleneglycol)-coated (PEGylated) gold nanorods (PEG-GNRs) (as the contrast agent) combined with traditional Chinese medicine (TCM) acupuncture (as the auxiliary method) for quantitatively monitoring contrast enhancement in the vasculature of a mouse brain in vivo. This study takes advantage of the strong near-infrared absorption (peak at [Formula: see text][Formula: see text]nm) of GNRs and the ability to adjust the hemodynamics of acupuncture. Experimental results show that photoacoustic tomography (PAT) successfully reveals the optical absorption variation of the vasculature of the mouse brain in response to intravenous administration of GNRs and acupuncture at the Zusanli acupoint (ST36) both individually and combined. The quantitative measurement of contrast enhancement indicates that the composite contrast agents (integration of acupuncture and GNRs) would greatly enhance the photoacoustic imaging contrast. The quantitative results also have the potential to estimate the local concentration of GNRs and even the real-time effects of acupuncture.


2008 ◽  
Author(s):  
Pai-Chi Li ◽  
Dar-Bin Shieh ◽  
Churng-Ren Wang ◽  
Chen-Wei Wei ◽  
Chao-Kang Liao ◽  
...  

2008 ◽  
Vol 16 (23) ◽  
pp. 18605 ◽  
Author(s):  
Pai-Chi Li ◽  
Churng-Ren Chris Wang ◽  
Dar-Bin Shieh ◽  
Chen-Wei Wei ◽  
Chao-Kang Liao ◽  
...  

Small ◽  
2020 ◽  
Vol 16 (37) ◽  
pp. 2002748 ◽  
Author(s):  
Kai Cai ◽  
Weiyun Zhang ◽  
Mohamed F. Foda ◽  
Xuyu Li ◽  
Jin Zhang ◽  
...  

Nanoscale ◽  
2017 ◽  
Vol 9 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Fei Gao ◽  
Linyi Bai ◽  
Siyu Liu ◽  
Ruochong Zhang ◽  
Jingtao Zhang ◽  
...  

RSC Advances ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 4561-4567 ◽  
Author(s):  
Yiping Wang ◽  
Yiduo Wu ◽  
Qiang Wen ◽  
Pengwei Li ◽  
Ying Wang ◽  
...  

PEGylated gold nanorods with broad absorption band and their enhanced photoacoustic performance.


Nanoscale ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 10511-10520 ◽  
Author(s):  
Yash Mantri ◽  
Barak Davidi ◽  
Jeanne E. Lemaster ◽  
Ali Hariri ◽  
Jesse V. Jokerst

Iodide-doping of silver coated gold nanorods increases sensitivity to RONS.


2019 ◽  
Vol 16 (2) ◽  
pp. 025603 ◽  
Author(s):  
Robin K Hartman ◽  
Kristina A Hallam ◽  
Eleanor M Donnelly ◽  
Stanislav Y Emelianov

2021 ◽  
Author(s):  
Bo Sun ◽  
Xu Zhen ◽  
Xiqun Jiang

This review mainly introduced the MSNs-based nanoprobes for in vivo bioimaging applications including fluorescence imaging and photoacoustic imaging.


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