Rationally encapsulated gold nanorods improving both linear and nonlinear photoacoustic imaging contrast in vivo

Nanoscale ◽  
2017 ◽  
Vol 9 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Fei Gao ◽  
Linyi Bai ◽  
Siyu Liu ◽  
Ruochong Zhang ◽  
Jingtao Zhang ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Linear And Nonlinear

In vivo photoacoustic imaging with multiple selective targeting using bioconjugated gold nanorods

2008 ◽  
Author(s):  
Chen-Wei Wei ◽  
Chao-Kang Liao ◽  
Ying-Yi Chen ◽  
Churng-Ren Chris Wang ◽  
Ann-Ann Ding ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Selective Targeting

scholarly journals Photoacoustic molecular imaging using combined acupuncture and gold nanorods as a composite contrast agent

2019 ◽  
Vol 12 (03) ◽  
pp. 1941004
Author(s):  
Dan Wu ◽  
Xinxin Zhang ◽  
Jian Rong ◽  
Huabei Jiang
Keyword(s):  
Contrast Agent ◽  
Contrast Enhancement ◽  
Mouse Brain ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Local Concentration ◽  
Quantitative Results ◽  
Zusanli Acupoint

In this study, we developed a novel photoacoustic imaging technique based on poly (ethyleneglycol)-coated (PEGylated) gold nanorods (PEG-GNRs) (as the contrast agent) combined with traditional Chinese medicine (TCM) acupuncture (as the auxiliary method) for quantitatively monitoring contrast enhancement in the vasculature of a mouse brain in vivo. This study takes advantage of the strong near-infrared absorption (peak at [Formula: see text][Formula: see text]nm) of GNRs and the ability to adjust the hemodynamics of acupuncture. Experimental results show that photoacoustic tomography (PAT) successfully reveals the optical absorption variation of the vasculature of the mouse brain in response to intravenous administration of GNRs and acupuncture at the Zusanli acupoint (ST36) both individually and combined. The quantitative measurement of contrast enhancement indicates that the composite contrast agents (integration of acupuncture and GNRs) would greatly enhance the photoacoustic imaging contrast. The quantitative results also have the potential to estimate the local concentration of GNRs and even the real-time effects of acupuncture.

Miniature Hollow Gold Nanorods with Enhanced Effect for In Vivo Photoacoustic Imaging in the NIR‐II Window

Small ◽  
2020 ◽  
Vol 16 (37) ◽  
pp. 2002748 ◽  
Author(s):  
Kai Cai ◽  
Weiyun Zhang ◽  
Mohamed F. Foda ◽  
Xuyu Li ◽  
Jin Zhang ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photoacoustic Imaging

scholarly journals PEGylated gold nanorods with a broad absorption band in the first near-infrared window for in vivo multifunctional photoacoustic imaging

RSC Advances ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 4561-4567 ◽  
Author(s):  
Yiping Wang ◽  
Yiduo Wu ◽  
Qiang Wen ◽  
Pengwei Li ◽  
Ying Wang ◽  
...  
Keyword(s):  
Absorption Band ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Broad Absorption ◽  
Broad Absorption Band ◽  
Infrared Window

PEGylated gold nanorods with broad absorption band and their enhanced photoacoustic performance.

scholarly journals Iodide-doped precious metal nanoparticles: measuring oxidative stress in vivo via photoacoustic imaging

Nanoscale ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 10511-10520 ◽  
Author(s):  
Yash Mantri ◽  
Barak Davidi ◽  
Jeanne E. Lemaster ◽  
Ali Hariri ◽  
Jesse V. Jokerst
Keyword(s):  
Oxidative Stress ◽  
Metal Nanoparticles ◽  
Gold Nanorods ◽  
Precious Metal ◽  
Photoacoustic Imaging

Iodide-doping of silver coated gold nanorods increases sensitivity to RONS.

scholarly journals Photoacoustic imaging of gold nanorods in the brain delivered via microbubble-assisted focused ultrasound: a tool for in vivo molecular neuroimaging

2019 ◽  
Vol 16 (2) ◽  
pp. 025603 ◽  
Author(s):  
Robin K Hartman ◽  
Kristina A Hallam ◽  
Eleanor M Donnelly ◽  
Stanislav Y Emelianov
Keyword(s):  
Gold Nanorods ◽  
Focused Ultrasound ◽  
Photoacoustic Imaging ◽  
The Brain

Development of mesoporous silica-based nanoprobes for optical bioimaging applications

2021 ◽  
Author(s):  
Bo Sun ◽  
Xu Zhen ◽  
Xiqun Jiang
Keyword(s):  
Mesoporous Silica ◽  
Fluorescence Imaging ◽  
Photoacoustic Imaging

This review mainly introduced the MSNs-based nanoprobes for in vivo bioimaging applications including fluorescence imaging and photoacoustic imaging.

scholarly journals In Vitro and In Vivo Multispectral Photoacoustic Imaging for the Evaluation of Chromophore Concentration

Sensors ◽  
2021 ◽  
Vol 21 (10) ◽  
pp. 3366
Author(s):  
Aneline Dolet ◽  
Rita Ammanouil ◽  
Virginie Petrilli ◽  
Cédric Richard ◽  
Piero Tortoli ◽  
...  
Keyword(s):  
Remote Sensing ◽  
Photoacoustic Imaging ◽  
Hyperspectral Remote Sensing ◽  
Reference Spectrum ◽  
In Vivo Experiments ◽  
Mouse Tumors ◽  
Chromophore Concentration ◽  
Saturation Rate

Multispectral photoacoustic imaging is a powerful noninvasive medical imaging technique that provides access to functional information. In this study, a set of methods is proposed and validated, with experimental multispectral photoacoustic images used to estimate the concentration of chromophores. The unmixing techniques used in this paper consist of two steps: (1) automatic extraction of the reference spectrum of each pure chromophore; and (2) abundance calculation of each pure chromophore from the estimated reference spectra. The compared strategies bring positivity and sum-to-one constraints, from the hyperspectral remote sensing field to multispectral photoacoustic, to evaluate chromophore concentration. Particularly, the study extracts the endmembers and compares the algorithms from the hyperspectral remote sensing domain and a dedicated algorithm for segmentation of multispectral photoacoustic data to this end. First, these strategies are tested with dilution and mixing of chromophores on colored 4% agar phantom data. Then, some preliminary in vivo experiments are performed. These consist of estimations of the oxygen saturation rate (sO2) in mouse tumors. This article proposes then a proof-of-concept of the interest to bring hyperspectral remote sensing algorithms to multispectral photoacoustic imaging for the estimation of chromophore concentration.

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