scholarly journals Iodide-doped precious metal nanoparticles: measuring oxidative stress in vivo via photoacoustic imaging

Nanoscale ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 10511-10520 ◽  
Author(s):  
Yash Mantri ◽  
Barak Davidi ◽  
Jeanne E. Lemaster ◽  
Ali Hariri ◽  
Jesse V. Jokerst
Keyword(s):  
Oxidative Stress ◽  
Metal Nanoparticles ◽  
Gold Nanorods ◽  
Precious Metal ◽  
Photoacoustic Imaging

Iodide-doping of silver coated gold nanorods increases sensitivity to RONS.

In vivo photoacoustic imaging with multiple selective targeting using bioconjugated gold nanorods

2008 ◽  
Author(s):  
Chen-Wei Wei ◽  
Chao-Kang Liao ◽  
Ying-Yi Chen ◽  
Churng-Ren Chris Wang ◽  
Ann-Ann Ding ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Selective Targeting

scholarly journals Photoacoustic molecular imaging using combined acupuncture and gold nanorods as a composite contrast agent

2019 ◽  
Vol 12 (03) ◽  
pp. 1941004
Author(s):  
Dan Wu ◽  
Xinxin Zhang ◽  
Jian Rong ◽  
Huabei Jiang
Keyword(s):  
Contrast Agent ◽  
Contrast Enhancement ◽  
Mouse Brain ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Local Concentration ◽  
Quantitative Results ◽  
Zusanli Acupoint

In this study, we developed a novel photoacoustic imaging technique based on poly (ethyleneglycol)-coated (PEGylated) gold nanorods (PEG-GNRs) (as the contrast agent) combined with traditional Chinese medicine (TCM) acupuncture (as the auxiliary method) for quantitatively monitoring contrast enhancement in the vasculature of a mouse brain in vivo. This study takes advantage of the strong near-infrared absorption (peak at [Formula: see text][Formula: see text]nm) of GNRs and the ability to adjust the hemodynamics of acupuncture. Experimental results show that photoacoustic tomography (PAT) successfully reveals the optical absorption variation of the vasculature of the mouse brain in response to intravenous administration of GNRs and acupuncture at the Zusanli acupoint (ST36) both individually and combined. The quantitative measurement of contrast enhancement indicates that the composite contrast agents (integration of acupuncture and GNRs) would greatly enhance the photoacoustic imaging contrast. The quantitative results also have the potential to estimate the local concentration of GNRs and even the real-time effects of acupuncture.

Miniature Hollow Gold Nanorods with Enhanced Effect for In Vivo Photoacoustic Imaging in the NIR‐II Window

Small ◽  
2020 ◽  
Vol 16 (37) ◽  
pp. 2002748 ◽  
Author(s):  
Kai Cai ◽  
Weiyun Zhang ◽  
Mohamed F. Foda ◽  
Xuyu Li ◽  
Jin Zhang ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photoacoustic Imaging

Rationally encapsulated gold nanorods improving both linear and nonlinear photoacoustic imaging contrast in vivo

Nanoscale ◽  
2017 ◽  
Vol 9 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Fei Gao ◽  
Linyi Bai ◽  
Siyu Liu ◽  
Ruochong Zhang ◽  
Jingtao Zhang ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Linear And Nonlinear

scholarly journals PEGylated gold nanorods with a broad absorption band in the first near-infrared window for in vivo multifunctional photoacoustic imaging

RSC Advances ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 4561-4567 ◽  
Author(s):  
Yiping Wang ◽  
Yiduo Wu ◽  
Qiang Wen ◽  
Pengwei Li ◽  
Ying Wang ◽  
...  
Keyword(s):  
Absorption Band ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Broad Absorption ◽  
Broad Absorption Band ◽  
Infrared Window

PEGylated gold nanorods with broad absorption band and their enhanced photoacoustic performance.

scholarly journals Photoacoustic imaging of gold nanorods in the brain delivered via microbubble-assisted focused ultrasound: a tool for in vivo molecular neuroimaging

2019 ◽  
Vol 16 (2) ◽  
pp. 025603 ◽  
Author(s):  
Robin K Hartman ◽  
Kristina A Hallam ◽  
Eleanor M Donnelly ◽  
Stanislav Y Emelianov
Keyword(s):  
Gold Nanorods ◽  
Focused Ultrasound ◽  
Photoacoustic Imaging ◽  
The Brain

Glial cytotoxicity of low doses of cadmium as a model of heavy metal pollution influence on vertebrates

2020 ◽  
Vol 31 (1) ◽  
pp. 3-10
Author(s):  
V. S. Nedzvetsky ◽  
V. Ya. Gasso ◽  
A. M. Hahut ◽  
I. A. Hasso
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Oxidative Damage ◽  
Cadmium Chloride ◽  
Glioma Cells ◽  
Low Doses ◽  
Genotoxic Effects ◽  
Cadmium Ions

Cadmium is a common transition metal that entails an extremely wide range of toxic effects in humans and animals. The cytotoxicity of cadmium ions and its compounds is due to various genotoxic effects, including both DNA damage and chromosomal aberrations. Some bone diseases, kidney and digestive system diseases are determined as pathologies that are closely associated with cadmium intoxication. In addition, cadmium is included in the list of carcinogens because of its ability to initiate the development of tumors of several forms of cancer under conditions of chronic or acute intoxication. Despite many studies of the effects of cadmium in animal models and cohorts of patients, in which cadmium effects has occurred, its molecular mechanisms of action are not fully understood. The genotoxic effects of cadmium and the induction of programmed cell death have attracted the attention of researchers in the last decade. In recent years, the results obtained for in vivo and in vitro experimental models have shown extremely high cytotoxicity of sublethal concentrations of cadmium and its compounds in various tissues. One of the most studied causes of cadmium cytotoxicity is the development of oxidative stress and associated oxidative damage to macromolecules of lipids, proteins and nucleic acids. Brain cells are most sensitive to oxidative damage and can be a critical target of cadmium cytotoxicity. Thus, oxidative damage caused by cadmium can initiate genotoxicity, programmed cell death and inhibit their viability in the human and animal brains. To test our hypothesis, cadmium cytotoxicity was assessed in vivo in U251 glioma cells through viability determinants and markers of oxidative stress and apoptosis. The result of the cell viability analysis showed the dose-dependent action of cadmium chloride in glioma cells, as well as the generation of oxidative stress (p <0.05). Calculated for 48 hours of exposure, the LD50 was 3.1 μg×ml-1. The rates of apoptotic death of glioma cells also progressively increased depending on the dose of cadmium ions. A high correlation between cadmium concentration and apoptotic response (p <0.01) was found for cells exposed to 3–4 μg×ml-1 cadmium chloride. Moreover, a significant correlation was found between oxidative stress (lipid peroxidation) and induction of apoptosis. The results indicate a strong relationship between the generation of oxidative damage by macromolecules and the initiation of programmed cell death in glial cells under conditions of low doses of cadmium chloride. The presented results show that cadmium ions can induce oxidative damage in brain cells and inhibit their viability through the induction of programmed death. Such effects of cadmium intoxication can be considered as a model of the impact of heavy metal pollution on vertebrates.

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